Last update 01 Nov 2024

Meige Syndrome

Last update 01 Nov 2024

Basic Info

Synonyms

Blepharospasm - oromandibular dystonia, Blepharospasm Oromandibular Dyskinesia, Blepharospasm Oromandibular Dystonia

+ [46]

Introduction

A syndrome characterized by orofacial DYSTONIA; including BLEPHAROSPASM; forceful jaw opening; lip retraction; platysma muscle spasm; and tongue protrusion. It primarily affects older adults, with an incidence peak in the seventh decade of life. (From Adams et al., Principles of Neurology, 6th ed, p108)

Drugs associated with Meige Syndrome

AbobotulinumtoxinA (Ipsen Biopharm Ltd)

Target

SNAP25

Mechanism

SNAP25 inhibitors

Active Org.

Ipsen SA [+2]

Originator Org.

Ipsen Biopharm Ltd.

Active Indication

Facial Dermatoses [+7]

Inactive Indication

Low Back Pain [+9]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date28 Jan 2009

Clinical Trials associated with Meige Syndrome

NCT06292559 / RecruitingNot ApplicableIIT

A Randomized Prospective Study Between STN-DBS and GPi-DBS in Meige Syndrome

Deep-brain stimulation (DBS) is an effective treatment for patients with Meige syndrome. The globus pallidus interna (GPi) and the subthalamic nucleus (STN) are both accepted targets for this treatment. Researchers designed this study to compare the 12-month outcomes for patients who undergo bilateral stimulation of the GPi or STN.

Start Date30 Nov 2023

Sponsor / Collaborator

Qilu Hospital of Shandong University

ChiCTR2000033481 / SuspendedEarly Phase 1IIT

Evaluating the safety and technical effectiveness of bilateral facial and trigeminal nerve combing for the treatment of Meige's syndrome: a first-in-human multiple center clinical trial in China

Start Date01 Jul 2020

Sponsor / Collaborator-

ChiCTR2000032852 / RecruitingNot ApplicableIIT

Clinical study of deep brain stimulation in the treatment of Meige syndrome

Start Date25 May 2020

Sponsor / Collaborator-

100 Clinical Results associated with Meige Syndrome

100 Translational Medicine associated with Meige Syndrome

0 Patents (Medical) associated with Meige Syndrome

419

Literatures (Medical) associated with Meige Syndrome

01 Nov 2024·EXPLORE

Acupuncture for Meige syndrome: A case report

Article

Author: Zhou, Yihao ; Yang, Siyu ; Wang, Dongyan ; Huo, Hong

INTRODUCTIONMeige syndrome (MS) is a cranial dystonia disorder characterized by blepharospasm and oromandibular dystonia. Current treatments include botulinum toxin therapy, oral medications, and surgical interventions. Here, we present a case that the patient's symptoms improved significantly after treatment with acupuncture.CASE DESCRIPTIONA 72-year-old woman came to our acupuncture clinic with eyelid twitching and jaw muscle tension. She described being diagnosed with MS two years ago due to the same symptoms, and her symptoms gradually worsened over the past six months. After 4 weeks of acupuncture treatment, the patient's MS symptoms improved significantly.CONCLUSIONAcupuncture may be a potentially salvage treatment option for MS.

01 Oct 2024·Neuroradiology

CT-guided radiofrequency ablation of facial and mandibular nerves in the treatment of compound Meige’s syndrome

Article

Author: Huang, Hao ; Yao, Ming ; Zhou, Qinghe ; Huang, Bing ; Li, Xue ; Du, Xindan ; Zhao, Xian ; Lin, Huidan

AbstractThis retrospective study examined the clinical outcomes and complications in 6 cases of compound Meige’s syndrome, presenting with blepharospasm and masticatory muscle spasm, following treatment with CT-guided radiofrequency ablation targeting bilateral facial nerves and mandibular branches of the trigeminal nerve. After the operation, the symptoms of eyelid spasm and masticatory muscle spasm resolved, but mild facial paralysis and numbness of mandibular nerve innervation persisted. Follow-up for 4–28 months showed that the symptoms of facial paralysis resolved within 2–5 (3.17 ± 0.94) months after the operation, whereas the numbness in the mandibular region persisted, accompanied by a decrease in masticatory function. During the follow-up period, none of the 6 patients experienced a recurrence of Meige’s syndrome. These findings suggest that CT-guided radiofrequency ablation of the bilateral facial nerve and mandibular branches of the trigeminal nerve may offer a promising approach to treating compound Meige’s syndrome.

01 Sep 2024·Asian Journal of Surgery

Computed tomography navigation radiofrequency ablation for Meige's syndrome: A game-changer in treatment

Article

Author: Du, Xindan ; Zhao, Xian ; Yao, Ming ; Ma, Ying ; Lin, Huidan ; Zhou, Qinghe ; Li, Xue ; Huang, Bing ; Huang, Hao

BACKGROUNDMeige's syndrome severely impacts quality of life. Current treatments struggle to balance cost, risk, and effectiveness.METHODSPatients with blepharospasm were treated with facial nerves partial radiofrequency ablation guided by CT. Treatment efficacy, complications, and recurrences were evaluated during follow-up.RESULTS116 facial nerves in 58 patients with Meige's syndrome were treated using CT guidance. The average temperature at the end of radiofrequency treatment was 77.93 ± 9.8 °C, and the procedure lasted an average of 30.79 ± 7.69 min. Spasms stopped after treatment, but mild facial paralysis remained. Follow-ups ranging from 12 to 57 months showed that facial paralysis improved in an average of 3.12 ± 0.94 months. Nine patients had unilateral recurrence within 6-13 months, and three had bilateral recurrence at 14, 18, and 22 months.CONCLUSIONSPartial radiofrequency ablation of the facial nerve through percutaneous access to the bilateral stylomastoid foramen using CT navigation is an effective, safe, promising treatment for blepharospasm in Meige's syndrome patients.

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