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Last update 08 May 2025

Uterine inflammation

Last update 08 May 2025

Basic Info

Synonyms

UTERINE INFLAMMATION, Uterine inflammation, Uterine inflammation NOS

+ [5]

Introduction-

Drugs associated with Uterine inflammation

GuiZhiFuling Pills

Target-

Mechanism-

Active Org.

Sanwa Shoyaku Co., Ltd. [+3]

Originator Org.

Tsumura & Co.

Active Indication

Amenorrhea [+16]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

Japan

First Approval Date18 Jul 1986

Clinical Trials associated with Uterine inflammation

CTR20202351

/ Not yet recruitingNot Applicable

阿莫西林胶囊人体生物等效性研究

[Translation] Study on the bioequivalence of amoxicillin capsules in healthy volunteers

本试验旨在研究单次空腹和餐后口服湖南安邦制药有限公司研制、生产的阿莫西林胶囊（0.25 g）的药代动力学特征；以LTLファーマ株式会社生产的阿莫西林胶囊（Sawacillin®，250 mg）为参比制剂，比较两制剂中药动学参数Cmax、AUC0-t、AUC0-∞，评价两制剂的人体生物等效性。

[Translation]

The purpose of this study was to study the pharmacokinetic characteristics of amoxicillin capsules (0.25 g) developed and produced by Hunan Anbang Pharmaceutical Co., Ltd. after single fasting and postprandial oral administration; using amoxicillin capsules (Sawacillin®, 250 mg) produced by LTL Pharmaceutical Co., Ltd. as the reference preparation, the pharmacokinetic parameters Cmax, AUC0-t, and AUC0-∞ of the two preparations were compared, and the bioequivalence of the two preparations in humans was evaluated.

Start Date-

Sponsor / Collaborator

Hunan Anbang Pharmaceuticals Co. Ltd.

100 Clinical Results associated with Uterine inflammation

100 Translational Medicine associated with Uterine inflammation

0 Patents (Medical) associated with Uterine inflammation

418

Literatures (Medical) associated with Uterine inflammation

01 Aug 2025·Tissue and Cell

Yi-Qi-Qing-Shi-Hua-Yu method improves uterine inflammation in rats with sequelae of pelvic inflammatory disease through the TLR4/NF-κB signaling pathway and regulates intestinal flora

Article

Author: Li, Maoya ; Wang, Yan ; Huang, Li ; Yin, Xiaolan ; Yang, Chengcheng ; Zhang, Enfeng

Sequelae of pelvic inflammatory disease (SPID) is a common gynecological disease, which is often accompanied by pathological changes and inflammation, and may even lead to infertility. The Yi-Qi-Qing-Shi-Hua-Yu method (YQQSHY), as a traditional Chinese medicine treatment method, is considered to have potential therapeutic effects on SPID. This study will explore the efficacy and potential mechanism of YQQSHY on SPID. This study established a SPID rat model by mixed bacteria and evaluated the regulatory effect of YQQSHY on uterine tissue pathology, immune status, and intestinal flora in SPID rats through histopathology, molecular experiments, immunology, and intestinal flora sequencing analysis. H&E staining showed that YQQSHY significantly reduced the pathological changes and fibrosis in the uterine tissue of SPID rats. ELISA results showed that YQQSHY could significantly reduce the levels of pro-inflammatory cytokines in the serum and vaginal secretions of SPID rats and increase the expression of anti-inflammatory factors. Flow cytometry analysis showed that the YQQSHY treatment group significantly adjusted the proportion of T cells in the peripheral blood of SPID rats. Western blot showed that YQQSHY can regulate TLR4, MyD88, p-NF-KB p65, and induce the transcription of p65 into the nucleus. Immunofluorescence examination of T cell subsets in uterine tissue. In addition, intestinal flora sequencing results showed that YQQSHY significantly modulated the composition and diversity of the intestinal flora of SPID rats. In conclusion, YQQSHY inhibits inflammatory response, regulates T cell ratio, and improves intestinal flora structure through the TLR4/NF-κB signaling pathway, which is the main mechanism for improving uterine inflammation and fibrosis in SPID rats. These findings provide experimental basis and theoretical support for further exploring the application of YQQSHY in clinical treatment.

01 Jun 2025·Journal of Reproductive Immunology

Chebulagic acid inhibits lipopolysaccharide-induced endometritis by regulating mitogen-activated protein kinase/nuclear factor-κB signaling

Article

Author: Yang, Ying ; Liu, Xinyu ; Gao, Ruifeng ; Gong, Zhiguo ; Zhao, Feifan ; Dong, Jinzhong ; Li, Zhengyi ; Zhang, Lanxin ; Zhang, Jianbing

This study investigates the potential protective effects of chebulagic acid (CA) against endometritis and its underlying molecular mechanisms. Network pharmacology analysis identified 19 potential targets of CA related to endometritis, mainly associated with the mitogen-activated protein kinase (MAPK) signaling pathways. Molecular docking analysis further indicated that MAPK14 and MAPK3 are critical targets of CA, suggesting its potential role in modulating inflammatory responses. In vitro experiments demonstrated that CA at concentrations of 12.5, 25, and 50 µg/mL significantly inhibited the secretion of proinflammatory cytokines interleukin (IL)-1β and IL-6 in lipopolysaccharide (LPS)-stimulated bovine endometrial epithelial cells (bEECs), without affecting cell viability. In vivo, CA treatment mitigated uterine inflammation in an LPS-induced mouse model of endometritis by downregulating high-mobility group box protein 1 (HMGB1) expression and inhibiting the phosphorylation of key signaling molecules, including p65, extracellular signal-regulated kinase (ERK), and p38. These findings suggest that CA exerts significant anti-inflammatory effects in endometritis by modulating the MAPK/NF-κB signaling pathway. Given its potential to suppress excessive inflammatory responses, CA may serve as a promising candidate for the development of novel therapeutic strategies for endometritis.

01 Jun 2025·Journal of Equine Veterinary Science

Effects of seminal plasma on uterine polymorphonuclear dynamics and fertility of jennies inseminated with glycerol-free, frozen-thawed donkey semen

Article

Author: Salinas, Elizabeth Morales ; Boeta, Myriam ; Vargas, Jeimmy Hernández ; Zarco, Luis ; Urías-Castro, Cristian

BACKGROUNDInsemination of jennies with frozen-thawed donkey semen usually causes an intense uterine inflammation and results in low fertility.OBJECTIVESTo evaluate the effects of seminal plasma on the time course of endometrial inflammation after insemination of jennies with donkey semen that was frozen using formamides as cryoprotective agents.METHODSJennies were inseminated with fresh semen (FS, n = 14), frozen-thawed semen (FTS, n = 12) or frozen-thawed semen plus seminal plasma (FTS-SP, n = 13), and uterine cytology was evaluated at 8, 24 and 48 h post-insemination.RESULTSAt 8 h post-insemination the percentage of polymorphonuclear cells (%PMN) was higher (P < 0.05) in the FTS group (90.7 ± 4.6) than in the FS group (68.9 ± 4.3), while jennies in the FTS-SP had intermediate levels (82.7 ± 4.5). At 24 h the %PMN was higher (P < 0.05) in jennies in the FTS-SP group (84.8 ± 4.5) than in the other groups. However, a faster decline in %PMN from 24 h to 48 h post-insemination in the FTS-SP group resulted in no difference between groups at 48 h. All groups still had mean %PMNs above 50 % at 48 h post-insemination, but the females that became pregnant had faster clearance rates from 24 h to 48 h post-insemination, resulting in lower %PMNs (44.4 ± 3.8) than those in the non-pregnant jennies (64.8 ± 3.6) at 48 h post-insemination (P<0.05).CONCLUSIONSeminal plasma induced faster uterine polymorphonuclear clearance after 24 h post-insemination in jennies inseminated with frozen-thawed donkey semen, and this effect could be related to improved fertility.

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Uterine inflammation

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