Environmental Illness

Data highlight potential for new diagnostics and therapeutics targeting red meat allergy SOUTH SAN FRANCISCO, Calif., Feb. 10, 2025 /PRNewswire/ -- IgGenix, Inc., a clinical-stage biotechnology company pioneering innovative treatments for immune-mediated diseases, today announced the upcoming presentation of new data at the 2025 American Academy of Allergy, Asthma & Immunology (AAAAI) / World Allergy Organization (WAO) Joint Congress, to be held February 28 - March 3, 2025, in San Diego, California. The data showcase the discovery of alpha-gal-specific monoclonal antibodies (mAbs) from red meat-allergic individuals, marking an advancement in the understanding of Alpha-gal Syndrome (AGS), also known as red meat allergy. "Alpha-gal Syndrome is a complex condition that disrupts daily life for those affected, and understanding its mechanisms is key to addressing the impact," said Jessica Grossman, MD, CEO of IgGenix. "This discovery is a meaningful step forward, offering new insights into AGS and broader immune responses that could lead to breakthrough treatments in this and other immune-mediated conditions." Little is known about the properties of mAbs underlying AGS in humans due to the technical difficulty of isolating rare single B cells that produce alpha-gal-specific mAbs. Using its proprietary SEQ SIFTER™ platform, IgGenix discovered more than 60 mAbs from several red meat-allergic individuals. These antibodies exhibited a narrow binding affinity range despite diverse variable domain gene usage and antibody affinity maturation, suggesting molecular mechanisms that distinguish AGS from canonical food protein allergen hypersensitivity. Clonal families of similar antibodies exhibited persistence over time, suggesting mechanisms underpinning immunological memory in AGS. Presentation Details: Abstract Title: Alpha-gal Specific Monoclonal Antibodies Discovered from Red Meat Allergic Individuals Poster Number: 843 Session Title: Novel Genes and Biomarkers of Allergic Disease Session Type: Poster Session Session Date/Time: Sunday, March 2, 9:45 am - 10:45 am About IgGenix IgGenix is a privately held antibody discovery and development company taking a revolutionary approach to directly address allergies and atopic diseases. Through our proprietary SEQ SIFTER™ discovery platform, developed from foundational research of co-founders Stephen Quake, Kari Nadeau, and Derek Croote of Stanford University, we isolate and re-engineer fully human, high-affinity, allergen-specific antibodies designed to block and prevent the allergic cascade. By targeting common immunodominant allergens and their most important epitopes across the patient population, we intend to treat allergic pediatric and adult patients alike across food and environmental allergies. This novel approach may prevent life-threatening allergic reactions, saving lives and reducing the constant fear that affects millions of people living with severe allergies. SOURCE IgGenix WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

LOS ANGELES, Oct. 30, 2024 /PRNewswire/ -- Dr. Scott McMahon of Whole World Health Care is happy to announce the launch of the MEDICINE AND MIRACLES podcast during the month of October, recognized as Health Literacy Month, an international observance where many health organizations work together to promote health literacy awareness. The podcast, hosted by Dr. McMahon, will integrate medical expertise with spiritual healing, offering a unique look at health and recovery through a faith-based perspective. Each episode will delve into inspiring stories, healing practices, and transformative journeys. Dr. McMahon hopes to create a supportive community that embraces positivity, fosters personal growth and give listeners a sense of hope. Continue Reading MEDICINE AND MIRACLES, hosted by Dr. Scott McMahon, will integrate medical expertise with spiritual healing, offering a unique look at health and recovery through a faith-based perspective. Many of the episodes will address the mystery of Chronic Inflammatory Response Syndrome (CIRS), triggered by mold illness and exposure, which debilitates the health of millions each year. Dr. McMahon is a pediatrician and medical expert, specializing in the field of CIRS in kids and adults. He's considered one of the top CIRS pediatric expert across the country, and one of the top CIRS specialists in the world. "Chronic Inflammatory Response Syndrome (CIRS) is still a mystery to the medical community. Each year, millions of people are misdiagnosed and suffer from a multitude of symptoms, caused by mold illness and exposure," said Dr. McMahon. "I hope the MEDICINE AND MIRACLES podcast will offer listeners some accessible, bite-sized information about the condition; spark some 'aha moments' about their own health; and lead them down a road of healing and recovery." Dr. McMahon added he wants to give listeners, who may be dealing with a chronic health issue, a sense of hope because "miracles still happen every single day!" he said. CIRS is a multisystem illness affecting many areas of the body. Every year, mold exposure affects the health of millions of Americans – kids, teens and adults -- with symptoms that include chronic fatigue and pain, watery eyes, headaches, respiratory issues, brain fog, irritability and sleep problems – just to name a few. Oftentimes, these symptoms can lead to patients being misdiagnosed for other disorders like lupus, rheumatoid arthritis, Sjogren's syndrome, chronic fatigue syndrome, IBS, fibromyalgia, multiple sclerosis (MS), chronic regional pain syndrome and many other illnesses. For more information about CIRS, visit CIRSx.com. Throughout the year, Dr. McMahon speaks on mold-related health concerns and CIRS at many statewide, national and international medical conventions and meetings. Throughout his career, he's evaluated approximately 2,000 patients for CIRS from 48 states and 21 countries. And when he's not working with patients, he's also a medical expert in court cases nationwide for mold-related lawsuits. MEDICINE AND MIRACLES can be found on digital platforms, including Spotify, iHeart Radio and Amazon Podcast. JUST DROPPED!! THE MEDICINE AND MIRACLE PODCAST Now on Spotify: Now on iHeartRadio: Now on Amazon Podcasts: ABOUT SCOTT MCMAHON | pediatrician, medical expert and author Dr. Scott McMahon is a pediatrician, author and medical expert, specializing in the field of Chronic Inflammatory Response Syndrome (CIRS), in kids and adults. He is the author of several books, including "The Art and Science of CIRS Medicine," co-written with Dr. Ritchie Shoemaker and Dr. Andrew Heyman, which addresses mold illness. He's also authored or co-authored more than a dozen scientific papers on mold illness and contributed to a couple of medical textbooks. He's one of the leading voices on advancing the science to treat, educate and serve those suffering with CIRS. And when he's not working with patients, he serves as a medical expert in courts across the country, participating in "mold litigation" for plaintiff and the defense cases. He's recognized as a qualified CIRS medical expert for the judicial system in ten states in the United States as well as Quebec, Canada. He's been involved in more than 100 disability, workers compensation and personal injury cases, testifying in ten states as well as Canada, England and soon in the Bahamas. He received his bachelor's degree in chemistry from Creighton University, located in Omaha, Nebraska, in 1985 and completed his medical degree at Creighton University School of Medicine in 1989. Dr. McMahon went on to finish a prestigious pediatric residency at Duke University Medical Center in Durham, North Carolina in 1992. He has maintained board certification since 1992 and practiced pediatrics in Roswell, New Mexico, for more than 30 years. Four years ago, he retired from active pediatric practice; but continues to serve as a pediatric hospitalist. Dr. McMahon currently resides in Roswell, New Mexico with his wife, Mary, and their eight children. He's also an ordained minister through Joan Hunter Ministries. For more about Dr. McMahon and the podcast, visit MedicineAndMiracles.co. SOURCE Dr. Scott McMahon of Whole World Health Care WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

SOUTH SAN FRANCISCO, Calif., Sept. 2, 2024 /PRNewswire/ -- IgGenix, Inc., a preclinical antibody discovery and development company taking a revolutionary approach to address IgE-mediated diseases, presented exciting data on the company's lead candidate, IGNX001, an IgG4 monoclonal antibody-based therapeutic for peanut allergy. These data were presented during the 2024 Annual Conference of the Australasian Society of Clinical Immunology and Allergy (ASCIA), taking place in Adelaide, Australia from September 3-6, 2024. Highlights from ASCIA Michael O'Sullivan, MBBS, FRACP, FRCPA, lead investigator, presented information on IgGenix's Phase 1 human clinical trial in peanut allergy "ACCELERATE Peanut." This study, which is active and screening, will evaluate the safety and tolerability of IGNX001, a therapeutic candidate which aims to offer the potential of rapid protection for peanut allergic patients. Derek Croote PhD, chief technology officer and co-founder of IgGenix, presented preclinical data on IGNX001 demonstrating robust protection against peanut-mediated mast cell activation, as well as against anaphylaxis in a murine model of peanut allergy. The complete preclinical findings were recently published in The Journal of Allergy and Clinical Immunology. "IGNX001 marks a potentially major step forward in treating peanut allergies," said Michael O'Sullivan, MBBS, FRACP, FRCPA, Consultant Clinical Immunologist at Fiona Stanley Hospital and Perth Children's Hospital, and Clinical Senior Lecturer at the University of Western Australia. "By using cutting edge research to re-engineer harmful IgE antibodies to IgG4 blocking antibodies that bind to allergens without causing reactions, this approach offers the potential for a faster, more effective alternative to current therapies. It has the potential to help change peanut allergy management, reducing severe reaction risks and improving quality of life for millions worldwide." Oral Presentation Title: Accelerating Towards Treatment Options for Adolescents and Adults With Peanut Allergy: Phase 1 Trial of Peanut-Specific Igg4 Antibody Therapeutic (IGNX001) Presenter: Michael O'Sullivan, MBBS, FRACP, FRCPA Poster Presentation Title: Preclinical Activity and GLP Safety Toxicology Data Ahead of Phase 1 Initiation of IGNX001 in Peanut Allergy Presenter: Derek Croote, PhD The abstracts can be accessed here. About IgGenix IgGenix is a privately held antibody discovery and development company taking a revolutionary approach to directly address allergies and atopic diseases. Through our proprietary SEQ SIFTER™ discovery platform, developed from foundational research of co-founders Stephen Quake, Kari Nadeau, and Derek Croote of Stanford University, we isolate and re-engineer fully human, high-affinity, allergen-specific antibodies designed to block and prevent the allergic cascade. By targeting common immunodominant allergens and their most important epitopes across the patient population, we intend to treat allergic pediatric and adult patients alike across food and environmental allergies. This novel approach may prevent life-threatening allergic reactions, saving lives and reducing the constant fear that affects millions of people living with severe allergies. SOURCE IgGenix