Anaplasia

Last update 08 May 2025

Basic Info

Synonyms

Anaplasia, Anaplasias, Anaplastic Change

+ [12]

Introduction

Loss of structural differentiation and useful function of neoplastic cells.

Clinical Trials associated with Anaplasia

NCT03823846

/ Unknown statusNot ApplicableIIT

The Effect of Doctor-nurse-patient Cooperative Analgesic Linkage Program on Movement Evoked Pain After Laparotomy for Patients With Hepatobiliary and Pancreatic Disease

To establish doctor-nurse-patient cooperative analgesic linkage program.
Evaluate the effect of doctor-nurse-patient cooperative analgesic linkage program on movement evoked pain after laparotomy for patients with hepatobiliary and pancreatic disease through quasi-experimental study.

Start Date01 Nov 2017

Sponsor / Collaborator

Second Affiliated Hospital Zhejiang University College of

100 Clinical Results associated with Anaplasia

100 Translational Medicine associated with Anaplasia

0 Patents (Medical) associated with Anaplasia

1,337

Literatures (Medical) associated with Anaplasia

01 Apr 2025·Ear, Nose & Throat Journal

Anaplastic Transformation in Papillary Thyroid Carcinoma: A Case Report

Article

Author: Hong, Ran ; Lyu, Young Sang ; Oh, Jeonghyun

Anaplastic thyroid cancer (ATC), a rare thyroid malignancy, accounts for only 5% of all thyroid cancers. However, it is the most aggressive form and has a very poor prognosis. Increasing evidence suggests that ATC arises from papillary thyroid carcinoma (PTC). However, the exact mechanism underlying this transformation remains unclear. In almost all cases, ATC originates within, but rarely outside, the thyroid gland. Transformation of metastatic PTC into ATC within the cervical lymph nodes is extremely rare. In this report, we present a rare case in a 63-year-old male patient who was initially diagnosed with PTC at his first hospital visit, which underwent anaplastic transformation in lymph node metastasis, and was subsequently diagnosed during the follow-up visit.

01 Jan 2025·Virchows Archiv

Rhabdomyosarcoma in children and young adults

Review

Author: Rudzinski, Erin R ; Kelsey, Anna M ; Chen, Sonja

Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood, accounting for 3% of all pediatric malignancies and 50% of all pediatric soft tissue sarcomas. In adolescents and young adults (AYA) however, RMS comprises only 6.5% of all soft tissue sarcomas. Historically, diagnosis and treatment of RMS was based on histologic recognition of the alveolar subtype, which was associated with a worse prognosis. Within the past 20 years, the biologic characteristics of RMS have become clearer, with canonical fusion drivers, PAX3/7::FOXO1, characterizing the alveolar subtype (ARMS) and in turn associated with poor outcome, while chromosomal gains/losses in addition to RAS pathway alterations characterize the embryonal subtype (ERMS). Accordingly, detection of a FOXO1 gene fusion has become a commonplace diagnostic and prognostic tool allowing tumors to be treated based on presence or absence of a FOXO1 gene fusion. However, these cytogenetic and molecular alterations represent only a portion of the molecular landscape found in RMS, and other alterations are found with increasing frequency in various subsets of RMS. Clinical trials basing risk stratification on the presence or absence of the canonical PAX3/7::FOXO1 fusions have had success in identifying the poor responders. Due to poor outcomes, the presence of MYOD1 and TP53 alterations which are common in spindle cell sclerosing RMS (SSRMS) and RMS with anaplasia have also been integrated into trial risk stratification. Therefore, complete histologic and immunophenotypic characterization remain important to better recognize and study these rare subsets of RMS. This article will discuss the challenges of RMS classification including how to combine morphologic, immunophenotypic and molecular data to arrive at an integrated diagnosis. The use of newer techniques such as liquid biopsy and methylation profiling, will also continue to shape the classification of RMS and may further refine risk stratification and prognosis.

01 Dec 2024·International Journal of Surgery Case Reports

Intracranial solitary fibrous tumour with rhabdomyosarcomatous differentiation: A diagnostic challenge of a rare presentation

Article

Author: Teckchandani, Vyomika ; Chohan, Shikhar ; Zaheer, Sufian

INTRODUCTION AND IMPORTANCESolitary fibrous tumors (SFTs) are rare mesenchymal neoplasms, initially described in the pleura but capable of arising in various anatomical locations, including the central nervous system. Dedifferentiation, characterized by the transformation of a low-grade tumor into a high-grade sarcoma, is an uncommon phenomenon in SFTs, especially in the intracranial region.CASE PRESENTATIONA 31-year-old male visited the neurology outpatient department with complaints of frequent headaches, seizures, speech difficulties, and weakness on the left side of his body. MRI was done which showed a relatively well defined T1 isointense and T2 hypointense extra-axial mass lesion in the right frontal lobe. Histopathological analysis confirmed the diagnosis of dedifferentiated SFT, marked by distinct fibroblastic differentiation and areas of high-grade sarcomatous transformation (rhabdomyosarcoma). Immunohistochemically, areas with fibroblastic differentiation showed strong and diffuse positivity for CD99, STAT6, vimentin and focal BCL-2 High-grade sarcomatous area was positive for vimentin, desmin and Myo-D1 and was negative for GFAP, EMA, PR, S-100, SMA and CD-34. It also showed focal positivity for STAT-6. The final diagnosis of intracranial solitary fibrous tumor with rhabdomyosarcomatous differentiation was made. At 2 months of follow-up, the patient is doing well.CLINICAL DISCUSSIONGiven the rarity of dedifferentiation in intracranial SFTs, there is limited consensus on optimal management strategies. En bloc resection remains the primary treatment approach, though the unpredictable behaviour of dedifferentiated SFTs complicates prognosis. This case underscores the importance of integrating clinical, radiological, and pathological findings for accurate diagnosis and discusses the need for further research into effective therapeutic options for dedifferentiated SFTs, particularly in challenging intracranial cases.CONCLUSIONThis case report presents a unique instance of an intracranial dedifferentiated SFT with rhabdomyosarcomatous dedifferentiation, highlighting the significant diagnostic challenges posed by this rare entity.

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