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Last update 08 May 2025

Valinemia

Last update 08 May 2025

Basic Info

Synonyms

HYPERVALINEMIA, High blood valine concentration, Hypervalinaemia

+ [13]

Introduction

An increased concentration of valine in the blood. [HPO_CONTRIBUTOR:gcarletti]

Drugs associated with Valinemia

AZD-3839

Target

BACE x BACE1

Mechanism

BACE inhibitors [+1]

Active Org.-

Originator Org.

AstraZeneca Pharmaceuticals Co. Ltd.

Active Indication-

Inactive Indication

Alzheimer Disease [+1]

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Valinemia

NCT01348737

/ CompletedPhase 1

A Phase I, Randomised, Double-blind, Placebo-controlled, Parallel-group Single Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on Biomarkers of AZD3839 Including an Open-label Food Effect Group in Healthy Male and Female Volunteers of Non-childbearing Potential

The purpose of the study is to assess the safety, tolerability and blood concentration of AZD3839 following oral administration of single doses in healthy men and women of non-childbearing potential

Start Date01 Jun 2011

Sponsor / Collaborator

AstraZeneca PLC

100 Clinical Results associated with Valinemia

100 Translational Medicine associated with Valinemia

0 Patents (Medical) associated with Valinemia

Literatures (Medical) associated with Valinemia

01 Jun 2025·Poultry Science

Valine and isoleucine deficiency in necrotic enteritis challenge impact growth performance, intestinal health, and muscle growth in broilers

Article

Author: Goo, Doyun ; White, Dima L ; Choi, Janghan ; Ko, Hanseo ; Kim, Woo K ; Lee, Jihwan ; Sharma, Milan K

Necrotic enteritis (NE), an enteric disease caused by Clostridium perfringens, and antagonistic effects due to dietary branched-chain amino acid (BCAA) imbalance are key factors that negatively affect chicken growth. The current study was conducted to investigate the effects of valine and isoleucine deficiency in NE challenged broilers. A total of 336 seven-d-old male Cobb 500 were allotted to four treatments with six replicates. The four treatments were as follows: (1) non-challenged control (NC; leucine:lysine = 1.31, valine:lysine = 0.73, and isoleucine:lysine = 0.63), (2) NE-challenged group (NE), (3) NE-challenged with 85 % valine deficiency group (NE-VAL; valine:lysine = 0.62), and (4) NE-challenged with 85 % isoleucine deficiency group (NE-ILE; isoleucine:lysine = 0.54). E. maxima and C. perfringens were administered on d 14 and 18, respectively, and the experiment lasted until d 21. The NE-VAL group had the lowest growth performance measurements compared to the other groups (P < 0.001). All NE-challenged groups had significantly reduced overall growth performance measurements compared to the NC group (P < 0.001). The NE-ILE group showed no difference in any of the measurements compared to the NE group. On d 21, the NE group had significantly increased intestinal permeability, jejunal lesion scores, C. perfringens colony counts, and jejunal chemokine and cytokine gene expression levels, along with decreased intestinal morphology compared to the NC group (P < 0.05). The NE-VAL group had significantly decreased breast muscle yield, reduced lean and total tissue weight, and increased expression levels of mechanistic target of rapamycin pathway and BCAA catabolism-related genes compared to the NE group (P < 0.05). This may explain why the NE-VAL group had the lowest growth performance, as the two negative effects of NE infection and valine deficiency are separated. In conclusion, the negative effects of NE challenge and valine deficiency were independent; valine deficiency showed a similar response to that exhibited by high leucine levels, despite reduced feed intake caused by NE challenge.

01 Feb 2025·Poultry Science

Valine deficiency has a greater impact on broiler growth and bone health than isoleucine deficiency

Article

Author: Goo, Doyun ; Kim, Woo Kyun

Valine and isoleucine are not only two of the indispensable amino acids (AAs) in chickens but also have special mechanisms with leucine within the branched-chain AA (BCAA) category. Therefore, we aimed to investigate how valine or isoleucine deficiency could specifically affect growth performance in broilers through various analyses. A total of 252 seven-day (d)-old male Cobb 500 broilers were allotted to three treatments with six replicates and reared until d 21. The three treatments were as follows: (1) Control group (CON; 1.31 leucine:lysine ratio), (2) valine deficiency group (-VAL; 0.62 valine:lysine ratio and 85% valine level compared to the CON group), and (3) isoleucine deficiency group (-ILE; 0.54 isoleucine:lysine ratio and 85% isoleucine level compared to the CON group). The -VAL group had significantly decreased d 7, 14, and 21 body weight (BW), BW gain (BWG), feed intake (FI), and feed efficiency from d 7 to 21 compared to the CON and -ILE groups (P < 0.001). The -ILE group showed no difference in d 14 and 18 BW; however, they showed significantly reduced BW and BWG at d 21 and feed efficiency from d 7 to 21 compared to the CON group (P < 0.001). Daily FI in the -VAL group significantly decreased from the beginning compared to the two groups, and this gap further expanded until d 21. The -VAL group also had significantly decreased breast muscle weight, total tissue weight, bone mineral density, bone mineral content, and walking ability (P < 0.01). The expression levels of mechanistic target of rapamycin and BCAA catabolism-related genes were highest in the -VAL group (P < 0.05), whereas the -ILE group did not show any difference compared to the CON group (P > 0.05). In conclusion, about 85% valine deficiency is accompanied by a substantial reduction in chicken growth, which has a much greater effect than isoleucine. Valine deficiency can also lead to increased utilization of leucine, which may result in BCAA antagonism.

01 Jan 2017·International Journal of Trichology

Prevalence of nutritional deficiencies in hair loss among Indian participants: Results of a cross-sectional study

Article

Author: Gowda, Dinesh ; Imtiyaz, D B ; Premalatha, V

BACKGROUNDNutritional deficiencies are known to be associated with hair loss; however, the exact prevalence is not known.AIMSThe aim of this study is to evaluate the prevalence of nutritional deficiencies in participants with hair loss.MATERIALS AND METHODSIn this cross-sectional study, 100 enrolled participants were divided into telogen effluvium (TE), male-pattern hair loss (MPHL), and female-pattern hair loss (FPHL) based on the type of hair loss. All participants underwent laboratory estimation for micronutrients and amino acid levels.RESULTSParticipants with hair loss showed varied amino acid and micronutrient deficiencies across all types of hair loss. Nutritional status did not vary much between the types of hair loss. Among the essential amino acids, histidine deficiency was seen in >90% of participants with androgenic alopecia and 77.78% of participants with TE while leucine deficiency was seen 98.15% of participants with TE and 100% with FPHL. Valine deficiency was also very common across alopecia subtypes. Among the nonessential amino acids, alanine deficiency was observed in 91.67% FPHL, 91.18% MPHL, and 90.74% TE. Cysteine deficiency was present in 55.58% and 50% of participants with MPHL and TE, respectively. A relatively higher proportion of participants with TE had iron deficiency compared to androgenic alopecia (P = 0.069). Zinc deficiency was seen in 11.76% of participants with MPHL while copper deficiency was seen in 29.41% and 31.48% of participants with MPHL and TE, respectively.CONCLUSIONNutritional deficiency is a common problem in participants with hair loss irrespective of the type of alopecia. The findings of our study suggest need for identification and correction of nutritional deficiencies in patients with hair loss.

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Valinemia

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