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Last update 08 May 2025

Impotence, Vasculogenic

Last update 08 May 2025

Basic Info

Synonyms

Impotence, Vasculogenic, Impotence, Venogenic, Leakage, Penile Venous

+ [22]

Introduction

Inability to achieve and maintain an erection (ERECTILE DYSFUNCTION) due to defects in the arterial blood flow to the PENIS, defect in venous occlusive function allowing blood drainage (leakage) from the erectile tissue (corpus cavernosum penis), or both.

Clinical Trials associated with Impotence, Vasculogenic

NCT02492386

/ Unknown statusPhase 2/3IIT

Safety and Feasibility of Bioabsorbable Everolimus-Eluting Stents for Patients With Internal Pudendal Artery-Related Arteriogenic Erectile Dysfunction (PERFECT-ABSORB)

In this prospective, unblinded, single-arm, single-center study, investigators would like to assess the feasibility and safety of the bioabsorbable everolimus-eluting stents in patients with erectile dysfunction and concomitant internal pudendal artery stenoses. A total of 15 bioabsorbable vascular scaffolds (BVSs) are planned to be assessed and will be deployed in the internal pudendal artery, with a 1:1 ratio of both proximal and distal segments.

Start Date01 Jul 2015

Sponsor / Collaborator

National Taiwan University Hospital

[+1]

NCT02472431

/ CompletedPhase 1/2IIT

Effectiveness and Safety of Intracavernosal Administration of Autologous Adipose-Derived Regenerative Cells for Treatment of Erectile Dysfunction

Autologous adipose-derived regenerative cells (ADRC) extracted using Celution 800/CRS System (Cytori Therapeutics Inc) from a portion of the fat harvested from the patient's front abdominal wall. ADRC will be administered one-time intracavernosally. This is a single arm study with no control. All patients receive cell therapy.

Start Date01 Apr 2015

Sponsor / Collaborator

I.M. Sechenov First Moscow State Medical University

100 Clinical Results associated with Impotence, Vasculogenic

100 Translational Medicine associated with Impotence, Vasculogenic

0 Patents (Medical) associated with Impotence, Vasculogenic

363

Literatures (Medical) associated with Impotence, Vasculogenic

03 Jan 2025·The Journal of Sexual Medicine

Penile suspensory ligament: anatomy, function, and clinical perspectives of its repair

Review

Author: Blecher, Gideon ; Liu, Wen ; Calopedos, Ross ; Love, Christopher

AbstractBackgroundThe penile suspensory ligament (PSL) plays a significant role in penile support and erection and its injury or congenital absence may result in functional impairment of erectile function.AimTo describe the diagnosis and surgical repair technique for PSL abnormalities and overall outcomes.MethodsA comprehensive review of the literature was performed to understand the anatomic relevance of the PSL and historical management of PSL defects. A contemporary method for PSL repair is described using a transverse infrapubic incision with placement of midline anchoring (non-absorbable braided) sutures between the tunica albuginea (TA) and symphysis pubis to correct penile position and instability.OutcomesSurgical success defined as degree of penile curvature and penile stability for sexual intercourse as well as patient and partner satisfaction rates were reviewed.ResultsThough limited in number, available case series in the literature indicate a success rate between 85-100%, and more recent reviews fall in the 85-91% range. Patient satisfaction rates vary from 82-88%, but some series included patients with penile dysmorphic disorder and Peyronie’s disease, which are known to have higher dissatisfaction rates related to the underlying etiology itself. In patients with venogenic erectile dysfunction (ED), resolution was 100% but de novo ED occurred in 3-5%; these cases were all successfully managed medically.Clinical ImplicationsThis review addresses the diagnosis of PSL abnormalities and demonstrates a simple but effective repair technique to significantly improve erectile stability in men with acceptable risk.Strengths and LimitationsThis is a comprehensive review of the available research on PSL abnormalities that outlines its diverse patient presentation and a systematic method to diagnosis and repair PSL defects. The patient satisfaction rates are reasonably high but given the relatively rarity of this entity, larger longitudinal multi-institutional studies are required to further elucidate risks of de novo ED, penile shortening, and functional outcomes over the long-term.ConclusionPSL repair using permanent anchoring sutures or a fascial graft between the pubic symphysis and the TA of the corpora cavernosa is a safe and efficacious way to restore an important part of the penile suspensory apparatus that helps stabilize the penis during erection for normal sexual function.

01 Dec 2024·Dermatologic Surgery

Successful Treatment of Penile Venous Malformation With a 577-nm Laser

Article

Author: Bayramgürler, Dilek ; Kazan, Didem

15 Jul 2024·2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Development of an electro-pneumatic calf muscle actuator to estimate peripheral venous oxygen saturation using photoplethysmography

Article

Author: Leonhardt, Steffen ; Noppeney, Stefan ; Blazek, Vladimir ; Badiola, Idoia ; Lueken, Markus

In pulse oximetry, arterial blood pulsations are used to estimate peripheral arterial oxygen saturation (SpO2) using photoplethysmography (PPG). On the contrary, peripheral venous oxygen saturation (SvO2) assessment remains challenging due to the absence of rhythmic blood volume fluctuations in the venous system. This paper introduces an electro-pneumatic system emulating the Venous Muscle Pump Test (VMPT) to induce venous blood pulsations. The system achieves 0-120 mmHg pressure pulsations on the calf at 0.5 Hz, facilitating SvO2 estimation through a toe-attached PPG sensor. A proof-of-concept study on two subjects reveals PPG curves and venous blood volume variations comparable to conventional VMPT. The system outperforms in acquiring arterial pulsations, enabling simultaneous SpO2 estimation and the possibility of local oxygen consumption estimation. Estimated Ratio-of-Modulation and SvO2 values (84-89 %) align with classical VMPT, with lower mean deviation (3-15 % vs. 10-18 %). While promising, further studies with larger sample sizes, varied pressure parameters, and reference SvO2 values are essential for validating the system's efficacy. Future tests will further explore the system's potential to detect venous valve leakage.

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