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Last update 08 May 2025

Carrington Syndrome

Last update 08 May 2025

Basic Info

Synonyms

Carrington syndrome, Carrington's Disease, Carrington's pulmonary eosinophilia

+ [9]

Introduction

A rare, severe, interstitial lung disease characterized by insidious onset with subacute or chronic non-specific respiratory manifestations (dyspnea, cough, wheezing) often associated with systemic manifestations (fatigue, malaise, weight loss) and a history of asthma (up to half of patients). Eosinophilia is present in most cases, usually in excess of 1000 cells/mm3.

Clinical Trials associated with Carrington Syndrome

JPRN-UMIN000019092

/ CompletedNot ApplicableIIT

Prediction of lung function decline in chronic eosinophilic pneumonia - Prediction of lung function decline in CEP

Start Date22 Sep 2015

Sponsor / Collaborator-

JPRN-UMIN000020887

/ RecruitingNot ApplicableIIT

Investigation of eosinophil activating factor in bronchoalveolar lavage fluid of acute eosinophilic pneumonia - Investigation of eosinophil activating factor in bronchoalveolar lavage fluid of acute eosinophilic pneumonia

Start Date01 Mar 2015

Sponsor / Collaborator

Saitama Medical University

NCT01152424

/ Unknown statusNot ApplicableIIT

Usefulness of Exhaled NO in the Differential Diagnosis Acute Eosinophilic Pneumonia and Community Acquired Pneumonia

Acute eosinophilic pneumonia (AEP) is diagnosed by cell count analysis of bronchoalveolar lavage fluid. However, the performance of bronchoscopy is not easy for patients with AEP, because they usually have hypoxia. Exhaled nitric oxide (FeNO) is usually elevated in the patients with eosinophilic inflammation such as asthma, but there is no previous studies FeNO in the patients with AEP. Investigators hypothesized that FeNO elevated significantly in patients with AEP, and FeNO can be used as non-invasive diagnostic method in patients who are clinically suspected with AEP, especially when the performance of bronchoscopy is difficult.

Start Date01 Jul 2010

Sponsor / Collaborator

Seoul National University Bundang Hospital

100 Clinical Results associated with Carrington Syndrome

100 Translational Medicine associated with Carrington Syndrome

0 Patents (Medical) associated with Carrington Syndrome

925

Literatures (Medical) associated with Carrington Syndrome

01 Apr 2025·Clinical Case Reports

From Medication to Complication: A Case Report of Acute Eosinophilic Pneumonia Associated With Naltrexone

Article

Author: Davoodi, Amir ; Guma, Jenna ; Ren, Shuyue ; Bordogna, Amy ; Haroldson, Kathryn

ABSTRACTNaltrexone, increasingly used for substance use disorders, can induce acute eosinophilic pneumonia. Prompt recognition through exclusion of other causes and early corticosteroid initiation can ensure rapid improvement and prevent severe complications.

10 Mar 2025·Cureus

A Diagnostic Dilemma: Proteinase-3 (PR3)-Positive Anti-neutrophil Cytoplasmic Autoantibodies in Eosinophilic Granulomatosis With Polyangiitis

Article

Author: White, Tara ; Awan, Kanwal ; Williams, Matthias ; Wilson, Benjamin ; Goldman, Samuel

Eosinophilic granulomatosis with polyangiitis (EGPA) is a multifaceted diseased vasculitis typically associated with myeloperoxidase-perinuclear-anti-neutrophil cytoplasmic antibody (+MPO-P-ANCA). Although rare, the diagnosis should be considered in patients with difficult-to-control or late-onset asthma and extrathoracic disease. We present the case of a 37-year-old male with adult-onset asthma and chronic rhinitis hospitalized with pancreatitis and hypoxemia. Blood investigations demonstrated eosinophilia with elevated lipase, and bronchoscopy demonstrated multiple endobronchial lesions with elevated eosinophils on bronchoalveolar lavage. In addition, labs showed proteinase 3-specific antineutrophil cytoplasmic antibody (PR3-C-ANCA) autoantibodies, and the patient was diagnosed with EGPA. Additional differential diagnoses of parasitic infection, sarcoidosis, chronic eosinophilic pneumonia, and granulomatosis with polyangiitis (GPA) were entertained, but ultimately, the multisystemic involvement, anti-neutrophil cytoplasmic autoantibody (ANCA) positivity, bronchoscopy, and imaging findings clinched the diagnosis. This case highlights the spectrum of possible EGPA presentations and a rare case of PR3-C-ANCA with gastrointestinal manifestations.

01 Mar 2025·Respirology Case Reports

Spontaneous Pneumothorax Secondary to Pulmonary Paragonimiasis: A Case Report Highlighting Diagnostic Delay in Eastern Nepal

Article

Author: Rupak, K. C. ; Sah, Sandip Kumar ; Adhikari, Bigyan ; Pokhrel, Ashit ; Mahato, Arun Kumar ; Shah, Sonu

ABSTRACTParagonimiasis, or oriental lung fluke, a zoonotic disease acquired by consuming raw or undercooked crustaceans such as crabs or snails, can mimic tuberculosis in endemic regions. There is a wide range of clinical symptoms depending on the parasite location, from non‐specific symptoms like diarrhoea, abdominal pain, rash, and fever to pleuropulmonary symptoms like cough, haemoptysis, chest pain, and dyspnoea. Pneumothorax is the rare clinical picture. We present a case of a 48‐year‐old male non‐smoker with a persistent cough for 3 months and who was treated for acute eosinophilic pneumonia initially at another centre. He then presented with symptoms of spontaneous pneumothorax at our centre and was treated with a chest tube. Revisiting the history, raw snail consumption was noted. Microscopic examination of a wet mount bronchoalveolar lavage (BAL) confirmed the diagnosis of Paragonimus westermani, and praziquantel was started; he improved significantly within 48 h.

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Carrington Syndrome

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