Yellow Nail Syndrome

Last update 08 May 2025

Basic Info

Synonyms

Hereditary lymphedema and yellow nails, Hereditary lymphedema and yellow nails (disorder), Hereditary lymphoedema and yellow nails

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Introduction

A rare condition characterized by the presence of yellow nails, LYMPHEDEMA, and/or PLEURAL EFFUSION with respiratory tract involvement. Abnormal lymphatic network may play a role in its etiology. Occasionally inherited, yellow nail syndrome mostly is sporadic without apparent family history.

Clinical Trials associated with Yellow Nail Syndrome

JPRN-UMIN000028514

/ CompletedNot Applicable

Effectiveness of Clarithromycin in Patients with Yellow Nail Syndrome - Clarithromycin for yellow nail syndrome

Start Date06 Jan 2017

Sponsor / Collaborator

National Center for Global Health & Medicine

100 Clinical Results associated with Yellow Nail Syndrome

100 Translational Medicine associated with Yellow Nail Syndrome

0 Patents (Medical) associated with Yellow Nail Syndrome

484

Literatures (Medical) associated with Yellow Nail Syndrome

14 Feb 2025·Cureus

A Case of Distal Nail Embedding Successfully Treated With a Slit-Tape Strap Taping Method

Article

Author: Seo, Takashi ; Muramatsu, Ken ; Kosumi, Hideyuki ; Shiiya, Chihiro ; Ujiie, Hideyuki

Ingrown nails are a common condition, typically affecting the great toe, and are classified into lateral ingrown nails, retronychia, and distal nail embedding (DNE). DNE occurs when the nail plate's distal edge embeds into the nail fold, often following onycholysis or nail avulsion, with hypertrophy of the hyponychium obstructing nail growth. This condition causes nail discoloration, thickening, and pain, requiring treatment to restore proper nail growth. While surgical and conservative treatments are available, conservative approaches such as taping are more accessible but can be hindered by sweat or exudate. The slit-tape strap taping method, originally designed for pincer and lateral ingrown nails, provides superior adherence and longitudinal tension. We report a successful case of this method applied to a 22-year-old woman with DNE, resulting in full resolution of the condition and improvement in nail thickening after 17 months. This case highlights the slit-tape strap taping method as an easy-to-apply, noninvasive, and effective treatment for DNE.

01 Jan 2025·Indian Dermatology Online Journal

The Green Nail Syndrome (“Chloronychia”) in Healthcare Workers: Challenges and Strategies

Article

Author: Vashisht, Kanya Rani

01 Jan 2025·Annals of Internal Medicine

Impaired Wnt/Planar Cell Polarity Signaling in Yellow Nail Syndrome

Article

Author: Stafler, Patrick ; Sofrin-Drucker, Efrat ; Hershkovitz, Dov ; Chermesh, Irit ; Eshach Adiv, Orly ; Avitan-Hersh, Emily ; Baris Feldman, Hagit ; Kurolap, Alina ; Lobmaier, Silvia ; Chai Gadot, Chofit ; Greenberger, Shoshana ; Zohar, Yaniv ; Bugis, Joshua ; Hershkovitz, Tova ; Martin, Ludovic ; Mory, Adi ; Hardak, Emilia ; Schatz, Ulrich A. ; Westphal, Dominik S. ; Geva, Polina ; Shteinberg, Michal ; Chatterji, Sumit ; Humeau, Helene

BACKGROUNDYellow nail syndrome (YNS) is a rare disorder characterized by a triad of yellow dystrophic nails, lymphedema, and chronic lung disease. Most patients present in adulthood, with only a few congenital or familial cases described. The cause of YNS remains largely unknown, although defects in lymphatic vessel development are suggested to play a significant role.OBJECTIVETo elucidate the genetic mechanisms underlying YNS.DESIGNAnalysis of genetic sequencing data and gene and protein expression studies.SETTINGA tertiary care academic medical center.PATIENTS6 patients with congenital YNS (cYNS) and 5 with sporadic YNS (sYNS).MEASUREMENTSExome and genome sequencing were used to detect disease-causing variants, complemented by RNA analyses for intronic variants. Protein and gene expressions were studied by immunofluorescence staining and real-time reverse transcriptase quantitative polymerase chain reaction analyses.RESULTSBiallelic variants in CELSR1 (n = 5) or likely FZD6 (n = 1), both core molecules in the Wnt/planar cell polarity (PCP) pathway, were identified in all patients with cYNS; none of the patients with sYNS had candidate genetic variants. Immunofluorescence staining showed that CELSR1 colocalizes with lymphatic vessels in the skin but not in the lungs or the intestine. Moreover, levels of CELSR1 and FZD6 proteins were negligible to zero in patient tissues (n = 2) compared with control tissues. Gene expression of Wnt/PCP-related genes was reduced in patients with cYNS (n = 3), and patients with sYNS (n = 4) showed milder gene expression impairments.LIMITATIONSmall cohort size and limited sample availability.CONCLUSIONDefects in PCP organization may play a major role in the pathogenesis of YNS. To the authors' knowledge, this is the first demonstration of a mechanism explaining YNS development, mainly in its congenital form but also in patients with sporadic disease.PRIMARY FUNDING SOURCEThe Prof. Baum Research Fund of Israel Lung Association.

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Yellow Nail Syndrome

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