Leaky Gut

JEJU, South Korea, Nov. 11, 2024 /PRNewswire/ -- Professor Narayanan Parameswaran's team at the Department of Physiology at Michigan State University announced the results of a study that showed that consuming red ginseng is effective for bone and intestinal health through intestinal microbiota balance at the Korea Ginseng Society International Conference held from October 27 (Sun) to 30 (Wed). Continue Reading Professor Parameswaran of Michigan State University presents the results of research on red ginseng's intestinal and bone health at the Korea Ginseng Society International Conference Prior to this study, the Michigan State University research team reported in 2023 in the JGR (Journal of Ginseng Research, I.F 6.8) that intestinal microbiota balance is an important regulatory factor for bone health. After administering antibiotics to a mouse model for two weeks and observing for four weeks, it was confirmed that an imbalance in the composition of the intestinal microflora caused leaky gut syndrome (a condition in which the intestinal mucosal cells are damaged and the barrier is weakened, allowing various substances to pass through, causing symptoms such as gas, diarrhea, constipation, abdominal bloating, and indigestion) and bone loss. The research team administered red ginseng extract to a mouse model whose intestinal microflora balance was disrupted by antibiotics for four weeks and confirmed the effects of improving barrier function and bone density. As a result of the study, the experimental group that consumed red ginseng showed an increase in the diversity of beneficial intestinal bacteria and an improvement in barrier health, which reduced the symptoms of leaky gut syndrome. This suggests that improving the intestinal environment also had a positive effect on bone health. Professor Parameswaran said, "There have been previous research results showing that red ginseng and ginseng help with bone health, but this is the first to show that they help with the balance of intestinal microorganisms, thereby preventing bone loss and leaky gut syndrome." He added, "It is significant that we have confirmed the beneficial effect of red ginseng on gut-bone axis in multiple models of bone loss and the potential for red ginseng to be developed as a treatment for osteoporosis in the future." At this international academic conference of the Korea Ginseng Society held in Jeju Island, Korea, researchers from leading international universities and hospitals in the US, Korea, China, and Japan presented research results on a total of 30 topics, including inhibition of colon cancer cell growth effects of immunity against respiratory viruses improvement of endometriosis. Meanwhile, the Ministry of Food and Drug Safety of Korea recently officially recognized the functionality of red ginseng in helping control blood sugar levels. This has been scientifically proven through long-term clinical research by 'JungKwanJang', a global representative comprehensive health brand that has ranked first in the global ginseng retail market for 10 consecutive years. JungKwanJang confirmed that consuming red ginseng reduces not only fasting blood sugar but also postprandial blood sugar and glycated hemoglobin, and scientifically proved that it controls blood sugar through various indicators such as insulin resistance and glucose metabolism control through an increase in GLP-1 (a hormone involved in blood sugar control and appetite suppression). 'JungKwanJang' is the No. 1 red ginseng brand trusted worldwide based on long-standing tradition and strict quality control, and ranked first in the global 'herbal health supplement' retail market compiled by Euromonitor International, a global market research institute. In addition, it has established an R&D center in Fullerton, near LA, USA, beyond Korea, and is striving to develop products that meet the health needs and tastes of local Americans. the results of a study by Professor Narayanan Parameswaran's team at the Department of Physiology at Michigan State University - SOURCE The Korean Society of Ginseng WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Celiac disease is a chronic autoimmune condition that occurs in around one per cent of the world's population. It is triggered by the consumption of gluten proteins from wheat, barley, rye and some oats. A gluten-free diet protects celiac patients from severe intestinal damage. Today is International Celiac Day. Celiac disease is a chronic autoimmune condition that occurs in around one per cent of the world's population. It is triggered by the consumption of gluten proteins from wheat, barley, rye and some oats. A gluten-free diet protects celiac patients from severe intestinal damage. Together with colleagues, chemist Dr Veronica Dodero from Bielefeld University was able to determine new details on how certain gluten-derived molecules trigger leaky gut syndrome in celiac disease. The key finding of the study: a particular protein fragment formed in active celiac disease forms nanosized structures, the so-called oligomers, and accumulates in a gut epithelial cell model. The technical name of the molecule is 33-mer deamidated gliadin peptide (DGP). The study team has now discovered that the presence of DGP oligomers may open the tightly closed gut lining, leading to the leaky gut syndrome. The study has now been published in the journal 'Angewandte Chemie'. Wheat Peptides Causing Leaky Gut When we eat wheat, our bodies cannot completely break down gluten proteins. This can lead to the formation of large gluten fragments (peptides) in our gut. In cases of active coeliac disease, researchers discovered that the enzyme tissue transglutaminase 2 (tTG2) present in humans modifies a specific gluten peptide, resulting in the formation of the 33-mer DGP. This usually happens in a part of our gut called the lamina propria. However, recent research has shown that this process can also occur in the gut lining. 'Our interdisciplinary team characterized the formation of 33-mer DGP oligomers through high-resolution microscopy and biophysical techniques. We discovered the increased permeability in a gut cell model when DGP accumulates, reports Dr. Maria Georgina Herrera, the first author of the study. She is researcher at the University of Buenos Aires in Argentina and was a postdoctoral fellow at Bielefeld. When the intestinal barrier is weakened Leaky gut syndrome occurs when the lining of the intestine becomespermeable, allowing harmful substances to enter the bloodstream, leading to inflammatory responses and different diseases. In celiac disease, there's debate about the early stages of increased permeability. The mainstream theory suggests that chronic inflammation in coeliac disease leads to a leaky gut. However, there is a second theory that proposes that gluten's effects on gut lining cells are the primary cause. In this view, gluten directly damages the cells of the intestinal lining, making thempermeable, which triggers chronic inflammation and potentially leads to celiac disease in predisposed people. However, since gluten is consumed daily, what molecular triggers lead to the leaky gut in celiac disease patients? If 33-merDGP oligomers are formed, they may damage the epithelial cell network, allowing gluten peptides, bacteria, and other toxins to pass massively into the bloodstream, leading to inflammation and, in celiac disease, autoimmunity. 'Our findings reinforce the medical hypothesis that impairment of the epithelial barrier promoted by gluten peptides is a cause and not a result of the immune response in celiac patients,' says the lead author of the study, Dr Veronica Dodero from the Bielefeld Faculty of Chemistry. The relationship between 33-mer DGP and Celiac Disease Human leukocyte antigens (HLAs) are proteins found on the surface of cells in the body. They play a crucial role in the immune system by helping it distinguish between self (the body's own cells) and non-self (foreign substances like bacteria or viruses). In celiac disease, two specific HLA proteins, namely HLA-DQ2 and HLA-DQ8, are strongly associated with the condition. The 33-mer DGP fits perfectly with HLA-DQ2 or HLA-DQ8 and triggers an immune response, leading to inflammation and small intestine villous atrophy. This strong interaction turns the DGP into what scientists call a superantigen. For those affected, a gluten-free diet is the only lifelong therapy.

A Forage-First Approach, Elevating Equine Nutrition and Health with Premium Blends for Enhanced Digestion KIMBERLY, Idaho, Jan. 18, 2024 /PRNewswire/ -- In a stride towards innovation, Standlee proudly expands its forage-first product offerings with the introduction of Smart Carb™ Performance and Forage Plus™ Gastric Support. Formulated by Dr. Stephen Duren, Ph.D., Equine Nutritionist at Standlee, these blended forage-based pellets are carefully crafted to meet the unique nutritional needs of horses. Continue Reading Standlee Unveils Smart Carb Performance & Forage Plus Gastric Support: Elevating Equine Nutrition with Forage Blends Post this Standlee® Unveils Smart Carb™& Performance and Forage Plus™& Gastric Support "We are committed to meeting our customers' and their animals' needs, through innovation," said Scott Plew, President of Standlee Premium Products, LLC. "We aim to introduce forage products to the market that fulfill the unique needs of horses and other animals. With forage being the most important component of a horse's diet, we strive to provide each animal with the nutrition they need to continue living long and healthy lives." Designed to meet consumer demands, Smart Carb & Forage Plus pellets stand out as the perfect supplement for a range of forages. These pellets not only enhance digestion and boost palatability but also optimize microbiome function. With a low sugar and starch profile and being grain-free, they represent a blended and comprehensive nutritional choice for horses. "Smart Carb Performance and Forage Plus Gastric Support represent a leap forward in equine nutrition," said, Dr. Stephen Duren, Ph.D., Equine Nutritionist at Standlee, "With a commitment to the horse's nutrition, these forage blends offer a blend of ingredients to aid in the healing process of digestive diseases and support a healthy microbiome for horses who are prone to digestive diseases, optimizing your horse's performance." Standlee will release two new forage blends starting with: Smart Carb™ Performance Offering low sugar and low starch content, Smart Carb Performance is enriched with probiotics to optimize microbiome function and ensure your horses perform at their peak. Smart Carb is an Alfalfa and Teff based forage blend designed for horses that are carbohydrate sensitive and for horses that are at risk for carbohydrate sensitive nutritional disorders including Insulin Resistance, Cushing's Disease and Tying-Up Syndrome. Forage Plus™ Gastric Support Forage Plus Gastric Support is formulated to buffer stomach acid, support digestive tissue health, and promote a healthy gut microbiome. Using premium alfalfa, this forage blend is molasses and grain-free. The formula is the ideal recommendation for horses dealing with periods of digestive sensitivities such as gastric ulcers and leaky gut syndrome due to heightened stress from trailering and competition. "Partnering with Performance Horse Nutrition in the development of these new forage blends have allowed us to strategically expand our forage-first product line to our customers, by providing a premium forage blend with additional ingredients that streamline customers feedings routines and benefit the horses and other animals according to their unique nutritional needs," said Jessica Wright, Director of Marketing. Standlee continues to prioritize your horse's health and nutritional requirements through innovated products Smart Carb Performance and Forage Plus Gastric Support is available for retailers to order. If you want more information about Standlee's new products, please contact customer service at [email protected] or 800-398-0819. Media Library Link: About Standlee Standlee puts the health and well-being of the animals you love first by delivering the best nutrition through premium forage and highest-quality animal care products. Founded in 1981, Standlee has carefully grown and manufactured sun-cured forage to ensure high-quality and consistent nutrition. Their finished products are managed to ensure year-round supply and are delivered to customers by the largest distribution network of forage products in the United States. They provide premium forage in a variety of types and in a wide range of product formats, including pellets, cubes, chopped, and bales – To keep your animals at peak health and performance throughout the year Standlee forage is the perfect nutritional solution for horses, livestock, small animals, and poultry. Standlee has committed to providing a premium experience when purchasing their products. You can trust it was made with the same dedication as if they are caring for your own animals. Standlee is Grown for the Life We Love®. standlee.com Contact Information: Jessica Wright Director of Marketing [email protected] SOURCE Standlee