Yellow Nail Syndrome

Last update 23 Jan 2025

Basic Info

Synonyms

Hereditary lymphedema and yellow nails, Hereditary lymphedema and yellow nails (disorder), Hereditary lymphoedema and yellow nails

+ [29]

Introduction

A rare condition characterized by the presence of yellow nails, LYMPHEDEMA, and/or PLEURAL EFFUSION with respiratory tract involvement. Abnormal lymphatic network may play a role in its etiology. Occasionally inherited, yellow nail syndrome mostly is sporadic without apparent family history.

Clinical Trials associated with Yellow Nail Syndrome

JPRN-UMIN000028514

/ CompletedNot Applicable

Effectiveness of Clarithromycin in Patients with Yellow Nail Syndrome - Clarithromycin for yellow nail syndrome

Start Date06 Jan 2017

Sponsor / Collaborator

National Center for Global Health & Medicine

100 Clinical Results associated with Yellow Nail Syndrome

100 Translational Medicine associated with Yellow Nail Syndrome

0 Patents (Medical) associated with Yellow Nail Syndrome

456

Literatures (Medical) associated with Yellow Nail Syndrome

18 Sep 2024·Infectious disease reports

A Case of Yellow Nail Syndrome Complicated with Pulmonary Infection Due to Nocardia cyriacigeorgica.

Article

Author: Li, Qiuyu ; Liang, Ying ; Zhu, Hong ; Zheng, Jiajia ; Sun, Yongchang ; Zhang, Qiuyue

Yellow nail syndrome (YNS) is a rare clinical syndrome characterized by nail bed changes, pulmonary involvement, and lymphatic drainage disorders. Pulmonary involvement usually manifests as bronchiectasis, bronchiolitis, and pleural effusion. There are few studies on yellow nail syndrome combined with opportunistic infection. Here, we report a case of clinically diagnosed YNS combined with Nocardia cyriacigeorgica infection and the course of treatment used, which can provide some useful information for clinicians to better understand this rare illness.

01 Sep 2024·Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis

Green Nails, Red Alert: An Unusual Exit site infection Presentation

Article

Author: Kusunose, Kenya ; Sonoda, Shinichiro ; Kohagura, Kentaro ; Aharen, Daigo ; Nakamura, Takuto ; Yamauchi, Marino ; Ikemura, Masaki

Green nail syndrome is an infectious nail disorder caused most commonly by Pseudomonas aeruginosa. We report a rare case of peritoneal dialysis (PD) exit site infection (ESI) accompanied by P. aeruginosa-associated green nail syndrome. The patient was treated with oral and topical antibiotics without the need for PD catheter removal. We aim to emphasise the importance of nail assessment for ESI in patients undergoing PD.

12 Aug 2024·Cureus

A Case Report on the Trilogy of Yellow Nail Syndrome: Yellow Nails, Pleural Effusion, and Lymphedema

Article

Author: Adhikari, Bipin ; Madichetty, Hari G ; Adhikari, Biplab ; Dhital, Alina ; Kanugula, Ashok Kumar

Yellow nail syndrome is a rare medical syndrome characterized by the combination of a triad of yellow nails, recurrent pulmonary manifestations, and lymphedema. All three features of the triad may not be present synchronously. The diagnosis is made clinically once other causes have been excluded. Typically, it occurs in individuals who are 50 years old and above. We report a case of yellow nail syndrome in a 62-year-old male who presented with recurrent episodes of difficulty breathing due to pleural effusion. Further examination revealed pitting edema of the bilateral lower extremities. In the later encounter, his nail was found to be yellowish. Excluding other diagnoses like heart failure, fungal infections, autoimmune diseases, and lung cancer, with a typical triad, a diagnosis of yellow nail syndrome was made. He was managed with pleural fluid tapping for pleural effusion, compression stockings for leg edema, and vitamin E for nail changes. The study also intends to highlight current treatment options and alert physicians of this syndrome with such typical findings.

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Yellow Nail Syndrome

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