Fournier's gangrene (FG) is a type of necrotizing fasciitis affecting the abdomen or perineum. It is a polymicrobial infection that progresses to an obliterating endarteritis, causing thrombosis and subsequent tissue necrosis, allowing pathogenic invasion of interfacial planes.Patients with Fournier's gangrene typically have underlying systemic conditions that cause vascular insufficiencies or immunosuppression. This case describes a 55-year-old male patient with a medical history significant for HIV, obesity (BMI of 37), and smoking. The patient presented with generalized symptoms along with localized edema and erythema of the scrotum. Point-of-care ultrasound (POCUS) aided in evaluating the deeper structures for accurate diagnosis of Fournier's gangrene. Treatment followed current standards, including empiric antibiotics, analgesia, and surgical incision and drainage. The patient experienced an uncomplicated postoperative recovery despite his comorbidities due to prompt diagnosis and treatment.