Paroxysmal Hemicrania

Extension maintains listing through March 17, 2026ROCKAWAY, N.J., Oct. 17, 2023 (GLOBE NEWSWIRE) -- electroCore, Inc. (Nasdaq: ECOR), a commercial stage bioelectronic medicine and wellness company, announced today that gammaCore therapy will continue to be listed in the United Kingdom’s National Health Service (NHS) Supply Chain catalogue for an additional two years through March 17, 2026. The listing, which commenced on June 4, 2019, was scheduled to terminate on March 18, 2024. “We are delighted the NHS Supply Chain intends to continue to include the gammaCore device within their framework agreement, commencing March 2024 through March 2026 with an option to extend for a further 2 years,” stated Mitch DeShon, Vice President of Global Sales & Business Development at electroCore. “Inclusion in this catalogue helps ensure gammaCore therapy is broadly accessible to patients across the UK who may benefit from non-invasive vagus nerve stimulation and adds increased validation to the benefits realized by patients in the UK using gammaCore therapy.” About electroCore, Inc.electroCore, Inc. is a commercial stage bioelectronic medicine and wellness company dedicated to improving health through its non-invasive vagus nerve stimulation (“nVNS”) technology platform. Our focus is the commercialization of medical devices for the management and treatment of certain medical conditions and consumer product offerings utilizing nVNS to promote general wellbeing and human performance in the United States and select overseas markets. For more information, visit www.electrocore.com. About gammaCore™gammaCore™ (nVNS) is the first non-invasive, hand-held medical therapy applied at the neck to treat migraine and cluster headache through the utilization of a mild electrical stimulation to the vagus nerve that passes through the skin. Designed as a portable, easy-to-use technology, gammaCore is self-administered by patients, as needed, without the potential side effects associated with commonly prescribed drugs. When placed on a patient’s neck over the vagus nerve, gammaCore stimulates the nerve’s afferent fibers, which may lead to a reduction of pain in patients. gammaCore™ is intended to provide non-invasive vagus nerve stimulation (nVNS) on the side of the neck for preventive treatment of migraine and the acute treatment of pain associated with migraine in patients 12 and older. gammaCore is also indicated for adjunctive use for preventive treatment of cluster headache, acute treatment of episodic cluster headache, and treatment of hemicrania continua and paroxysmal hemicrania in adult patients. gammaCore should not be used by people with an active implantable medical device. Please refer to gammaCore.com or the Instructions for Use for complete safety information, including indications, contraindications, warnings, cautions, and instructions. Forward-Looking Statements This press release and other written and oral statements made by representatives of electroCore may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include, but are not limited to, statements about electroCore's business prospects and clinical and product development plans; its pipeline or potential markets for its technologies; the timing, outcome and impact of regulatory, clinical and commercial developments; the business, operating or financial impact of such studies; the commercial potential of nVNS generally and gammaCore in particular in the UK and other statements that are not historical in nature, particularly those that utilize terminology such as "anticipates," "will," "expects," "believes," "intends," other words of similar meaning, derivations of such words and the use of future dates. Actual results could differ from those projected in any forward-looking statements due to numerous factors. Such factors include, among others, the ability to raise the additional funding needed to continue to pursue electroCore’s business and product development plans, the inherent uncertainties associated with developing new products or technologies, the ability to commercialize gammaCore™, the potential impact and effects of COVID-19 on the business of electroCore, electroCore’s results of operations and financial performance, and any measures electroCore has and may take in response to COVID-19 and any expectations electroCore may have with respect thereto, competition in the industry in which electroCore operates and overall market conditions. Any forward-looking statements are made as of the date of this press release, and electroCore assumes no obligation to update the forward-looking statements or to update the reasons why actual results could differ from those projected in the forward-looking statements, except as required by law. Investors should consult all of the information set forth herein and should also refer to the risk factor disclosure set forth in the reports and other documents electroCore files with the SEC available at www.sec.gov. Contact:ECOR Investor Relations(973) 302-9253investors@electrocore.com

ROCKAWAY, N.J., July 25, 2023 (GLOBE NEWSWIRE) -- electroCore, Inc. (Nasdaq: ECOR), a commercial-stage bioelectronic medicine and wellness company, today announced the publication of a peer reviewed manuscript, Effect of Transcutaneous Cervical Vagus Nerve Stimulation on Declarative and Working Memory in Patients with Posttraumatic Stress Disorder (PTSD): A Pilot Study, in the Journal of Affective Disorders. The study was conducted with the support of Emory University, The Georgia Institute of Technology and the Atlanta Veteran’s Affairs Medical Center and was sponsored by a Department of Defense Small Business Technology Transfer grant (DoD STTR). PTSD is an extreme mental health condition associated with changes in multiple neurophysiological systems such as inflammation and the autonomic nervous system and contributing to deficits in memory. Many patients have limited or no response to currently available treatments for PTSD symptoms and associated cognitive dysfunction. According to the American Psychiatric Association, exposure to traumas including accidents or other life-threatening incidents can initiate the development of PTSD, a complex syndrome involving core symptoms of hyperarousal, avoidance and re-experiencing symptoms, and associated decreases in concentration and memory1,2 (Hou et al., 2007; Williams and First, 2013). Vagus Nerve Stimulation (VNS) has been shown in preliminary studies to enhance function when paired with cognitive and motor tasks. The randomized double-blinded study enrolled fifteen patients (nVNSActive = 8; nVNSSham =7), was conducted over the course of three months of twice daily home-based nVNS self-administered treatments and assessed the effectiveness of nVNS on declarative and working memory in patients with PTSD. The study concluded the active group developed better attention and recall of paragraphs encoded with stimulation as well as for working memory tasks as compared to sham. The improvement in working memory for patients with PTSD who used nVNS compared to sham was statistically significant at 4 weeks (57.1%; p=0.01) and continued to improve through 8 weeks (91.4%; p=0.03). Dr. Douglas Bremner, Professor of Psychiatry and Radiology at Emory University School of Medicine and the primary investigator for the study, commented, “nVNS continues to demonstrate its potential as a safe, convenient and potentially effective treatment for people suffering from PTSD. The improvements in memory seen in this study, complement our previous research which has shown the beneficial effects of nVNS on some of the basic mechanisms that lead to, and can exacerbate, PTSD3,4.This longitudinal study shows benefit for cognitive symptoms associated with PTSD and suggests that nVNS may improve work and social functioning for patients with PTSD.” “We congratulate and thank Dr. Bremner, Dr. Inan, Dr. Choudhary and the clinical and research teams at Emory University, Georgia Tech University and the Atlanta VA for their support of this study,” commented Dan Goldberger, Chief Executive Officer at electroCore. “We look forward to the results of several larger on-going government sponsored studies of nVNS as a treatment for PTSD and other future indications.” The full publication is available at: https://www.sciencedirect.com/science/article/abs/pii/S0165032723008625 The content of the paper is solely the responsibility of the authors and does not necessarily represent the official views of study sponsors. About electroCore, Inc.electroCore, Inc. is a commercial stage bioelectronic medicine and wellness company dedicated to improving health through its non-invasive vagus nerve stimulation (“nVNS”) technology platform. Our focus is the commercialization of medical devices for the management and treatment of certain medical conditions and consumer product offerings utilizing nVNS to promote general wellbeing and human performance in the United States and select overseas markets. For more information, visit www.electrocore.com. About gammaCore™gammaCore™ (nVNS) is the first non-invasive, hand-held medical therapy applied at the neck to treat migraine and cluster headache through the utilization of a mild electrical stimulation to the vagus nerve that passes through the skin. Designed as a portable, easy-to-use technology, gammaCore is self-administered by patients, as needed, without the potential side effects associated with commonly prescribed drugs. When placed on a patient’s neck over the vagus nerve, gammaCore stimulates the nerve’s afferent fibers, which may lead to a reduction of pain in patients. gammaCore™ is intended to provide non-invasive vagus nerve stimulation (nVNS) on the side of the neck for preventive treatment of migraine and the acute treatment of pain associated with migraine in patients 12 and older. gammaCore is also indicated for adjunctive use for preventive treatment of cluster headache, acute treatment of episodic cluster headache, and treatment of hemicrania continua and paroxysmal hemicrania in adult patients. gammaCore should not be used by people with an active implantable medical device. Please refer to gammaCore.com or the Instructions for Use for complete safety information, including indications, contraindications, warnings, cautions, and instructions. Forward-Looking Statements This press release and other written and oral statements made by representatives of electroCore may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include, but are not limited to, statements about electroCore's business prospects and clinical and product development plans; its pipeline or potential markets for its technologies; the timing, outcome and impact of regulatory, clinical and commercial developments; the Company’s business prospects in cognitive symptoms associated with PTSD and other statements that are not historical in nature, particularly those that utilize terminology such as "anticipates," "will," "expects," "believes," "intends," other words of similar meaning, derivations of such words and the use of future dates. Actual results could differ from those projected in any forward-looking statements due to numerous factors. Such factors include, among others, the ability to raise the additional funding needed to continue to pursue electroCore’s business and product development plans, the inherent uncertainties associated with developing new products or technologies, the ability to commercialize gammaCore™, the potential impact and effects of COVID-19 on the business of electroCore, electroCore’s results of operations and financial performance, and any measures electroCore has and may take in response to COVID-19 and any expectations electroCore may have with respect thereto, competition in the industry in which electroCore operates and overall market conditions. Any forward-looking statements are made as of the date of this press release, and electroCore assumes no obligation to update the forward-looking statements or to update the reasons why actual results could differ from those projected in the forward-looking statements, except as required by law. Investors should consult all of the information set forth herein and should also refer to the risk factor disclosure set forth in the reports and other documents electroCore files with the SEC available at www.sec.gov. Contact:ECOR Investor Relations(973) 302-9253investors@electrocore.com ____________________1 Hou, C., Liu, J., Wang, K., Li, L., Liang, M., He, Z., Liu, Y., Zhang, Y., Li, W., Jiang, T., 2007. Brain responses to symptom provocation and trauma-related short-term memory recall in coal mining accident survivors with acute severe PTSD. Brain Res. 1144, 165–174. https://doi.org/10.1016/j.brainres.2007.01.0892 Williams, J.B.W., First, M., 2013. Diagnostic and Statistical Manual of Mental Disorders [WWW Document]. Encycl. Soc. Work. https://doi.org/10.1093/acrefore/9780199975839.013.1043 Bremner, J.D., Wittbrodt, M.T., Gurel, N.Z., Shandhi, M.H., Gazi, A.H., Jiao, Y., Levantsevych, O.M., Huang, M., Beckwith, J., Herring, I., Murrah, N., Driggers, E.G., Ko, Y.-A., Alkhalaf, M.L., Soudan, M., Shallenberger, L., Hankus, A.N., Nye, J.A., Park, J., Woodbury, A., Mehta, P.K., Rapaport, M.H., Vaccarino, V., Shah, A.J., Pearce, B.D., Inan, O.T., 2021b. Transcutaneous Cervical Vagal Nerve Stimulation in Patients with Posttraumatic Stress Disorder (PTSD): A Pilot Study of Effects on PTSD Symptoms and Interleukin-6 Response to Stress. J. Affect. Disord. Rep. 6, 100190. https://doi.org/10.1016/j.jadr.2021.1001904 Wittbrodt, M.T., Gurel, N.Z., Nye, J.A., Shandhi, M.M.H., Gazi, A.H., Shah, A.J., Pearce, B.D., Murrah, N., Ko, Y. A., Shallenberger, L.H., Vaccarino, V., Inan, O.T., Bremner, J.D., 2021. Noninvasive Cervical Vagal Nerve Stimulation Alters Brain Activity During Traumatic Stress in Individuals With Posttraumatic Stress Disorder. Psychosom. Med. 83, 969. https://doi.org/10.1097/PSY.0000000000000987

ROCKAWAY, N.J., July 06, 2023 (GLOBE NEWSWIRE) -- electroCore, Inc. (Nasdaq: ECOR), a commercial-stage bioelectronic medicine and wellness company, today announced that its gammaCore non-invasive vagus nerve stimulation (“nVNS”) has been selected to be a part of studies on effects of cannabinoids and alternative care on athlete pain management and performance. The NFL and NFLPA are jointly awarding two research grants to independent medical researchers at the American Society of Pain and Neuroscience (ASPN) and Emory University. The grants will fund investigations into innovative, first-of-their-kind, alternative pain management methods that could benefit NFL players, and society at large. These awards are the second round chosen by the NFL-NFLPA Joint Pain Management Committee (PMC), which aims to facilitate research to better understand and improve potential alternative pain management treatments for NFL players. nVNS will be used in “A Pilot Study Assessing Non-Invasive Treatment of Refractory Post-Concussion Headache Pain," led by Dr. Erika Petersen and researchers at the American Society of Pain and Neuroscience (ASPN). The randomized study will compare nVNS and cannabidiol (CBD) in contact sport athletes experiencing Post-Traumatic Headache (PTH) to current standard of care treatment. PTH is one of the most common aftereffects of concussion or other traumatic brain injury. PTH is a poorly treated, highly debilitating headache disorder where medications and other options for treatment are not very effective. Given that nearly 4 million Americans are diagnosed with concussions annually, PTH should be considered a substantial public health concern. The pilot data gathered in this study will guide future investigations into treatment of patients with post-traumatic headache. “We are thrilled to have been selected to be part of a study that focuses on alternative care options for pain management and performance,” said Dr. Peter Staats, Chief Medical Officer at electroCore. “Post-Traumatic Headache as an area of focus for electroCore is a natural progression from our cleared indications in primary headache. We are hopeful that nVNS will prove to be a pain management option for athletes, military personnel, or anyone suffering from pain associated with PTH.” About the NFL-NFLPA Joint Pain Management CommitteeThe Joint Pain Management Committee is comprised of medical experts appointed by the league and the NFLPA. The Committee works to establish uniform standards for club practices and policies regarding pain management and the use of prescription medications by NFL players. About electroCore, Inc.electroCore, Inc. is a commercial stage bioelectronic medicine and wellness company dedicated to improving health through its non-invasive vagus nerve stimulation (“nVNS”) technology platform. Our focus is the commercialization of medical devices for the management and treatment of certain medical conditions and consumer product offerings utilizing nVNS to promote general wellbeing and human performance in the United States and select overseas markets. For more information, visit www.electrocore.com. About gammaCore™gammaCore™ (nVNS) is the first non-invasive, hand-held medical therapy applied at the neck to treat migraine and cluster headache through the utilization of a mild electrical stimulation to the vagus nerve that passes through the skin. Designed as a portable, easy-to-use technology, gammaCore is self-administered by patients, as needed, without the potential side effects associated with commonly prescribed drugs. When placed on a patient’s neck over the vagus nerve, gammaCore stimulates the nerve’s afferent fibers, which may lead to a reduction of pain in patients. gammaCore™ is intended to provide non-invasive vagus nerve stimulation (nVNS) on the side of the neck for preventive treatment of migraine and the acute treatment of pain associated with migraine in patients 12 and older. gammaCore is also indicated for adjunctive use for preventive treatment of cluster headache, acute treatment of episodic cluster headache, and treatment of hemicrania continua and paroxysmal hemicrania in adult patients. gammaCore should not be used by people with an active implantable medical device. Please refer to gammaCore.com or the Instructions for Use for complete safety information, including indications, contraindications, warnings, cautions, and instructions. Forward-Looking Statements This press release may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include, but are not limited to, statements regarding the results from work being conducted as part of the two research grants to independent medical researchers at the American Society of Pain and Neuroscience (ASPN) and Emory University on effects of cannabinoids and alternative care on athlete pain management and performance, statements about electroCore's business prospects and clinical and product development plans; its pipeline or potential markets for its technologies, electroCore's business prospects, its sales and marketing and product development plans, future cash flow projections, anticipated costs, its product portfolio or potential markets for its technologies, the availability and impact of payor coverage, the potential of nVNS generally and gammaCore nVNS in particular to concussion and PTH, and other statements that are not historical in nature, particularly those using terminology such as "anticipates," "expects," "believes," "intends," other words of similar meaning, derivations of such words and the use of future dates. Actual results could differ from those projected in any forward-looking statements due to numerous factors. Such factors include, among others, the ability to obtain additional financing necessary to continue electroCore's business, sales and marketing and product development plans, the uncertainties inherent in the development of new products or technologies, the ability to successfully commercialize TAC-STIM™, competition in the industry in which electroCore operates and general market conditions. The results of earlier preclinical studies and clinical trials may not be predictive of results of future preclinical studies, clinical trials, or commercial success. All forward-looking statements are made as of the date of this press release, and electroCore undertakes no obligation to update forward-looking statements or to update the reasons why actual results could differ from those projected in the forward-looking statements, except as required by law. Investors should refer to all information set forth in this document and should also refer to the disclosure of risk factors set forth in the reports and other documents electroCore files with the SEC, available at www.sec.gov. Contact:ECOR Investor Relations(973) 302-9253investors@electrocore.com