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Last update 08 May 2025

Abortion, Incomplete

Last update 08 May 2025

Basic Info

Synonyms

Abortion spontaneous incomplete, Abortion spontaneous incomplete NOS, Abortion, Incomplete

+ [25]

Introduction

Premature loss of PREGNANCY in which not all the products of CONCEPTION have been expelled.

Clinical Trials associated with Abortion, Incomplete

ACTRN12624001463561

/ RecruitingPhase 4IIT

Comparison of misoprostol and conservative approach for managing first trimester retained products of conception and use of ultrasound to predict success– an open labelled randomized controlled trial

Start Date06 Feb 2025

Sponsor / Collaborator

Nepean Hospital

NCT06456164

/ Not yet recruitingNot ApplicableIIT

IntraCERvical Balloon Catheter in the Setting of Induction of Labor for Fetal Loss or Abortion (CERBI): a Pilot Randomized Controlled Trial

The goal of this research is to understand whether it is practical and safe to use an intracervical balloon catheter in addition to standard of care medications at the time of an induction of labor for an abortion or fetal death. The medical device used in this study is cleared by the Food and Drug Administration (FDA) and is used for induction of labor at term gestational ages (at or above 37 weeks of gestation). The study team will also collect data about patient-level experiences with the procedure, time in labor, and labor-related complications, such as higher-than-expected blood loss or infection.

Start Date01 Feb 2025

Sponsor / Collaborator

The University of Chicago

PACTR202409853980242

/ RecruitingEarly Phase 1IIT

Comparing 2%Lignocaine and 2%Lignocaine with Hyoscine Butylbromide in Pain Reduction During Manual Vacuum Aspiration For Incomplete Abortion in Juth

Start Date01 Jun 2024

Sponsor / Collaborator-

100 Clinical Results associated with Abortion, Incomplete

100 Translational Medicine associated with Abortion, Incomplete

0 Patents (Medical) associated with Abortion, Incomplete

849

Literatures (Medical) associated with Abortion, Incomplete

01 May 2025·Radiology Case Reports

An unsuspected case of uterine arteriovenous malformation with nidus aneurysm following vaginal delivery: Diagnostic challenges and management

Article

Author: Ps, Abhiram ; Chavadi, Chanabasappa V ; Nautiyal, Aakanksha

Uterine arteriovenous malformations (AVMs) are rare but potentially life-threatening cause of postpartum hemorrhage (PPH). Accurate differentiation from other PPH causes, such as retained products of conception (RPOC) and gestational trophoblastic disease (GTD), is imperative, as inadvertent improper management such as uterine curettage may cause catastrophic bleeding with high mortality rates. We present the case of 35-year-old woman who presented with excessive vaginal bleeding 2 months postnormal vaginal delivery. Initial ultrasound findings raised suspicion of uterine AVM with a differential diagnosis of type 3 RPOC. Further imaging with computed tomography angiography (CTA) and digital subtraction angiography (DSA) confirmed an underlying uterine AVM with a nidus aneurysm. The patient subsequently was treated with successful embolization and was discharged in stable condition.

01 Apr 2025·Contraception

Change in hCG levels after very early medication abortion for pregnancy of unknown location or probable intrauterine pregnancy

Article

Author: Cederblad, Kristina ; Kopp-Kallner, Helena ; Jar-Allah, Tagrid ; Heikinheimo, Oskari ; Gyllenberg, Frida ; Hognert, Helena ; Brandell, Karin ; Gemzell-Danielsson, Kristina ; Kaislasuo, Janina

OBJECTIVE(S)To evaluate changes in serum/plasma human chorionic gonadotropin (hCG) from baseline levels in very early medication abortion (VEMA) in pregnancies of unknown location (PUL) and probable intrauterine pregnancy (IUP) to confirm treatment success.STUDY DESIGNA prospective cohort was selected from the VEMA randomized controlled trial conducted at 26 sites across nine countries. Patients with a gestational age ≤42 days without confirmed IUP on ultrasound (n = 741) received medication abortion according to WHO guidelines, hCG was measured at mifepristone intake and repeated on day 7 (+/-2). Changes in hCG were analyzed to distinguish the trends associated with complete abortion versus ectopic pregnancy, ongoing pregnancy, and incomplete abortion.RESULTSAmong 533 cases with complete abortion, a decline in hCG level of ≥80% was observed in 96.8 of cases 7 (+/-2) days post-abortion. The mean hCG decline for complete abortions was 94% (CI: 93.2-94.9). None of the ectopic pregnancies 8 (1.7%) or ongoing pregnancies 21 (2.9%), showed a decline of ≥80%. Rising or insufficient decline (<80%) indicated ectopic and ongoing pregnancy. The hCG trend following complete abortion was significantly different from all other outcomes (p < 0.001), but trends did not distinguish between ectopic, ongoing pregnancy, or incomplete abortion.CONCLUSION(S)A hCG decline of ≥80% within 7 (+/-2) days can effectively confirm complete abortion and rule out ectopic and ongoing pregnancies in early medication abortion. These results highlight the effectiveness of hCG monitoring as a reliable follow-up tool for managing VEMA without confirmed IUP.

11 Mar 2025·Cureus

Characteristics and Diagnostic Accuracy of Retained Products of Conception After Delivery vs. Abortion: A Retrospective Cohort Study

Article

Author: Sgayer, Inshirah ; Kalendaryov, Alex ; Lowenstein, Lior ; Mustafa Mikhail, Susana ; Aiob, Ala ; Sharon, Avishalom

OBJECTIVEWe aimed to evaluate and compare the characteristics, clinical presentations, sonographic features, and hysteroscopic complications of retained products of conception (RPOC) after delivery versus abortion and to compare the accuracy of diagnosing RPOC in these two conditions.METHODOLOGYThis retrospective cohort study included 226 women aged 17-50 years who underwent hysteroscopy for suspected RPOC following spontaneous or induced abortion or delivery between 2018 and 2021. The diagnosis was based on a routine ultrasound, with a hysteroscopy conducted within one week. Collected data encompassed demographics, obstetric history, sonographic findings, clinical features, operative details, and pathology reports.RESULTSOf the 226 women included, 65 (28.8%) had RPOC post-delivery and 161 (71.2%) post-abortion. While age and parity did not differ significantly between the groups, gravidity was higher, and previous abortions were more common among the women post-abortion. Symptomatic presentation differed; bleeding and pain were more common post-delivery, and asymptomatic presentation was more frequent post-abortion. Sonographically, Doppler flow was more prevalent post-abortion. The optimal endometrial thickness cutoffs for predicting RPOC post-abortion and post-delivery were 1.55 and 1.49 cm, respectively.CONCLUSIONSOur study found significant differences in clinical and sonographic characteristics between women with RPOC after abortion versus delivery, emphasizing the importance of tailored diagnostic and management strategies. Although detection rates and sonographic findings varied, routine sonographic assessment is crucial, especially post-abortion. Endometrial thickness proved a reliable predictor for RPOC in both groups.

News (Medical) associated with Abortion, Incomplete

06 Nov 2024

·www.drugs.com

Medication Abortion Before Confirmed Intrauterine Pregnancy Noninferior

WEDNESDAY, Nov. 6, 2024 -- For complete abortion , medication abortion before confirmed intrauterine pregnancy is noninferior to standard, delayed treatment, according to a study published in the Nov. 7 issue of the New England Journal of Medicine . Karin Brandell, M.D., from the Karolinska Institutet in Stockholm, and colleagues conducted a multicenter, noninferiority, randomized controlled trial involving women requesting medication abortion at up to 42 days of gestation with an unconfirmed intrauterine pregnancy on ultrasound examination. Participants were randomly assigned to immediate start of abortion (early-start group; 754 participants) or standard-care treatment delayed until intrauterine pregnancy was confirmed (standard-care group; 750 participants). For the absolute between-group difference, the noninferiority margin was set at 3.0 percentage points. The researchers found that a complete abortion occurred in 95.2 and 95.3 percent of participants in the early-start and standard groups, respectively (absolute between-group difference, −0.1 percentage points). Ectopic pregnancies occurred in 1.3 and 0.8 percent of participants in the early-start and standard-care groups, respectively. Serious adverse events occurred in 1.6 and 0.7 percent of participants in the early-start and standard groups, respectively, most of which were uncomplicated hospitalizations for ectopic pregnancy or incomplete abortion. "We found that early start of medication abortion before confirmed intrauterine pregnancy was noninferior to delayed treatment after confirmed intrauterine pregnancy with respect to completing abortion," the authors write.

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