Ehlers-Danlos Syndrome

OXFORD, UK and CLEVELAND, Ohio, US, 11th September 2024 – The Oxford-Harrington Rare Disease Centre (‘OHC’), a partnership between the University of Oxford, UK and Harrington Discovery Institute at University Hospitals, Cleveland, Ohio, aimed at driving cutting-edge rare disease breakthroughs, announces the appointment of Baroness Nicola Blackwood to the OHC Advisory Council. In her position on OHC’s Advisory Council, Baroness Blackwood will contribute to advancing OHC’s mission to drive life-changing discoveries in rare disease, with a particular focus on addressing critical unmet needs in the UK. Baroness Blackwood is Chair of both Genomics England and Oxford University Innovation. She is also a Board Member of the biotechnology company BioNTech and investment fund RTW Biotech Opportunities. She brings extensive experience in healthcare policy and innovation, including her involvement in the UK’s impactful 100,000 Genomes Project, which continues to shape the lives of those with rare diseases. She has also led on NHS innovation, UK rare disease and regulation, and global health security through her previous roles as Minister in the UK Government’s Department for Health and Social Care. Her extensive professional experience combined with her own personal journey since being diagnosed with Ehlers-Danlos Syndrome will bring a unique perspective to OHC’s Advisory Council. Professor Sir John Bell, President of the Ellison Institute of Technology (EIT) Oxford, member of the OHC Steering Committee and Chair of the OHC Advisory Council, said: “We are delighted to welcome Nicola to the OHC Advisory Council. Nicola’s extensive experience in healthcare policy and her dedication to advancing medical innovation makes her the perfect fit for our mission. We look forward to working with her to transform cutting-edge science into life-changing therapies for those in need.” Baroness Nicola Blackwood commented: “Having dedicated my career to improving healthcare outcomes for patients with rare diseases, I am honoured to be joining OHC’s Advisory Council. From both a professional and personal perspective, I have witnessed how much diagnosis and treatment of a rare disease can change someone’s life. I am delighted to be joining OHC at this pivotal stage as they continue to progress towards driving meaningful change by developing innovative solutions for patients in need.” Matthew Wood, Director and Chief Scientific Officer of the OHC, and Professor of Neuroscience in Oxford’s Department of Paediatrics, added: “Nicola’s dedication to UK life sciences and the rare disease community is truly inspiring, and her advocacy efforts have significantly advanced healthcare in this area. Her contribution to shaping healthcare policy and her unwavering commitment to patients makes her a vital asset in achieving our objectives. We are all thrilled that Nicola has decided to join us at the OHC, and I look forward to collaborating with her to reach our goal of delivering 40 rare disease drugs in the next ten years.” The OHC Advisory Council includes the following founding members: Lord David Cameron, John Crowley, Professor Sir John Bell, Jonathan Stamler, MD, and Ronald G. Harrington. *** Notes to Editors About Baroness Nicola BlackwoodNicola is a leader in science and entrepreneurship. She is a member of the House of Lords, and Chair of Genomics England and Oxford University Innovation. She is also a Board member of the biotechnology company, BioNTech and investment fund RTW Biotech Opportunities. Nicola served as a Minister in the UK Government Department for Health and Social Care under two Prime Ministers. As Minister for Innovation, she led on Life Sciences, NHS Data and Digital Transformation, and Global Health Security. She was the first female Member of Parliament (MP) for Oxford and was elected by MPs of all parties to Chair the House of Commons Science and Tech Committee. She remains one of the youngest committee chairs in British history and the only woman to have chaired the Commons Science & Tech Committee. About Rare DiseasesMore than 400 million people worldwide are living with a rare disease, and approximately 50 percent are children. There are about 7,000 known rare diseases, with new diseases being discovered every day. A rare disease affects one in 10 Americans, or 10 percent of the US population. Similarly, Europe has approximately 30 million people who suffer from a rare disease. The majority of all rare diseases are genetic in origin, which means they are present throughout a person’s life. Only five percent of rare diseases have a treatment approved by the US Food and Drug Administration (FDA) and similar estimates have been made for treatments approved by the European Medicine Agency (EMA). Therefore, someone with a rare disease today faces a lifelong, often life-threatening, condition with little hope for a cure, or even an effective treatment option. About Oxford-Harrington Rare Disease CentreThe Oxford-Harrington Rare Disease Centre (OHC) is a partnership between the University of Oxford, UK and Harrington Discovery Institute at University Hospitals, in Cleveland, Ohio, US. The OHC combines world-leading strengths in research and therapeutics development from across these organizations to set the science and innovation agenda and drive cutting-edge rare disease breakthroughs to address the unmet need in rare diseases across the globe to deliver major clinical impact for patients. For more information, visit: OxfordHarrington.org | X About the University of OxfordThe University of Oxford is rated the best in the world for medicine and life sciences, and it is home to the UK’s top-ranked medical school. It has one of the largest clinical trial portfolios in the UK and great expertise in taking discoveries from the lab into the clinic. Partnerships with the local NHS Trusts enable patients to benefit from close links between medical research and healthcare delivery. The University of Oxford’s Medical Sciences Division is one of the largest biomedical research centres in Europe, with over 2,500 people involved in research and more than 2,800 students. For more information, visit: www.ox.ac.uk About Harrington Discovery InstituteThe Harrington Discovery Institute at University Hospitals in Cleveland, Ohio – part of The Harrington Project for Discovery & Development – is a translational accelerator that advances promising discoveries from academic labs into the clinic for the benefit of patients and society. The institute was created in 2012 with a $50 million founding gift from the Harrington family and is a prime example of the commitment they share with University Hospitals to a Vision for a ‘Better World’. For more information, visit: HarringtonDiscovery.org| LinkedIn | X Media contacts: UK/ EU – MEDiSTRAVA Sylvie Berrebi / Mark SwallowOHC@medistrava.com US – For University HospitalsAnsley Kelmansley.kelm@UHhospitals.org

FDA advisory committee voted favorably that the data support arimoclomol as effective treatment for patients with NPC; PDUFA date of September 21, 2024 Pro forma June 30, 2024, cash, cash equivalents, investments and net proceeds from underwritten public offering total $113.8 million following the closing on August 12, 2024 Conference call scheduled for today, August 13, 2024, at 4:30 p.m. ET CELEBRATION, Fla., Aug. 13, 2024 (GLOBE NEWSWIRE) -- Zevra Therapeutics, Inc. (NasdaqGS: ZVRA) (Zevra, or the Company), a rare disease therapeutics company, today provided corporate updates and reported its financial results for the second quarter ended June 30, 2024. “During the second quarter, we made steady progress executing on our strategic objectives,” said Neil F. McFarlane, President and Chief Executive Officer of Zevra. “We are encouraged by favorable vote from the FDA’s Genetic Metabolic Diseases Advisory Committee, that data presented support that arimoclomol is effective in the treatment in patients with Niemann Pick disease type C. While the vote is non-binding, we believe it is an important factor as the FDA completes its consideration for approval. Additionally, we continue the launch of OLPRUVA with a keen focus on driving patient awareness and intend to use the same commercial team to launch arimoclomol, if approved. Additionally, we expect to meet with the FDA to discuss the design of a pivotal Phase 3 trial to study KP1077 in idiopathic hypersomnia at the end of third quarter.” “We continue to be prudent in our capital allocation as we focus on creating long-term value for stockholders,” said R. LaDuane Clifton, Zevra’s Chief Financial Officer and Treasurer. “Our recent underwritten offering provided net proceeds to the Company of $64.5 million, along with attracting a cadre of institutional investors well known as long term supporters of innovation and building momentum as we lean into our near-term catalysts while also extending our cash runway.” Q2 2024 Corporate Highlights: Arimoclomol On August 2, 2024, the U.S. Food and Drug Administration’s (FDA) newly formed Genetic Metabolic Diseases Advisory Committee (the “GeMDAC”) convened for the first time and discussed the benefits and risks of arimoclomol.The GeMDAC reviewed comments received from independent experts, NPC patients, and patient advocacy group representatives, and voted favorably that arimoclomol is effective in the treatment of NPC.On Friday, August 9, 2024, the Company received the first round of labeling comments, and is working closely with the FDA. OLPRUVA On June 18, 2024, announced transition of specialty pharmacy partner to Orsini.Increased OLPRUVA reimbursement coverage to 75% of covered lives and improved preferred status on formulary plans. Added nine (9) new patient enrollments during Q2 2024, which is defined as a prescription for a patient on the Quick Start program or receiving a paid dispense of OLPRUVA. KP1077 On June 3, 2024, presented positive topline data from its Phase 2 study in patients with idiopathic hypersomnia (IH) at the SLEEP 2024 Annual Meeting. The Company submitted a briefing book to the FDA for an end-of-Phase 2 meeting to be held at the end of Q3 2024. Celiprolol Restarted recruitment for the Phase 3 DiSCOVER trial of celiprolol in patients with Vascular Ehler-Danlos Syndrome (VEDS). Corporate On April 5, 2024, the Company entered into a $100 million credit facility with leading biotech investors, Perceptive Advisors and Healthcare Royalty Partners.On June 25, 2024, the Company announced the appointment of Rahsaan Thompson as Chief Legal Officer, Secretary and Compliance Officer, and Alison Peters as Chief People Officer, bringing expertise that will support the next phase of the Company’s growth. Overview of Q2 2024 Financial Results: Net revenue for Q2 2024 was $4.4 million, compared to net revenue of $8.5 million in Q2 2023. The components of revenue during the second quarter included $3.1 million in net reimbursements from the French EAP for arimoclomol, $1.3 million of royalties and other reimbursements under the AZSTARYS® License Agreement, and de minimis OLPRUVA revenue via sales to the new specialty pharmacy, Orsini, were offset by returns from the prior pharmacy in Q2 2024. In addition, cost of goods sold was inflated during the quarter due to recognition of a $3.2 million obsolescence reserve against OLPRUVA inventory which is nearing expiration. This excess inventory was ordered prior to our acquisition of Acer, and the delayed launch impacted the rate of usage, leading to the need for this reserve to be recognized in the quarter. Research and development (R&D) expenses were $10.5 million for Q2 2024, compared to $7.4 million in Q2 2023. The increase in R&D expenses was primarily driven by an increase in spending for the KP1077 Phase 2 clinical trial and an increase in personnel-related costs, partially offset by a decrease in third-party costs related to arimoclomol. Selling, general and administrative (SG&A) expenses were $12.6 million for Q2 2024, compared to $6.6 million in Q2 2023. The period-over-period increase reflects the commercial team in place for the entire quarter and actively engaged in activities to build awareness and provide patient services related to OLPRUVA, leading to an increase in personnel costs due to the additional headcount and an increase in other expenses related primarily to the launch of OLPRUVA. Net loss for Q2 2024 was ($19.9) million, or ($0.48) per basic and diluted share, compared to a net loss of ($2.6) million, or ($0.08) per basic and diluted share for Q2 2023. As of June 30, 2024, total cash, cash equivalents, and investments were $49.3 million, a decrease of $3.4 million compared to $52.7 million as of March 31, 2024. The decrease was driven, in part, by increased third-party R&D costs related to the KP1077 clinical development program and increased SG&A expenses during the period as the Company invested in its commercial infrastructure. As of June 30, 2024, total shares of common stock outstanding were 41,991,464, and fully diluted common shares were 57,324,496, which included 5,483,537 shares issuable upon exercise of warrants. On April 5, 2024, the Company announced the refinancing of its existing debt with up to $100 million in committed capital, which strengthened its balance sheet, simplified its debt structure, and provided non-dilutive capital flexibility. The refinancing was led by Perceptive Advisors and HealthCare Royalty Partners, premier biotech investors. From the initial draw of $60 million at closing, the Company refinanced its existing debt of $43 million and added an incremental $14 million in net cash proceeds to the cash balance after fees and discounts. A second tranche of up to $20 million is available at the Company’s discretion until October 5, 2025, and a third tranche of up to $20 million will become available upon approval of arimoclomol, in each case subject to certain terms and conditions. On August 12, 2024, the Company completed an underwritten public offering, further strengthening its balance sheet. The underwriters fully exercised their overallotment option, resulting in the issuance of approximately 10.6 million shares at a price of $6.50 per share, raising net proceeds of $64.5 million after fees and expenses. Combining the net proceeds from this offering with our existing resources, pro forma June 30, 2024 total cash, cash equivalents and investments was $113.8 million. Following the closing of the underwritten public offering on August 12, 2024, pro forma June 30, 2024, common shares and fully diluted shares outstanding were 52,606,849 and 67,939,881, respectively. No warrants were issued as part of the underwritten public offering. Based on our current operating plan, available cash, cash equivalents, and investments, including proceeds from the underwritten offering closed in August, are expected to extend our cash runway into the first quarter of 2027, subject to continuing compliance with our debt covenants. Cash runway forecast includes: revenue from the expected sales of OLPRUVA, ongoing reimbursements from the French EAP for arimoclomol, ongoing royalties under the AZSTARYS license agreement, and investments into the incremental commercial activities needed to support the launch of arimoclomol, if approved. Cash runway forecast does not include commercial revenue from arimoclomol which could follow a potential FDA approval or the potential sale of the Priority Review Voucher which would be received upon approval. Conference Call Information Zevra will host a conference call and audio webcast today at 4:30 p.m. ET, to discuss its corporate and financial results for Q2 2024. The audio webcast will be accessible via the Investor Relations section of the Company’s website, http://investors.zevra.com/. An archive of the audio webcast will be available for ninety (90) days beginning at approximately 5:30 p.m. ET, on August 13, 2024. Additionally, interested participants and investors may access the conference call by dialing either: (800) 225-9448 (United States)+1 (203) 518- 9708 (International)Conference ID: ZVRAQ224 About Urea Cycle Disorders UCDs are a group of rare, genetic disorders that can cause harmful ammonia to build up in the blood, potentially resulting in brain damage and neurocognitive impairments if ammonia levels are not controlled.i Any increase in ammonia over time is serious. Therefore, it is important to adhere to any dietary protein restrictions and have alternative medication options to help control ammonia levels. About OLPRUVA® OLPRUVA (sodium phenylbutyrate) was approved for the treatment of certain UCDs in December 2022 and has recently been marketed under the brand name, OLPRUVA®. OLPRUVA (sodium phenylbutyrate) for oral suspension is a prescription medicine used along with certain therapies, including changes in diet, for the long-term management of adults and children weighing 44 pounds (20 kg) or greater and with a body surface area (BSA) of 1.2 m2 or greater, with UCDs, involving deficiencies of carbamylphosphate synthetase (CPS), ornithine transcarbamylase (OTC), or argininosuccinic acid synthetase (AS). OLPRUVA is not used to treat rapid increase of ammonia in the blood (acute hyperammonemia), which can be life-threatening and requires emergency medical treatment. For more information, please visit www.OLPRUVA.com. Important Safety Information Certain medicines may increase the level of ammonia in your blood or cause serious side effects when taken during treatment with OLPRUVA. Tell your doctor about all the medicines you or your child take, especially if you or your child take corticosteroids, valproic acid, haloperidol, and/or probenecid. OLPRUVA can cause serious side effects, including: 1) nervous system problems (neurotoxicity). Symptoms include sleepiness, tiredness, lightheadedness, vomiting, nausea, headache, confusion, 2) low potassium levels in your blood (hypokalemia) and 3) conditions related to swelling (edema). OLPRUVA contains salt (sodium), which can cause swelling from salt and water retention. Tell your doctor right away if you or your child get any of these symptoms. Your doctor may do certain blood tests to check for side effects during treatment with OLPRUVA. If you have certain medical conditions such as heart, liver or kidney problems, are pregnant/planning to get pregnant or breast-feeding, your doctor will decide if OLPRUVA is right for you. The most common side effects of OLPRUVA include absent or irregular menstrual periods, decreased appetite, body odor, bad taste or avoiding foods you ate prior to getting sick (taste aversion). These are not all of the possible side effects of OLPRUVA. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. About Niemann-Pick Disease Type C (NPC) Niemann-Pick disease type C (NPC) is an ultra-rare, progressive, and neurodegenerative lysosomal storage disorder characterized by an inability of the body to transport cholesterol and other lipids within the cell, leading to an accumulation of these substances in various tissue areas, including brain tissue. The disease is caused by mutations in the NPC1 or NPC2 genes, which are responsible for making lysosomal proteins. Both children and adults can be affected by NPC with varying clinical presentations. Those living with NPC lose independence due to physical and cognitive limitations, with key neurological impairments presenting in speech, cognition, swallowing, ambulation, and fine motor skills. Disease progression is irreversible and can be fatal within months or take years to be diagnosed and advance in severity. About Arimoclomol Arimoclomol, Zevra’s orally-delivered, investigational drug product candidate for the treatment of NPC, has been granted Orphan Drug designation, Fast Track designation, Breakthrough Therapy designation, and Rare Pediatric Disease designation by the FDA, and Orphan Medicinal Product designation for the treatment of NPC by the European Medicines Agency (EMA). The FDA has accepted the resubmission of the NDA for arimoclomol and has set a user fee action date (PDUFA date) of September 21, 2024. About Idiopathic Hypersomnia (IH) Idiopathic hypersomnia (IH) is a rare sleep disorder characterized by excessive daytime sleepiness (EDS). Patients with IH experience daytime lapses into sleep, or an irrepressible need to sleep that persists even with adequate or prolonged nighttime sleep. Additionally, those with IH have extreme difficulty waking, otherwise known as sleep inertia, severe brain fog, and often fall asleep unintentionally or at inappropriate times. These symptoms of IH often lead to further, even more debilitating problems such as memory lapses, difficulty maintaining focus, and depression. It is estimated, based on claims data, that approximately 37,000 patients in the United States are currently diagnosed with IH, although the total patient population may be much larger due to some patients who have not yet been diagnosed, have been misdiagnosed, or are not currently seeking treatment. About KP1077 KP1077 (serdexmethylphenidate, or SDX) is Zevra’s proprietary prodrug of d-methylphenidate (d-MPH) and its sole active pharmaceutical ingredient (API). KP1077 has been granted Orphan Drug Designation by the FDA, and by the European Commission, for the treatment of IH. The U.S. Drug Enforcement Agency (DEA) has classified SDX, the sole API in KP1077, as a Schedule IV controlled substance based on evidence suggesting SDX has a lower potential for abuse when compared to d-MPH, a Schedule II controlled substance. In addition, KP1077 has intellectual property protection though 2037 and potentially beyond. About Celiprolol Celiprolol is an investigational clinical candidate for the treatment of Vascular Ehlers-Danlos Syndrome (VEDS). Celiprolol has been granted Orphan Drug and Breakthrough Therapy Designations by the FDA. Zevra recently restarted enrollment in the Phase 3 trial, known as the DiSCOVER trial being conducted under a Special Protocol Assessment (SPA) agreement with the FDA. Celiprolol’s mechanism of action is designed to reduce the mechanical stress on collagen fibers within the arterial wall through vascular dilation and smooth muscle relaxation. About Vascular Ehlers-Danlos Syndrome Vascular Ehlers-Danlos syndrome is a rare genetic cardiovascular disorder which impairs collagen 3 rich connective tissue and leads to vascular and hollow organ ruptures. It is estimated that approximately 7,500 patients in the United States are currently diagnosed patients with VEDS. There remains an unmet need with no approved treatment in the United States. Celiprolol is currently the standard of care in Europe. About Zevra Therapeutics Zevra Therapeutics is a rare disease company combining science, data, and patient needs to create transformational therapies for diseases with limited or no treatment options. Our mission is to bring life-changing therapeutics to people living with rare diseases. With unique, data-driven development and commercialization strategies, the Company is overcoming complex drug development challenges to make new therapies available to the rare disease community. For more information, please visit www.zevra.com or follow us on X and LinkedIn. Cautionary Note Concerning Forward-Looking Statements This press release may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include all statements that do not relate solely to historical or current facts, including without limitation statements regarding the promise and potential impact of our preclinical or clinical trial data; the initiation, timing and results of any clinical trials or readouts, the content, information used for, timing or results of any NDA submissions or resubmissions for arimoclomol or any other product candidates for any specific disease indication or at any dosage; the potential benefits of any of our products or product candidates for any specific disease or at any dosage; the impact of meetings or communications with the FDA or any advisory committee; decisions by the FDA or any other entity for arimoclomol or any other product candidates; our strategic and product development objectives, including with respect to becoming a leading, commercially focused rare disease company; the potential benefits of our debt facility;, our our financial position, including our cash balance: our corporate governance objectives; potential revenues from our arimoclomol expanded access program; the potential for royalty and milestone contributions, the presentation of data at conferences; and the timing of any of the foregoing. Forward-looking statements are based on information currently available to Zevra and its current plans or expectations. They are subject to several known and unknown uncertainties, risks, and other important factors that may cause our actual results, performance, or achievements to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. These and other important factors are described in detail in the “Risk Factors” section of Zevra’s Annual Report on Form 10-K for the year ended December 31, 2023, Zevra’s Quarterly Report on Form 10-Q for the three months ended June 30, 2024, and Zevra’s other filings with the Securities and Exchange Commission. While we may elect to update such forward-looking statements at some point in the future, except as required by law, we disclaim any obligation to do so, even if subsequent events cause our views to change. Although we believe the expectations reflected in such forward-looking statements are reasonable, we cannot assure that such expectations will prove correct. These forward-looking statements should not be relied upon as representing our views as of any date after the date of this press release. ________________________i Ah Mew N, et al. Urea cycle disorders overview [updated June 22, 2017]. In: Adam MP, Ardinger HH, Pagon RA, et al, eds. GeneReviews® [Internet]. University of Washington; 1993-2022. Accessed March 20, 2022. Zevra Contact Nichol Ochsner+1 (732) 754-2545nochsner@zevra.com Russo Partners Contacts Adanna G. Alexander, Ph.D.+1 (646) 942-5603adanna.alexander@russopartnersllc.com ZEVRA THERAPEUTICS, INC. UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (in thousands, except share and per share amounts) Three months endedJune 30, Six months endedJune 30, 2024 2023 2024 2023Revenue, net $4,449 $8,470 $7,874 $11,646 Cost of product revenue (excluding $1,546 and $3,074 in intangible asset amortization for the three and six months ended June 30, 2024, respectively shown separately below) 3,573 677 3,748 802 Intangible asset amortization 1,546 — 3,074 — Operating expenses: Research and development 10,521 7,433 22,798 16,088 Selling, general and administrative 12,604 6,612 22,535 13,839 Total operating expenses 23,125 14,045 45,333 29,927 Loss from operations (23,795) (6,252) (44,281) (19,083)Other income (expense): Interest expense (2,110) (197) (2,845) (379)Fair value adjustment related to warrant and CVR liability 5,779 2,118 9,406 575 Fair value adjustment related to investments 1 131 (26) 327 Interest and other income (expense), net 270 1,553 1,199 2,593 Total other income 3,940 3,605 7,734 3,116 Loss before income taxes (19,855) (2,647) (36,547) (15,967)Income tax benefit (70) 74 — 177 Net loss $(19,925) $(2,573) $(36,547) $(15,790) Basic and diluted net loss per share of common stock: Net loss $(0.48) $(0.08) $(0.87) $(0.46)Weighted average number of shares of common stock outstanding: Basic and diluted 41,899,087 33,898,233 41,839,582 34,180,818 ZEVRA THERAPEUTICS, INC. UNAUDITED CONDENSED CONSOLIDATED BALANCE SHEETS (in thousands, except share and par value amounts) June 30, December 31, 2024 2023Assets Current assets: Cash and cash equivalents $39,260 $43,049 Securities at fair value 9,998 24,688 Accounts and other receivables 8,947 17,377 Prepaid expenses and other current assets 2,686 1,824 Total current assets 60,891 86,938 Inventories 10,198 9,841 Property and equipment, net 678 736 Operating lease right-of-use assets 911 790 Goodwill 4,701 4,701 Intangible assets, net 66,154 69,227 Other long-term assets 875 94 Total assets $144,408 $172,327 Liabilities and stockholders' equity Current liabilities: Accounts payable and accrued expenses $20,452 $28,403 Line of credit payable — 37,700 Current portion of operating lease liabilities 596 543 Current portion of discount and rebate liabilities 6,768 4,550 Other current liabilities 2,633 2,524 Total current liabilities 30,449 73,720 Long-term debt 58,328 5,066 Warrant liability 7,856 16,100 Operating lease liabilities, less current portion 544 456 Discount and rebate liabilities, less current portion 8,115 7,663 Other long-term liabilities 6,638 7,458 Total liabilities 111,930 110,463 Commitments and contingencies Stockholders’ equity: Preferred stock: Undesignated preferred stock, $0.0001 par value, 10,000,000 shares authorized, no shares issued or outstanding as of June 30, 2024, or December 31, 2023 — — Common stock, $0.0001 par value, 250,000,000 shares authorized, 43,567,156 shares issued and 41,991,464 shares outstanding as of June 30, 2024; 43,110,360 shares issued and 41,534,668 shares outstanding as of December 31, 2023 4 4 Additional paid-in capital 479,361 472,664 Treasury stock, at cost (10,983) (10,983)Accumulated deficit (436,325) (399,778)Accumulated other comprehensive income (loss) 421 (43)Total stockholders' equity 32,478 61,864 Total liabilities and stockholders' equity $144,408 $172,327

DUBAI, UAE, May 16, 2024 /PRNewswire/ -- XRP Healthcare proudly announces its sponsorship of the upcoming Ehlers-Danlos Society event in Philadelphia this July 17th – 21st. Dedicated to raising awareness and support for individuals living with any of the types of Ehlers-Danlos syndrome (EDS) or hypermobility spectrum disorders (HSD), this event will be a beacon of hope and solidarity for the EDS and HSD community. Continue Reading XRP Healthcare Sponsors The Ehlers-Danlos Society, with Vital Support via its Prescription Savings Card EDS and HSD are a group of heritable connective tissue disorders characterized by joint hypermobility, widespread musculoskeletal pain, multiple other concerns termed comorbidities, and, in EDS, fragile body tissues that more easily scar, tear or rupture. Managing EDS and HSD often involves a complex treatment regimen, including prescription medications to alleviate pain and other associated conditions. As part of its commitment to improving healthcare accessibility and affordability, XRP Healthcare introduced the XRP Healthcare prescription savings card last year. Now seamlessly integrated into the XRPH App/wallet and available to download on Google Play and iOS store, this innovative solution empowers individuals with EDS or HSD to access their prescribed medications at significantly reduced costs – with the added benefit of being paid $1.00 of XRPH tokens each time they use the card. The XRP Healthcare Prescription Savings Card offers savings of up to 80% off prescriptions and medications essential for managing EDS and HSD, including pain relievers, muscle relaxants, topical creams and patches, and gastrointestinal medications. With access to over 68,000 pharmacies in the USA, including Walmart, CVS Pharmacy, and Walgreens, individuals diagnosed with EDS or HSD can now enjoy substantial savings on their necessary treatments. "We are thrilled to support the EDS and HSD community through our sponsorship of this important charity event," said Kain Roomes, CEO and founder of XRP Healthcare. "At XRP Healthcare, we believe that everyone deserves access to affordable healthcare solutions. Our prescription savings card has the potential to save individuals with EDS or HSD hundreds of dollars annually, ensuring they can afford the medications they need to manage their condition effectively." As part of the sponsorship, the event will feature a special presentation by the Ehlers-Danlos Society, including an interview with Lara Bloom, President and CEO of the society in the next issue of the XRP Healthcare magazine – physical copies will be available for attendees at the event, as well as from chosen locations throughout Africa, America, United Kingdom and Europe. Professor Bloom has been a tireless advocate for individuals living with EDS and HSD, and her insights will provide invaluable support and inspiration to attendees. "I am deeply grateful to XRP Healthcare for their generous support of our charity event," said Lara Bloom. "Their dedication to improving access to affordable healthcare aligns perfectly with our mission to empower individuals living with EDS or HSD. Together, we can make a meaningful difference in the lives of those affected by this challenging condition." The Ehlers-Danlos Society event in Philadelphia promises to be a transformative gathering, uniting individuals, healthcare professionals, and advocates in the shared goal of raising awareness and support for EDS and HSD. Through initiatives like the XRP Healthcare prescription savings card, the EDS and HSD community can look forward to brighter and more accessible healthcare futures. About XRP Healthcare: XRP Healthcare is the first Pharma and Healthcare platform on the XRP Ledger, enabling fast global payments, improving healthcare access in emerging markets, and creating real-world utility by transforming global healthcare through mergers, acquisitions and blockchain. About the Ehlers-Danlos Society: The Ehlers-Danlos Society is a global community of patients, caregivers, healthcare professionals, and advocates dedicated to advancing research, education, and support for individuals living with Ehlers-Danlos syndrome (EDS) or hypermobility spectrum disorder (HSD) and related disorders and is based in New York, USA. Photo - Logo - SOURCE XRP Healthcare