Glutamate Monosodium Sensitivity

Last update 08 May 2025

Basic Info

Synonyms

CHINESE RESTAURANT SYNDROME, Chinese Restaurant Syndrome, Chinese restaurant syndrome

+ [24]

Introduction-

Clinical Trials associated with Glutamate Monosodium Sensitivity

TCTR20190326003

/ CompletedPhase 2IIT

The correlation of area under the curve with single time point concentration of mycophenolic acid and its metabolite in Thai kidney transplant recipients receiving enteric-coated mycophenolate sodium

Start Date15 Aug 2018

Sponsor / Collaborator-

RBR-9k66x6

/ RecruitingNot ApplicableIIT

Everolimo in combination with Tacrolimus low doses versus Mycophenolate Sodium gastro-resistant coated tablets with low doses of Tacrolimus in Liver Transplant recipients de novo”

Start Date14 Jan 2016

Sponsor / Collaborator-

100 Clinical Results associated with Glutamate Monosodium Sensitivity

100 Translational Medicine associated with Glutamate Monosodium Sensitivity

0 Patents (Medical) associated with Glutamate Monosodium Sensitivity

206

Literatures (Medical) associated with Glutamate Monosodium Sensitivity

01 Apr 2025·Physiology & Behavior

Impact of monosodium glutamate-induced obesity on learning, memory, and DNA damage: Sex-based comparative study in rats

Article

Author: Anber, Tunahan ; Tunc-Ata, Melek ; Akbudak, Ismail Hakki ; Altintas, Fatih ; Akca, Hasan ; Sayin, Dilek ; Kucukatay, Vural

Obesity is a global health crisis linked to numerous adverse outcomes including cardiovascular disease, type 2 diabetes, cancer and cognitive decline. This study investigated the sex-specific effects of monosodium glutamate (MSG)-induced obesity on learning, memory, anxiety-like behavior, oxidative stress, and genotoxicity in rats. In 32 neonatal Wistar albino rats, subcutaneous MSG injections were administered to induce obesity. Both male and female obese rats displayed significant abdominal fat accumulation, with a more pronounced increase in females. Cognitive assessments using the Morris water maze test revealed substantial impairments in learning and memory in both sexes, although no significant sex-related differences were observed. Anxiety-like behavior remained unaffected by obesity in both sexes, as indicated by behavioral tests. Oxidative stress in the hippocampus, measured by total oxidant and antioxidant levels, did not show significant alterations. However, the study found genotoxic effects in female obese rats, indicated by DNA damage, whereas male rats did not exhibit such effects. The results suggest that MSG-induced obesity negatively impacts cognitive function and causes genotoxicity, particularly in females, highlighting the potential sex-specific vulnerabilities in obesity-related pathologies. This research provides valuable insights into the cognitive and genetic consequences of obesity, with implications for understanding complex biological mechanisms across sexes.

01 Apr 2025·Clinical Implant Dentistry and Related Research

Maxillary Sinus Grafting Complications: Diagnosis, Management, Patient Outcomes, and Role of Multidisciplinary Care

Review

Author: Saibene, Alberto Maria ; Wallace, Stephen S. ; Scaini, Riccardo

ABSTRACTBackgroundMaxillary sinus grafting (MSG) is often crucial for successful dental implant placement in the atrophic maxilla. However, it carries the risk of sinonasal complications, with outcomes frequently influenced by the patient's sinonasal health and the subjective assessment of surgeons. Thorough preoperative evaluation by otolaryngologists is vital to reduce these risks.PurposeThis study emphasizes the importance of interdisciplinary collaboration in managing sinonasal complications following MSG. By highlighting the role of otolaryngologists in preoperative evaluations and proposing a systematic approach, it aims to improve surgical planning and optimize patient outcomes.DiscussionSinonasal complications after MSG can be classified into early and delayed categories, each requiring distinct management approaches. Early complications, such as infections and graft migration, demand immediate attention, while delayed issues, like implant osseointegration failure, pose longer term challenges. Accurate diagnosis is often difficult due to the overlap of symptoms with other sinus conditions, necessitating comprehensive clinical evaluations, endoscopic findings, and radiographic imaging. Collaboration between dental and otolaryngology specialists is essential, underscoring the need for a multidisciplinary strategy in managing these complications.ConclusionManaging sinonasal complications post‐MSG requires prompt diagnosis and a combination of medical and surgical interventions. Early detection and treatment, supported by a structured interdisciplinary approach, are key to improving patient outcomes. Integrating dental and otolaryngological expertise is critical to ensuring the success of MSG procedures and enhancing overall patient care.

01 Jan 2025·Oxidative Medicine and Cellular Longevity

Efficacy of Plasmalogens on Monosodium Glutamate‐Induced Neurotoxicity in Male Rats Through NF‐κB and p38 MAPK Signaling Pathways

Article

Author: Hamaad, Fatma A ; Elmageed, Ghada M Abd ; Katano, Hideki ; Ghoneum, Mamdooh H ; Abdou, Heba M

Monosodium glutamate (MSG) is the most commonly used food additive and has well‐known neurotoxic effects. The current study was carried out to assess the underlying mechanisms of the neurotoxicity of MSG on the hippocampus in male rats and examine the protective effect of plasmalogens (Pls) on nuclear factor‐B (NF‐κB) and p38 MAPK signaling pathways in the hippocampus using behavioral, biochemical, and immunohistochemical methods. Twenty‐four male Wistar albino rats were divided into four groups for control or treatment with MSG (2 g/kg body weight) and/or Pls (100 mg/kg body weight). All doses were received orally for 28 days. Results show that plasmalogens ameliorate the levels of glucose, insulin, lipids, oxidative stress markers, antioxidant enzymes, AKT, and neurochemical markers. It also reduces the level of the inflammatory markers TNF‐α, NF‐κB, and p38 mitogen‐activated protein kinase (MAPK). Histological and immunohistochemical alterations in hippocampal tissues were found to be augmented postexposure to Pls, suggesting that Pls have a potent ameliorative effect. We conclude that Pls exert anti‐inflammatory, antioxidant, and antiapoptotic effects and counteract MSG‐induced neurotoxicity by altering the NF‐κB and p38 MAPK signaling pathways.

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