Ichthyosis Prematurity Syndrome

CAMBRIDGE, Mass.--(BUSINESS WIRE)-- Incendia Therapeutics, a precision oncology company discovering and developing a novel class of therapies that reprogram the tumor microenvironment (TME), today announced that it will present data in collaboration with PathAI, a leading AI-powered precision pathology company at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place May 31 – June 4, 2024 in Chicago, Illinois. “I am delighted to be sharing more from our exciting collaboration with PathAI in a poster session at ASCO, highlighting the potential of utilizing digital pathology-based biomarkers to predict outcome in a clinical setting,” said Laura Dillon, PhD, Vice President of Translational Medicine & Bioinformatics at Incendia Therapeutics. “The data demonstrate the correlation between immune phenotypes predicted from hematoxylin and eosin (H&E)-stained whole slide images and survival following checkpoint inhibitor therapy in non-small cell lung cancer (NSCLC). We believe these data support the possibility of improving patient outcomes in NSCLC by advancing the identification of PD-L1(-) patients who may derive greater benefit from treatment with check-point inhibitors.” Presentation details for ASCO 2024 are as follows: Title: Correlation of immune phenotypes derived from H&E-stained whole slide images with prognosis and response to checkpoint inhibitors in NSCLC Abstract Number: 8539 Presenting Authors: Bahar Rahsepar, Senior AI Product Manager at PathAI, Inc. and Laura Dillon, Ph.D., Vice President of Translational Medicine & Bioinformatics at Incendia Therapeutics Poster Session: Lung Cancer—Non-Small Cell Metastatic Date and Time: Monday, June 3 from 1:30 - 4:30 PM CDT (2:30 – 5:30 PM EDT) Key Highlights: The classification of tumors as inflamed, excluded or desert based on spatial patterns of tumor infiltrating lymphocytes (TILs) is a potential biomarker of patients likely to respond to checkpoint inhibitors (CPI). However, the subjectivity of manual methods to assess these immune phenotypes (IPs) and poor standardization in the methods and thresholds to define IPs have hampered their clinical adoption. Using a data-driven approach for predicting IPs using patch-level TIL features, AI model-predicted IPs were prognostic in The Cancer Genome Atlas (TCGA) NSCLC dataset and predictive of progression free survival (PFS) in a CPI- treated clinical NSCLC cohort. Association of IP and PFS was independent of PD-L1 status, potentially allowing the identification of PD-L1(-) patients who may derive greater benefit from CPI. In The Cancer Genome Atlas (TCGA) NSCLC cohort, model-predicted inflamed immune phenotypes (IP) (iIP) (N=196) and excluded IP (eIP) (N=607) patients had significantly better overall survival (OS) compared to desert IP (dIP) (N=80; HR=0.53, p=0.003 and HR=0.59, p=0.003, respectively). In the clinical cohort, cancer tumor infiltrating lymphocytes density and fraction of hot epithelial patches were significantly associated with (PFS) (HR=0.64, q=0.04 and HR=0.69, q=0.04, respectively). PFS was significantly shorter in model-predicted eIP patients (N=46) compared to iIP (N=39; HR=0.54, p=0.045). Notably, in PD-L1(-) patients (N=43, tumor proportion score ≤1%), iIP patients had longer PFS than eIP and dIP patients (HR=0.35, p=0.02). No difference in PFS was observed for PD-L1(+) patients. About Incendia Therapeutics Incendia Therapeutics is discovering and developing a novel class of experimental therapeutics that reprogram the tumor microenvironment (TME). Incendia’s platform is based on rigorous, groundbreaking research involving spatial characterization of the tumor microenvironment, multi-omics data integration, and extensive preclinical testing. The Company’s most advanced experimental molecule, PRTH-101, is in a Phase 1 clinical trial for the treatment of patients with advanced solid tumors. For more information visit incendia.com and LinkedIn.

Researchers investigate the influence of social relationships on our bodily responses to the presence of other persons in the interpersonal space. Most studies on interpersonal space (IPS) focus on the physiological and psychological responses to the presence of strangers in IPS. However, having a social relation with a person or their relative position in the IPS can influence these responses. Recently, researchers investigated the responses to the presence of friends and acquaintances at different relative positions in IPS, measuring the changes in discomfort, heart rate, and parasympathetic activity. Overall, this study enhances our understanding of IPS. When we communicate with other people face-to-face, we do so by maintaining a certain physical distance from each other. This space surrounding our body while interacting is called the interpersonal space (IPS), and maintaining adequate IPS is crucial for better communication. Many studies have investigated the psychological and physiological changes that occur based on the presence of another person in the IPS during face-to-face interactions. These studies are based on the avoidance behaviour that we experience when a stranger invades our IPS, which manifests in the form of increased heart rate and discomfort. However, having a social relation with a person, such as with a friend or a spouse, can influence this behaviour. Moreover, most studies have only examined IPS in front of or behind a person, using tasks such as a stopping task, wherein a stranger approaches or retreats from the IPS. They have not determined the shape of IPS by considering different relative positions around a person. Addressing this gap, a team of researchers from Japan, led by Assistant Professor Kae Mukai from the Faculty of Science and Engineering at Waseda University, investigated the effect of social relationships on the physiological and psychological responses to the presence of another person in the IPS. Dr. Mukai explains, "Considering a real-life situation in which acquaintances or friends are standing next to us, the threat level might be relatively low compared to when strangers are standing next to us. Given the evidence, that smaller IPSs may be formed with family and friends, psychological and physiological responses can differ. In this study, we uncovered these differences." The team also included Dr. Tomoko Isomura from Nagoya University and Dr. Ryoji Onagawa and Professor Katsumi Watanabe from Waseda University. Their findings were published in the journal Scientific Reports on February 21, 2024. The researchers used electrocardiogram (ECG) data to measure the changes in subjective discomfort, heart rate, and heart rate variability (HRV), which indicates parasympathetic activity or the "rest and digest" nervous response, of a person due to the presence of another person at various relative positions in the IPS. They measured these changes during two tasks. In the first task, participants were paired with their friends in a static standing task, where a person stood 30 cm away from the other, with both hands behind their back, within the IPS for a minute. There were eight relative positions in all: F-see, L-see, R-see, and B-see, as well as F-seen, L-seen, R-seen, and baseline. In the first case, participants stood face-to-face with their friend and looked at the center of their eyes. In the next three cases, they looked at their friend's left profile, right profile, and back, respectively, with their eyes fixed on the head. On the other hand, the participants stood with their eyes fixed on the fixation point 30 cm in front of them while being seen at their left pro right pro and backs by their friend in F-seen, L-seen, and R-seen conditions, respectively. Lastly, in the baseline condition, both persons were standing back-to-back, unable to see each other. In the second task, a cylindrical object with height same as that of the person was placed at different positions in the IPS. The experiments revealed that the greatest discomfort, the greatest decrease in heart rate, and the greatest increase in HRV occurred in the F-see condition. The researchers attributed the decrease in heart rate and increase in parasympathetic activity to the presence of familiar people, as previous studies have shown that the presence of a friend or romantic partner activates parasympathetic activity. Moreover, they found that heart rate only decreased in relative positions F-see and R-see. Additionally, no changes were observed during the task with the object. These findings are inconsistent with previous studies which report that sympathetic activity, or the "fight or flight" response, is activated when a stranger invades our personal space. "Our study suggests that social relationships between two people influence our physiological responses during social interactions," says Dr. Mukai. "Our findings could help in the development of a society that makes life easier for a diverse range of people, by introducing appropriate communication methods that vary according to changes in responses to the presence of others."