Acute Fatty Liver of Pregnancy

Last update 08 May 2025

Basic Info

Synonyms

AFLP, AFLP (acute fatty liver of pregnancy), AFLP - Acute fatty liver of pregnancy

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Introduction

Acute fatty liver of pregnancy is a rare but severe complication occurring in the third trimester of pregnancy or in early postpartum period bearing a risk for perinatal and maternal mortality with manifestations of jaundice, rise of hepatic injuries and evolving to acute liver failure and encephalopathy.

Clinical Trials associated with Acute Fatty Liver of Pregnancy

NCT03834285

/ RecruitingNot ApplicableIIT

EASL: European Registry of Liver Disease in Pregnancy

Liver Diseases in pregnancy represents rare disorders and current data is derived primarily from single centres and retrospective cohorts. Moreover, the population prevalence of these diseases is low and to-date, it has proven difficult to generate reliable data at a patient level.
This is a multi-center, prospective cohort study that will open at 3 centers within the UK; and 4 centers in the European Union. The investigators will aim to collect data and blood samples at various time points, for patients presenting with liver disease during pregnancy. The main rationale behind this study is to establish a platform that enables detailed review of the outcomes of these rare diseases; to help classify and stratify patients according to risk and develop interventional studies and care pathways to improve overall outcome.

Start Date09 May 2019

Sponsor / Collaborator

King's College Hospital NHS Foundation Trust

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100 Clinical Results associated with Acute Fatty Liver of Pregnancy

100 Translational Medicine associated with Acute Fatty Liver of Pregnancy

0 Patents (Medical) associated with Acute Fatty Liver of Pregnancy

389

Literatures (Medical) associated with Acute Fatty Liver of Pregnancy

01 Feb 2025·Journal of Obstetrics and Gynaecology Research

Acute fatty liver of pregnancy may be associated with non‐productive coagulopathy of coagulation and fibrinolytic factors as well as disseminated intravascular coagulation with mild or no thrombocytopenia: Review of case reports in Japan

Review

Author: Horie, Kenji ; Fujiwara, Hiroyuki ; Usui, Rie ; Suzuki, Hirotada ; Ogoyama, Manabu ; Ohkuchi, Akihide ; Takahashi, Hironori

AbstractAimWe reviewed case reports of acute fatty liver of pregnancy (AFLP) in Japan and summarized its characteristics, including coagulation factors, fibrinolytic factors, and platelet counts.MethodsPubMed/Medline and Ichushi databases from 2000 to 2022 were used to survey articles related to AFLP, and 93 articles (102 patients) were ultimately identified.ResultsThe characteristics of the coagulation and fibrinolysis systems in AFLP were as follows: the prothrombin time‐international normalized ratio and activated partial prothrombin time were prolonged (median value [quartiles]: 1.59 [1.31, 2.02] and 47.5 s [28.2, 97.5], respectively), and antithrombin and alpha 2‐antiplasmin levels were low (23.0% [17.0, 33.0] and 44.6%, respectively), indicating non‐productive coagulopathy due to severe liver damage. The concentrations of the thrombin‐antithrombin complex and fibrinogen/fibrin degradation products were high (60.0 ng/mL [49.1, 82.8] and 49.2 μg/mL [20.8, 143.7], respectively), while the level of fibrinogen was low (82.0 mg/dL [52.5, 153.5]), suggesting disseminated intravascular coagulation with increased coagulation activity. A platelet count ≥12 × 104/μL was detected in approximately 70% of AFLP cases, and the median was within the normal range (16.1 × 104/μL [11.1, 19.2]).ConclusionsCoagulopathy changes in AFLP may be based on non‐productive coagulopathy of coagulation and fibrinolytic factors as well as disseminated intravascular coagulation with mild or no thrombocytopenia.

01 Jan 2025·Clinical Medicine

Acute confusion in pregnancy

Review

Author: Hill, Amanda ; Neuberger, Francesca

If a woman is acutely confused in pregnancy, she will most likely present to an unscheduled care setting outside of maternity services. It is therefore essential that all clinicians working within general medicine are comfortable assessing pregnant women in this context. Useful resources are available to support assessing pregnant women who present acutely; however, confusion is beyond their scope. This article discusses important aspects to consider when assessing pregnant women and places emphasis on a systematic approach to ensure that obstetric and non-obstetric causes of confusion have been considered. Certain life-threatening diagnoses have been further discussed in more detail (Wernicke's encephalopathy, hyponatraemia, hypercalcaemia, acute fatty liver of pregnancy and thrombotic thrombocytopenia purpura). These conditions have been chosen as there is a significant risk of maternal mortality and morbidity as well as poor fetal outcomes if not recognised and treated early.

30 Dec 2024·Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

[Acute fatty liver of pregnancy with severe coagulopathy: a case report and review].

Review

Author: Cui, L ; Cao, R Y ; Meng, H B ; Cai, L Y ; Zhang, X ; Meng, X L

Acute fatty liver in pregnancy (Acute fatty liver of pregnancy, AFLP) in pregnancy is a relatively rare critical condition in obstetrics, which is difficult to distinguish in the early stages due to the non-specificity of its clinical manifestations. However, early recognition and timely termination of pregnancy is significant for the treatment of AFLP and is crucial to reduce mortality.This paper will report in detail a patient with AFLP at 37 weeks' gestation, mainly presenting with nausea and vomiting for 1 week and yellow skin for 2 days.Due to the relatively long course of the disease, the patient suffered a regrettable result of fetal death after emergency admission, and severe coagulation dysfunction, pulmonary edema, and pancreatitis occurred.The multidisciplinary team from the department of anesthesiology, ICU, hematology, blood transfusion department and so on, actively corrected coagulation disorders and multiple organ injuries in the emergency termination of pregnancy, and the patient had a good prognosis.The importance of early identification for the treatment of AFLP patients can be demonstrated, and the changes of coagulation function can be closely monitored to guide clinical treatment.

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Acute Fatty Liver of Pregnancy

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