Brain Injuries

The test, run on Abbott's portable i-STAT® Alinity® hand-held instrument, uses whole blood to help evaluate patients 18 years of age and older with a suspected mild traumatic brain injury, or concussion, producing lab-quality results in 15 minutes The test will be used by healthcare professionals in the medical facilities at all MotoAmerica races in 2025 ABBOTT PARK, Ill., and IRVINE, Calif., May 1, 2025 /PRNewswire/ -- Abbott (NYSE: ABT), the global healthcare company, and MotoAmerica, the premier motorcycle road racing series in North America, announced today that MotoAmerica is the first professional sports organization worldwide to use Abbott's groundbreaking blood test to help assess suspected concussions for riders in the on-site medical facilities at all races. Abbott's test, the i-STAT TBI test cartridge, is used to evaluate patients 18 years of age and older who present with suspected mild traumatic brain injury (mTBI). It provides results in 15 minutes and may be used up to 24 hours after injury to help determine the need for a CT scan of the head. In 2024, Abbott's i-STAT TBI test received clearance from the U.S. Food and Drug Administration (FDA) to be used with whole blood, allowing doctors to quickly assess patients with suspected mTBI on the handheld i-STAT Alinity analyzer at the patient's side. "This is the first ever objective test that physicians have had at the point-of-care to assist in the assessment of concussions – it changes the game," said Carl Price, M.D., chief medical officer for MotoAmerica. "If a crash or fall does happen, the ability to quickly and objectively determine whether or not a rider needs a CT scan or additional evaluation, right there on-site, provides us—and our riders—with peace of mind." The i-STAT TBI test cartridge will be available in on-site medical facilities for all MotoAmerica races across the U.S. during the 2025 season, beginning with the race at Michelin Raceway Road in Atlanta, Ga. (May 2-4). "As both a neurologist and licensed physician, I know firsthand the limitations of relying on a subjective tool like the Glasgow Coma Scale in the assessment of brain injury," said Beth McQuiston, M.D., medical director in Abbott's diagnostics business. "The ability to objectively assess the need for a head CT scan following potential brain injury right at the point of care, whether that be at a hospital bedside or an on-site medical facility at a sporting event, means quick assessment and a quick path to the right treatment." At MotoAmerica, riders wear comprehensive protection, including airbag-equipped suits that inflate on impact, helmets tested for multiple impact forces, and full-body armor. The tracks also feature air fence barriers and a dedicated medical safety car. In the event of a crash or fall, immediate on-site assessment adds an extra layer of safety to determine if a rider requires a CT scan or further evaluation. "The standard of competition and performance in MotoAmerica continues to increase," said Chuck Aksland, chief operating officer, MotoAmerica. "Between the riders, the motorcycles, their gear, and now accessibility to the most innovative medical equipment, we continue to push our standards and practices to better protect our racers. Our use of Abbott's rapid blood test for concussion assessment furthers this commitment and will help us evaluate medical needs quickly and on location." According to the National Institutes of Health (NIH), traumatic brain injury from accidents or sports is a leading cause of death and disability in the United States. The Centers for Disease Control and Prevention (CDC) estimates 2.5 million people visit the emergency department for TBIs every year. How the test works The i-STAT TBI test cartridge with the i-STAT Alinity System requires a small venous blood sample – just a few drops applied to the test cartridge. The cartridge is then inserted into the portable i-STAT Alinity instrument. The test measures two brain-specific biomarkers that are released into the blood stream when there is a significant brain injury. If neither of these biomarkers measured are above an established cutoff, a significant injury has likely not occurred, and a CT scan can likely be avoided. Testing for these two biomarkers – ubiquitin C-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) – following an injury can provide essential and objective information about a patient's condition and can help healthcare providers decide an appropriate treatment plan. The test was developed by Abbott, with support from the U.S. Army Medical Research and Development Command's (USAMRDC) U.S. Army Medical Materiel Development Activity (USAMMDA) and in collaboration with Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI). The ability to use whole blood to help assess patients with suspected mTBI is an important step in Abbott's vision to make its tests available in all settings where people seek care for head injuries. Today, the test is available to be used by hospitals, clinics, and any athletic organization with trained medical staff on-site and the ability to run moderately complex testing. Research and planning are ongoing to determine the feasibility of using these biomarkers similarly in teens and children. About MotoAmerica: MotoAmerica is officially sanctioned by the American Motorcyclist Association (AMA) and the Fédération Internationale de Motocyclisme (FIM), and it features nine classes of motorcycle road racing: Superbike, Supersport, King of the Baggers, Talent Cup, Super Hooligan, Stock 1000, Twins Cup, Build. Train. Race. and Mini Cup. About Abbott: Abbott is a global healthcare leader that helps people live more fully at all stages of life. Our portfolio of life-changing technologies spans the spectrum of healthcare, with leading businesses and products in diagnostics, medical devices, nutritionals and branded generic medicines. Our 114,000 colleagues serve people in more than 160 countries. Connect with us at and on LinkedIn, Facebook, Instagram, X and Youtube. The i-STAT TBI test cartridge was developed with support by the U.S. Department of Defense U.S. Army Medical Research and Development Command's (USAMRDC) U.S. Army Medical Materiel Development Activity (USAMMDA). The USAMRDC has been dedicated to developing a solution for the objective detection and evaluation of TBI for more than two decades and has played a critical role in developing the TBI test on Abbott's i-STAT Alinity platform. (Reference to USAMRDC and USAMMDA does not imply or constitute endorsement by these organizations or by the Department of Defense or the U.S. Army.) The Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) research team was the first to demonstrate how this TBI blood test can be used for the benefit of TBI patients in clinical care. SOURCE Abbott WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Ad Hoc Announcement Pursuant to Art. 53 LR Geneva, Switzerland, April 30, 2025 - Addex Therapeutics (SIX/NASDAQ: ADXN), a clinical-stage biopharmaceutical company focused on developing a portfolio of novel small molecule allosteric modulators for neurological disorders, announced today that it has entered into an option- and collaboration agreement with Sinntaxis AB (www.sinntaxis.com) for an exclusive license to intellectual property covering the use of metabotropic glutamate receptor subtype 5 (mGlu5) inhibitors for the treatment of brain injury recovery. The agreement also includes a research collaboration under which the Sinntaxis team will complete evaluation of Addex’s dipraglurant, an orally active mGlu5 negative allosteric modulator (NAM), for the treatment of brain injury recovery. “Dipraglurant is a key clinical asset for Addex and this agreement with Sinntaxis is key to our strategy to reposition dipraglurant in this significant unmet medical need. Under the collaboration, we will complete the preclinical validation of dipraglurant in models of brain injury recovery building on the data already published in Brain last year,” said Tim Dyer, CEO of Addex. “Our previous clinical studies in other indications have shown dipraglurant to be safe, well tolerated and highly selective towards the mGlu5 receptor, so we believe it could be a promising clinical candidate to treat functional recovery in patients including those with stroke or traumatic brain injury.” Under the terms of the agreement, Addex will pay Sinntaxis an undisclosed option fee to obtain an exclusive license to access intellectual property rights that Sinntaxis holds covering the use of mGlu5 NAMs to improve recovery of function in patients suffering from brain damage or injury as the result of a stroke or other brain trauma. The agreement also includes a collaboration under which Sinntaxis will execute a research plan to complete the preclinical evaluation and contribute expertise in designing clinical plans. “With dipraglurant, Addex has a promising candidate ready for clinical evaluation to help patients with brain injury recover better. We have been evaluating the role that the mGlu5 receptor plays in modulating brain plasticity and function for some time and are looking forward to adding our expertise to the development acumen of Addex so that we can move quickly towards clinical evaluation,” said Tadeusz Wieloch, CEO of Sinntaxis. About mGluR5 NAMs and Brain InjuryFunctional recovery following stroke relies on the formation of new or reactivation of existing neural connections. Accumulating evidence suggests that the mGlu5 receptor modulates brain plasticity and function. A paper published in BRAIN*, titled “Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity”, showed that daily treatment with mGlu5 NAMs for 12 days, starting 2 or 10 days after stroke, restored lost somatosensory functions without diminishing infarct size. Within hours of treatment, somatosensory recovery expressed in normalized use of affected limbs, was apparent and progressed for the subsequent 12 days. Furthermore, brain-wide disruptions in resting-state functional connectivity after stroke were reversed by mGlu5 inhibition in distinct sensorimotor cortices contralateral to the lesion and bilaterally in visual cortices. * Brain, Volume 147, Issue 1, January 2024, Pages 186–200 About Addex: Addex Therapeutics is a clinical-stage biopharmaceutical company focused on developing a portfolio of novel small molecule allosteric modulators for neurological disorders. Addex’s lead drug candidate, dipraglurant (mGlu5 negative allosteric modulator or NAM), is under evaluation for future development in brain injury recovery, including post-stroke and traumatic brain injury recovery. Addex’s partner, Indivior, has selected a GABAB PAM drug candidate for development in substance use disorders. Addex is advancing an independent GABAB PAM program for chronic cough. Addex also holds a 20% equity interest in a private company, Neurosterix LLC, which is advancing a portfolio of allosteric modulator programs, including M4 PAM for schizophrenia, mGlu7 NAM for mood disorders and mGlu2 NAM for mild neurocognitive disorders. Addex shares are listed on the SIX Swiss Exchange and American Depositary Shares representing its shares are listed on the NASDAQ Capital Market, and trade under the ticker symbol “ADXN” on each exchange. For more information, visit www.addextherapeutics.com Contacts: Tim DyerChief Executive OfficerTelephone: +41 22 884 15 55PR@addextherapeutics.com Mike SinclairPartner, Halsin Partners+44 7968 022075msinclair@halsin.com Addex Forward Looking Statements:This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including statements about the intended use of proceeds of the offering. The words “may,” “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “target” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release, are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, uncertainties related to market conditions. These and other risks and uncertainties are described in greater detail in the section entitled “Risk Factors” in Addex Therapeutics’ Annual Report on Form 20-F for the year ended December 31, 2023, as filed with the SEC on April 18, 2024, the final prospectus supplement and accompanying prospectus and other filings that Addex Therapeutics may make with the SEC in the future. Any forward-looking statements contained in this press release represent Addex Therapeutics’ views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date. Addex Therapeutics explicitly disclaims any obligation to update any forward-looking statements.

Bringing Advanced Hyperbaric Oxygen Therapy to More Communities Across the State NEW YORK, April 28, 2025 /PRNewswire/ -- MD Hyperbaric, a leading provider of medical-grade Hyperbaric Oxygen Therapy (HBOT), proudly announces the opening of two new advanced care facilities in New York: one in Purchase and one in the greater Syracuse area. These new centers mark a significant milestone in the company's ongoing mission to make cutting-edge wellness and recovery therapies more accessible to patients throughout the state. Continue Reading MD Hyperbaric provides medical-grade hyperbaric oxygen therapy (HBOT) services to help optimize the health and recovery of patients. The Purchase center, located at 3010 Westchester Avenue, Suite 400, offers Westchester County residents access to scientifically supported HBOT protocols for a wide range of conditions—from traumatic brain injuries and post-surgical recovery to long COVID and chronic illnesses. Meanwhile, the new Syracuse location, situated in the Shoppes at Town Center in Fayetteville, introduces state-of-the-art hyperbaric services to the Central New York region. "Hyperbaric oxygen therapy has shown remarkable results in accelerating healing and improving quality of life," said Thomas Eaton, owner of MD Hyperbaric Westchester. "We are excited to bring this level of medically supervised, medical-grade treatment into the community." With five centers now open—and three more on the way—MD Hyperbaric is entering a period of rapid expansion, driven by increasing demand for HBOT's proven benefits. Treatments involve breathing pure oxygen in a pressurized chamber, which enhances the body's natural healing processes at the cellular level. Patients have seen improvements in everything from neurological function and cognitive performance to energy levels, surgical recovery, and chronic pain management. "Our goal is to democratize access to the highest standard of care in hyperbaric oxygen therapy," said Chris Neal, CEO of MD Hyperbaric. "These new openings represent a critical step in delivering personalized, physician-supervised wellness solutions to more people across New York." Each location features the latest in hyperbaric chamber technology, with care overseen by licensed medical professionals and certified hyperbaric technicians in a modern, comfortable setting. Media, healthcare professionals, and community members are invited to tour the facilities and learn more about the benefits of HBOT. For more information or to book an appointment, visit or contact the locations directly: Purchase, NY: (914) 377-5955 Syracuse, NY: (315) 234-4106 About MD Hyperbaric MD Hyperbaric is a premier provider of hyperbaric oxygen therapy, committed to enhancing health and wellness through advanced therapeutic techniques. With a growing network of locations, MD Hyperbaric is dedicated to delivering exceptional care and innovative solutions to support optimal recovery and overall well-being. For more information, visit . SOURCE MD Hyperbaric WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED