Last update 21 Mar 2024
Hyaline Membrane Diseases
Last update 21 Mar 2024
Basic Info
Synonyms Disease, Hyaline Membrane, Diseases, Hyaline Membrane, HMD - Hyaline membrane disease + [23] |
Introduction A respiratory distress syndrome in newborn infants, usually premature infants with insufficient PULMONARY SURFACTANTS. The disease is characterized by the formation of a HYALINE-like membrane lining the terminal respiratory airspaces (PULMONARY ALVEOLI) and subsequent collapse of the lung (PULMONARY ATELECTASIS). |
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100 Clinical Results associated with Hyaline Membrane Diseases
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100 Translational Medicine associated with Hyaline Membrane Diseases
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14 Feb 2024Pediatric pulmonology
The impact of undergoing elective pediatric lung resection during respiratory syncytial virus peak season on patient outcomes: A nationwide retrospective analysis.
Article
Author: Pooja S Salvi ; Joseph K Canner ; Barbara Coons ; Robert A Cowles ; Abigail J Engwall-Gill ; Shaun M Kunisaki ; Annalise B Penikis ; Eric Schneider ; Shelby R Sferra ; Daniel G Solomon
OBJECTIVES:
Observational data to support delaying elective pediatric thoracic surgery during peak respiratory viral illness season is lacking. This study evaluated whether lung surgery during peak viral season is associated with differences in postoperative outcomes and resource utilization.
METHODS:
A retrospective observational cohort study was performed using the Pediatric Health Information System (PHIS). Patients with a congenital lung malformation (CLM) who underwent elective lung resection between 1 January 2016 and 29 February 2020 were included. Respiratory syncytial virus (RSV) incidence was used as a proxy for respiratory viral illness circulation. Monthly hospital-specific RSV incidence was calculated from PHIS data, and peak RSV season was defined by Centers for Disease Control data. Multivariable regression models were built to identify predictors of postoperative mechanical ventilation, which was the main outcome measure, as well as secondary outcomes including 30-day readmission after lung resection, postoperative length of stay (LOS) and hospital billing charges.
RESULTS:
Of 1542 CLM patients identified, 344 (22.3%) underwent lung resection during peak RSV season. 38% fewer operations were performed per month during peak RSV season than during off-peak months (p < .001). Children who underwent surgery during peak RSV season did not differ from the off-peak group in terms of age at operation, race, or comorbid conditions (i.e., congenital heart disease, newborn respiratory distress, and preoperative pneumonia). There was no association between hospital-specific RSV incidence at the time of surgery and postoperative mechanical ventilation, postoperative LOS, 30-day readmission rate or hospital billing charges.
DISCUSSION:
Performing elective lung surgery in children with CLMs during peak viral season is not associated with adverse surgical outcomes or increased utilization of healthcare resources.
01 Feb 2024Food science & nutrition
The ailments that stem from cheese and relevant precautions taken in the Ottoman Empire from the 19th century to the 20th century.
Article
Author: Ayşe Erkmen ; Nevim Tüzün ; Osman Erkmen
The increase in cheese production, sale, and consumption due to the settled lives of societies has led to an increase in cheese-related diseases. It has become essential to better understand cheese-borne diseases and to develop control measures. In this study, cheese-related diseases and precautions taken in the Ottoman Empire from the 19th to the 20th centuries were investigated in Ottoman archival sources. Of these documents, cheese spoilage was detected in 12 and cheese-related disease in 9. Cheeses that caused diseases or disorders in the relevant period were called spoiled cheese. One document states that a person died of a cheese-borne illness. Cheese poisoning occurs mainly from unsalted, fresh cheeses. It has been determined that tin-free copper pots were used in cheese production and sales and covered with herbs such as hemlock during maturation. In the relevant period, microbiological and chemical analyses of cheeses in terms of health were carried out in food control laboratories. Since the mercury chloride solution is used to disinfect animal udders, it has been stated that it contaminates the milk used in cheese production. Authorities have requested a boric acid solution (5% boric acid in hot water) instead of this solution for udder disinfection. In the Ottoman Empire, it was requested to take necessary sanitation and hygiene measures to prevent spoilage and cheese-related diseases in the production areas or sales places of cheese. Clean and tinned containers should be used in cheese production, storage, and sale, and poisonous herbs should not be used during cheese ripening. It was also essential to analyze them in laboratories at internal and external customs. Knowing the precautions taken in the past to prevent the deterioration of food or the occurrence of diseases has led to modern food safety practices being applied today.
30 Jan 2024Heliyon
Neonatal jaundice and associated factors in public hospitals of southern Ethiopia: A multi-center cross-sectional study.
Article
Author: Agegnehu Bante ; Muluken Ahmed ; Nega Degefa ; Shitaye Shibiru ; Manaye Yihune
Background:
Neonatal jaundice is one of the most prevalent problems, affecting over a million newborns globally every year. It increases the likelihood of hospitalization, lifetime disability, and death, particularly in low and middle-income countries. Despite its impact and diverse risk factors, neonatal jaundice remains underappreciated in developing nations such as Ethiopia. As a result, this study aimed to determine the magnitude and associated factors of jaundice in newborns admitted to public hospitals in south Ethiopia.
Methods:
A facility-based cross-sectional study was conducted among 417 newborns from October 1, 2020, to April 30, 2021. The data was collected using pretested interviewer-administered questionnaire and checklist. Jaundice and its severity were assessed using the physician's diagnosis and the Kramer scale. Open data kit tools and Stata version 16.0 were used for data collection and analysis, respectively. Bivariable and multivariable analyses were used to identify factors associated with neonatal jaundice. An odds ratio with a 95 % confidence interval was used to assess the direction and strength of the association.
Results:
Out of the newborns, 24.46 % [95 % CI: 20.42-28.88] encountered neonatal jaundice. Being male [AOR: 1.81, 95 % CI: 1.06, 3.12], birth injuries [AOR: 3.01, 95 % CI: 1.27, 7.12], perinatal asphyxia [AOR: 2.10, 95 % CI: 1.18, 3.76], hyaline membrane disease [AOR: 2.16, 95 % CI: 1.16, 4.00], sepsis [AOR: 3.30, (95 % CI: 1.67, 6.54], the combined effect of low birth weight and prematurity [AOR: 1.88, 95 % CI: 1.06, 3.35], and maternal alcohol abuse during pregnancy [AOR: 2.46, 95 % CI: 1.02, 5.94] were significantly associated with neonatal jaundice.
Conclusion:
The burden of neonatal jaundice was high in the hospitals studied. Early detection and treatment of neonatal problems, counseling pregnant women to avoid consuming any level of alcohol, strict monitoring of labor and delivery, improving antenatal care utilization, and pre-discharge universal bilirubin screening of newborns are essential to reduce the incidence and complications of jaundice. The findings of this study will be used as input to initiate interventions and conduct further studies.
24 Jan 2024
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