Last update 01 Nov 2024

Leprosy, Tuberculoid

Last update 01 Nov 2024

Basic Info

Synonyms

Full tuberculoid leprosy, Hansen病-神経, Hansen病-結核様

+ [60]

Introduction

A principal or polar form of LEPROSY in which the skin lesions are few and are sharply demarcated. Peripheral nerve involvement is pronounced and may be severe. Unlike lepromatous leprosy (LEPROSY, LEPROMATOUS), the lepromin test is positive. Tuberculoid leprosy is rarely a source of infection to others.

Clinical Trials associated with Leprosy, Tuberculoid

CTRI/2023/12/060545 / Not yet recruitingPhase 4

Molecular Mechanisms of Immunomodulation Imparted by Mycobacterium indicus pranii (MIP) vaccine against multibacillary leprosy - M2I2MIP

Start Date29 Dec 2023

Sponsor / Collaborator

Leprosy Research Initiative

RBR-88jm8yk / Not yet recruitingPhase 1/2IIT

Clinical Trial for the Assessment of Safety, Tolerance and Immune Responses toVaccine, for the Prevention of Leprosy, LepVax in Adult Participants

Start Date04 Jan 2022

Sponsor / Collaborator

Fundação Oswaldo Cruz

CTRI/2021/08/035644 / Not yet recruitingNot ApplicableIIT

A Quasi experimental study to assess the effectiveness of Nurse-led interventions on treatment adherence, quality of life and psychosocial issues among adult leprosy patients attending leprosy clinic, PGIMER, Chandigarh 2020-22.

Start Date16 Aug 2021

Sponsor / Collaborator-

100 Clinical Results associated with Leprosy, Tuberculoid

100 Translational Medicine associated with Leprosy, Tuberculoid

0 Patents (Medical) associated with Leprosy, Tuberculoid

1,098

Literatures (Medical) associated with Leprosy, Tuberculoid

01 Oct 2024·eBioMedicine

Cellular and molecular determinants of bacterial burden in leprosy granulomas revealed by single-cell multimodal omics

Article

Author: Guo, Dianhao ; Liao, Xiaojie ; Modlin, Robert L. ; Mi, Zihao ; Wang, Yi ; Modlin, Robert L ; Wang, Jianwen ; Zhang, Furen ; Wang, Zhenzhen ; Lin, Yingjie ; Wang, Chuan ; Liu, Tingting ; Sun, Lele ; Liu, Jianjun ; Xue, Xiaotong ; Liu, Hong

BACKGROUNDWhich cell populations that determine the fate of bacteria in infectious granulomas remain unclear. Leprosy, a granulomatous disease with a strong genetic predisposition, caused by Mycobacterium leprae infection, exhibits distinct sub-types with varying bacterial load and is considered an outstanding disease model for studying host-pathogen interactions.METHODSWe performed single-cell RNA and immune repertoire sequencing on 11 healthy controls and 20 patients with leprosy, and integrated single-cell data with genome-wide genetic data on leprosy. Multiplex immunohistochemistry, and in vitro and in vivo infection experiments were conducted to confirm the multimodal omics findings.FINDINGSLepromatous leprosy (L-LEP) granulomas with high bacterial burden were characterised by exhausted CD8⁺ T cells, and high RGS1 expression in CD8⁺ T cells was associated with L-LEP. By contrast, tuberculoid leprosy (T-LEP) granulomas with low bacterial burden displayed enrichment in resident memory IFNG⁺ CD8⁺ T cells (CD8⁺ Trm) with high GNLY expression. This enrichment was potentially attributable to the communication between IL1B macrophages and CD8⁺ Trm via CXCL10-CXCR3 signalling. Additionally, IL1B macrophages in L-LEP exhibited anti-inflammatory phenotype, with high APOE expression contributing to high bacterial burden. Conversely, IL1B macrophages in T-LEP were distinguished by interferon-γ induced GBP family genes.INTERPRETATIONThe state of IL1B macrophages and functional CD8⁺ T cells, as well as the relationship between them, is crucial for controlling bacterial persistence within granulomas. These insights may indicate potential targets for host-directed immunotherapy in granulomatous diseases caused by mycobacteria and other intracellular bacteria.FUNDINGThe Key research and development program of Shandong Province (2021LCZX07), Natural Science Foundation of Shandong Province (ZR2023MH046), Youth Science Foundation Cultivation Funding Plan of Shandong First Medical University (Shandong Academy of Medical Sciences) (202201-123), National Natural Science Foundation of China (82471800, 82230107, 82273545, 82304039), the China Postdoctoral Science Foundation (2023M742162), Shandong Province Taishan Scholar Project (tspd20230608), Joint Innovation Team for Clinical & Basic Research (202410), Central guidance for local scientific and technological development projects of Shandong Province (YDZX2023058).

01 Mar 2024·JAAD Case Reports

Morbihan disease-like presentation of tuberculoid leprosy

Author: Al-Omair, Abdullah ; Al Busair, Moath ; Al Sadhan, Abdulaziz ; Alhumidi, Ahmed

01 Feb 2024·Orthopaedic Journal of Sports Medicine

Change in Posterior Tibial Slope Angle After Displaced Pediatric Tibial Tubercle Fracture: A Model for Growth Modulation in the ACL-Deficient Knee

Article

Author: Vasudevan, Rajiv S. ; Pennock, Andrew T. ; Paras, Tyer ; Zogby, Andrew M. ; Wilps, Tyler

Background: Increased posterior tibial slope angle (PTSA) has been shown to be an important risk factor for anterior cruciate ligament (ACL) injury. PTSA modulation is not utilized routinely to reduce risk of primary rupture or graft failure. Displaced tibial tubercle (TT) fractures in the skeletally immature are associated with potential growth arrest and may be used as a model to study PTSA changes in this setting. Purpose/Hypothesis: To quantify the change in PTSA (ΔPTSA) after operative treatment of displaced TT fractures in skeletally immature patients. It was hypothesized that there would be a progressive decrease in PTSA after TT injury and that rate of ΔPTSA would be highest during peak growth velocity. Study Design: Case series; Level of evidence, 4. Methods: Included were 22 patients (n = 23 knees; mean chronological and bone age at injury, 14 years; 86% male) who underwent surgery for displaced TT fracture. PTSA was measured on lateral radiographs at time of surgery and subsequent follow-up, and bone age at the time of injury was determined using radiographic standards. The rate of ΔPTSA for individual patient, total cohort, and sex-based subgroup trends were determined via linear regression (degrees per month; positive value indicates relatively anterior). Individual patient regression coefficients were averaged into bone age cohorts. Results: Average follow-up was 17 months (range, 6-52 months). The mean PTSA was -12°± 2.4° at the time of injury, and the mean ΔPTSA for the cohort was 0.30°± 0.31° per month (range, -0.27° to 0.97° per month). Linear regression demonstrated a significant relationship between months postfixation and PTSA, demonstrating a ΔPTSA of 0.31° per month (95% confidence interval [CI], 0.24° to 0.38°; P < .001). The highest ΔPTSA was seen at bone age 14 years (mean, 0.58°± 0.44° per month). The mean absolute change in PTSA from injury to final follow-up was 4.1° (range, -3.4° to 21°). Conclusion: Our data suggested that PTSA becomes more anterior after operatively treated pediatric TT fractures and that ΔPTSA may be influenced by bone age. This concept may be useful in considering surgical modulation of excessive PTSA in the pediatric ACL-deficient knee.

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Leprosy, Tuberculoid

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