Last update 01 Nov 2024

Schizophrenia, Disorganized

Last update 01 Nov 2024

Basic Info

Synonyms

Disorganised schizophrenia, Disorganized Schizophrenia, Disorganized Schizophrenias

+ [55]

Introduction

A type of schizophrenia characterized by frequent incoherence; marked loosening of associations, or grossly disorganized behavior and flat or grossly inappropriate affect that does not meet the criteria for the catatonic type; associated features include extreme social withdrawal, grimacing, mannerisms, mirror gazing, inappropriate giggling, and other odd behavior. (Dorland, 27th ed)

Drugs associated with Schizophrenia, Disorganized

Asenapine Maleate

Target

5-HT2A receptor x D2 receptor

Mechanism

5-HT2A receptor antagonists [+1]

Active Org.

Allergan Sales LLC [+5]

Originator Org.

Merck Sharp & Dohme Corp.

Active Indication

Bipolar I disorder [+3]

Inactive Indication

Paranoid Schizophrenia [+5]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date13 Aug 2009

BCM857

Target-

Mechanism-

Active Org.

Shanghai Bocimed Pharmaceutical Co., Ltd.

Originator Org.

Shanghai Bocimed Pharmaceutical Co., Ltd.

Active Indication

Schizophrenia [+1]

Inactive Indication-

Drug Highest PhasePhase 1

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Schizophrenia, Disorganized

CTRI/2024/03/064449 / Not yet recruitingNot ApplicableIIT

INTREPID - Deepening and Broadening knowledge of Psychoses Globally

Start Date01 Jun 2024

Sponsor / Collaborator

The Medical Research Council

CTRI/2023/08/056169 / Not yet recruitingPhase 3

Adjuvant HD-tDCS for social cognition in schizophrenia and its correlation with serum oxytocin: A randomised sham controlled study - NIL

Start Date17 Aug 2023

Sponsor / Collaborator

Central Institute of Psychiatry

CTRI/2023/08/056148 / Not yet recruitingPhase 3

Effect of adjunctive Memantine on cognitive functions, metabolic profile and brain neurometabolites in Clozapine-treated patients of Schizophrenia: A 1H-MRS Study - NIL

Start Date17 Aug 2023

Sponsor / Collaborator

Central Institute of Psychiatry

100 Clinical Results associated with Schizophrenia, Disorganized

100 Translational Medicine associated with Schizophrenia, Disorganized

0 Patents (Medical) associated with Schizophrenia, Disorganized

285

Literatures (Medical) associated with Schizophrenia, Disorganized

01 Sep 2024·Schizophrenia Research: Cognition

Decision-making under risk and its correlates in schizophrenia

Article

Author: Shovestul, Bridget ; Lamberti, J Steven ; Reda, Stephanie ; Dong, Xiaoyu ; Dodell-Feder, David ; Dudek, Emily ; Saxena, Abhishek

Schizophrenia spectrum disorders (SSD) are associated with pervasive cognitive impairments, including deficits in decision-making under risk. However, there is inconclusive evidence regarding specific mechanisms underlying altered decision-making patterns. In this study, participants (33 SSD and 28 non-SSD) completed the Columbia Card Task, an explicit risk-taking task, to better understand risk preference and adjustment in dynamic decision-making. We found that while there is no group difference in overall risk-taking, risk preference, or optimal decision-making, risk adjustment to contextual factors (e.g., loss probability) is blunted in SSD. We also found associations between risk-taking/suboptimal decision-making and disorganized symptoms, excited symptoms, and role functioning, but no associations between decision-making and working memory. These results suggest that during a complex, dynamic risk-taking task, individuals with SSD exhibit less adaption to changing information about risk, which may reflect risk imperception.

01 Jul 2024·Radiology

Case 327: Exogenous Lipoid Pneumonia

Article

Author: Parrot, Antoine ; Decavèle, Maxens ; Antoine, Martine ; Pichon, Jérémie ; Gibelin, Aude ; Fajac, Anne ; Fartoukh, Muriel ; Milon, Audrey

HISTORYA 58-year-old male patient with an active smoking status was admitted twice to the intensive care unit (ICU) of a tertiary referral thoracic center for severe hypercapnic acute respiratory failure and persistent bilateral chest radiograph opacities that were unchanged over the course of the two ICU admissions within a 3-month period. The patient had obesity (body mass index, 36), stage 3 vascular chronic renal insufficiency, and hebephrenic schizophrenia treated with haloperidol, carbamazepine, and cyamemazine. He reported chronic dyspnea on exertion, which worsened for 6 months. At the second ICU admission, the patient was afebrile, with a blood pressure of 160/72 mm Hg and pulse oximetry of 93% on 6 L/min oxygen therapy through a nonrebreathing mask. Physical examination showed signs of respiratory failure with wheezing and active abdominal expiration, and bilateral pulmonary crackles without chest pain, hemoptysis, clubbing, or signs of cardiac failure. The patient had no peripheral lymphadenopathy and no enlarged spleen. Blood gases (on 6 L/min oxygen) showed respiratory acidosis (pH, 7.15 [normal range, 7.38-7.42]; PaO₂ level, 67 mm Hg [normal range, 80-100 mm Hg]; PaCO₂ level, 102 mm Hg [normal range, 38-42 mm Hg]; bicarbonate [HCO_3-], 29 mmol/L [normal range, 22-27 mmol/L]). Noninvasive ventilation was initiated. Imaging performed during the second ICU hospitalization included CT and MRI of the chest without contrast enhancement, and fluorine 18 (¹⁸F) fluorodeoxyglucose (FDG) PET/CT.

01 Jun 2024·International Journal of Surgery Case Reports

Genital self-mutilation in psychiatric patients: A case report

Author: El Omri, Ghassane ; Rachid, Moussaab ; Heddat, Abdeljalil ; Taghouan, Anas ; Younes, Houry ; Rais, Hamza

INTRODUCTIONGenital self-mutilation presents significant surgical challenges, particularly when complicated by psychiatric disorders. This case highlights the critical role of surgical intervention in the management of self-inflicted severe penile injuries and underscores the need to integrate surgical and psychiatric care to optimise results.CASE PRESENTATIONA 43-year-old man, with progressive psychiatric issues, self-inflicted penile amputation. He arrived late in the emergency room with a poorly preserved amputated penis, complicating potential reimplantation. The surgeons extensively debrided and created a urethrostomy on the anterior scrotum wall, preparing for future phalloplasty. This planning ensured tissue viability and minimised postoperative complications. Early psychiatric evaluations revealed hebephrenic schizophrenia. Unfortunately, after psychiatric stabilisation, he was lost to follow-up and was not present for phalloplasty.DISCUSSIONSevere penile lesions require restoration of appearance, preservation of functions, and minimisation of complications. The surgical approach depends on the hospital capabilities, expertise, and patient condition, our patient's case required an anterior urethral anastomosis of the scrotum wall in consideration of phalloplasty. Pairing surgical intervention with immediate psychiatric care is crucial for optimal outcomes. However, the loss of follow-up postpsychiatric discharge in our patient highlights the need for improved monitoring to ensure adherence to treatment.CONCLUSIONSThis case highlights the interaction between severe genital trauma, psychiatric instability, and surgical management in patients who engage in self-genital mutilation. It underscores the importance of a multidisciplinary approach that involves both surgical and psychiatric. Enhanced strategies for psychiatric involvement and monitoring are crucial, especially for people scheduled for complex reconstructive surgeries such as phalloplasty.

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