Request Demo

Last update 08 May 2025

Genital hemorrhage

Last update 08 May 2025

Basic Info

Synonyms

Bleeding genital, Genital bleeding, Genital haemorrhage

+ [10]

Introduction-

Clinical Trials associated with Genital hemorrhage

CTR20240436

/ CompletedNot Applicable

氨甲环酸片人体生物等效性试验

[Translation] Bioequivalence study of tranexamic acid tablets in human subjects

采用单中心、随机、开放、两周期、两序列、双交叉、单剂量口服试验设计比较空腹和餐后给药条件下，江苏知原药业股份有限公司提供的氨甲环酸片（250 mg）与DAIICHI SANKYO CO., LTD.（第一三共株式会社）持证的氨甲环酸片（商品名：Transamin®；规格：250 mg）在中国健康人群吸收程度和吸收速度的差异，并评价江苏知原药业股份有限公司提供的氨甲环酸片的安全性。

[Translation]

A single-center, randomized, open, two-period, two-sequence, double-crossover, single-dose oral trial was conducted to compare the differences in the extent and rate of absorption of tranexamic acid tablets (250 mg) provided by Jiangsu Zhiyuan Pharmaceutical Co., Ltd. and tranexamic acid tablets (trade name: Transamin®; specification: 250 mg) certified by DAIICHI SANKYO CO., LTD. in healthy Chinese people under fasting and postprandial administration conditions, and to evaluate the safety of tranexamic acid tablets provided by Jiangsu Zhiyuan Pharmaceutical Co., Ltd.

Start Date12 Mar 2024

Sponsor / Collaborator

Sinomune Pharmaceutical Co., Ltd.

CTR20234332

/ CompletedNot Applicable

氨甲环酸片人体生物等效性研究

[Translation] Study on the bioequivalence of tranexamic acid tablets in healthy volunteers

主要目的：比较空腹及餐后给药条件下，北京北陆药业股份有限公司提供的氨甲环酸片（规格：0.5 g）与DAIICHI SANKYO CO., LTD.（第一三共株式会社）持证CMIC CMO CO.,LTD.Shizuoka Plant生产的氨甲环酸片（商品名：妥塞敏®/Transamin®；规格：0.5 g）在健康人群中吸收程度和速度的差异。次要目的：评价空腹及餐后给药条件下，北京北陆药业股份有限公司提供的氨甲环酸片（规格：0.5 g）与DAIICHI SANKYO CO., LTD.（第一三共株式会社）持证CMIC CMO CO.,LTD.Shizuoka Plant生产的氨甲环酸片（商品名：妥塞敏®/Transamin®；规格：0.5 g）的安全性。

[Translation]

Primary objective: To compare the differences in absorption degree and speed of tranexamic acid tablets (specification: 0.5 g) provided by Beijing Beilu Pharmaceutical Co., Ltd. and tranexamic acid tablets (trade name: Tosamine®/Transamin®; specification: 0.5 g) produced by CMIC CMO CO.,LTD.Shizuoka Plant of DAIICHI SANKYO CO., LTD. under fasting and postprandial administration in healthy people. Secondary objective: To evaluate the safety of tranexamic acid tablets (specification: 0.5 g) provided by Beijing Beilu Pharmaceutical Co., Ltd. and tranexamic acid tablets (trade name: Tosamine®/Transamin®; specification: 0.5 g) produced by CMIC CMO CO.,LTD.Shizuoka Plant of DAIICHI SANKYO CO., LTD. under fasting and postprandial administration.

Start Date14 Jan 2024

Sponsor / Collaborator

Beijing Beilu Pharmaceutical Co., Ltd.

CTR20240119

/ CompletedNot Applicable

氨甲环酸片人体生物等效性研究

[Translation] Study on the bioequivalence of tranexamic acid tablets in healthy volunteers

本试验旨在研究单次空腹和餐后口服杭州康恩贝制药有限公司研制、生产的氨甲环酸片（250 mg）的药代动力学特征；以第一三共株式会社生产的氨甲环酸片（Transamin®，250 mg）为参比制剂，比较两制剂中药动学参数Cmax、AUC0-t、AUC0-∞，评价两制剂的人体生物等效性。

[Translation]

This study aimed to investigate the pharmacokinetic characteristics of tranexamic acid tablets (250 mg) developed and produced by Hangzhou Kangenbei Pharmaceutical Co., Ltd. after single oral administration on an empty stomach or after a meal; using tranexamic acid tablets (Transamin®, 250 mg) produced by Daiichi Sankyo Co., Ltd. as the reference preparation, to compare the pharmacokinetic parameters Cmax, AUC0-t, and AUC0-∞ of the two preparations, and to evaluate the bioequivalence of the two preparations in humans.

Start Date13 Jan 2024

Sponsor / Collaborator

Hangzhou CONBA Pharmaceutical Co. Ltd.

100 Clinical Results associated with Genital hemorrhage

100 Translational Medicine associated with Genital hemorrhage

0 Patents (Medical) associated with Genital hemorrhage

783

Literatures (Medical) associated with Genital hemorrhage

01 Jun 2025·Archivos Argentinos de Pediatria

Peripheral precocious puberty secondary to severe hypothyroidism

Article

Author: Besseghine, Gonzalo ; Freire, Analía ; Rodríguez, María E ; Rojas, Sonia ; Martino, Florencia ; Rojas Ortiz, María V ; Arcari, Andrea ; Gil, Melina

Van Wyk-Grumbach syndrome is a rare form of severe hypothyroidism. We present a 10.9-year-old girl who consulted for genital bleeding, Tanner stage 2, and clinical manifestations of hypothyroidism. Severe hypothyroidism was confirmed, secondary to chronic lymphocytic thyroiditis. A pelvic ultrasound showed bilateral evidence of cystic ovarian masses. The hormonal profile confirmed peripheral precocious puberty secondary to hypothyroidism. A pituitary MRI showed significant pituitary elongation due to thyrotropic hyperplasia. After initiating treatment with thyroid hormone, there was a notable clinical improvement and resolution of the adnexal masses and pituitary hyperplasia. The pediatrician must be able to identify signs and symptoms associated with thyroid dysfunction and prompt referral to a pediatric endocrinologist to avoid the appearance of severe conditions such as the one presented.

01 May 2025·Archives of Disease in Childhood

Genital bleeding in prepubertal girls: a systematic review

Review

Author: Gabriel, Lily ; Hopkinshaw, Bryony ; Moore, Yasmin ; Arrowsmith, Briony ; White, Catherine

IntroductionThis systematic review aims to collate evidence of the causes of genital bleeding, other than child sexual abuse and accidental injuries, presenting in prepubertal girls. It provides an update to the 2015 Royal College of Paediatrics and Child Health publication ‘The Physical Signs of Child Sexual Abuse’, an evidence-based review also known as the Purple Book.MethodsMEDLINE, EMBASE and Scopus databases were searched for studies published between March 2014 and June 2023. Eligible studies were primary studies reporting on genital bleeding with extractable data for prepubertal girls.Results99 studies, describing a total of 672 prepubertal girls, met the inclusion criteria. The most common medical conditions with genital bleeding as a presenting feature were lichen sclerosus, infections and infestations, hormonal causes, urethral prolapse, vaginal foreign bodies and tumours. Meta-analysis was not possible due to the large heterogeneity of the studies.ConclusionThis review added further evidence to the 2015 edition of the Purple Book, describing the multiple medical conditions that may present with genital bleeding. Several of these conditions can mimic the presentation of child sexual abuse or may coexist with child sexual abuse.

01 Mar 2025·International Journal of Surgery Case Reports

Benckiser's hemorrhage: An uncommon cause of genital hemorrhage occurring in the third trimester - A case report

Article

Author: Mouiman, Soukaina ; Essebbagh, Youssef ; Zeraidi, Najia ; Baidada, Aziz ; Errmili, Khadija ; Lakhder, Amina

INTRODUCTIONBenckiser's hemorrhage is a rare obstetric emergency characterized by massive genital hemorrhage during the third trimester. This condition necessitates urgent fetal extraction. Prenatal diagnosis is not routinely recommended. This article reports a case where vasa previa was diagnosed antenatally, but the pregnancy outcome was unfavorable.CASE REPORTA 32-year-old woman, G3P1, presented at 32 weeks gestation with pelvic pain resembling uterine contractions. A transvaginal ultrasound revealed a suspected vascular anomaly near the internal cervical os. However, at 35 WG, she returned with cervical dilation, ruptured membranes, and profuse bleeding without maternal complications, prompting an emergency cesarean. The newborn, a male, had Apgar scores of 2/3/3 and was resuscitated with a blood transfusion.DISCUSSIONBenckiser's hemorrhage is a life-threatening event for the fetus, leading to fetal death in most cases due to acute exsanguination. Vasa previa occurs when abnormal blood vessels traverse the membranes between the fetus and the cervix. While routine screening for vasa previa is not recommended, prenatal diagnosis is crucial in the presence of risk factors. Ultrasound and Doppler are essential for diagnosing vasa previa. The prognosis for the newborn improves if vasa previa is diagnosed before labor. However, when diagnosed during labor, the prognosis remains poor. Cesarean section is recommended between 34 and 36 WG.CONCLUSIONWhile routine screening for vasa previa is not standard practice, it is recommended in cases with identified risk factors. Early detection, increased prenatal monitoring, and planned cesarean delivery can reduce mortality associated with Benckiser's hemorrhage.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Genital hemorrhage

Basic Info

Related

Analysis