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Last update 08 May 2025

Lichen Nitidus

Last update 08 May 2025

Basic Info

Synonyms

Lichen Nitidus, Lichen nitidus, Lichen nitidus (disorder)

+ [14]

Introduction

A chronic inflammatory disease characterized by shiny, flat-topped, usually flesh-colored micropapules no larger than the head of a pin. Lesions are localized in the early stages, found chiefly on the lower abdomen, penis, and inner surface of the thighs. Distribution may become generalized as the disease progresses.

Drugs associated with Lichen Nitidus

Flurandrenolide

Target

Mechanism

GR agonists

Active Org.

Sumitomo Pharma Co., Ltd.

Originator Org.

Almirall SA

Active Indication

Amyloidosis, Primary Cutaneous [+14]

Inactive Indication

Inflammation [+1]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

United States

First Approval Date19 Mar 1963

CN115477611

Patent Mining

Target

MRGPRX2

Mechanism-

Active Org.

The University of Hong Kong

Originator Org.

The University of Hong Kong

Active Indication

Immune System Diseases [+2]

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

US20240376092

Patent Mining

Target

PRNP

Mechanism-

Active Org.

Università degli Studi di Perugia

Originator Org.

Università degli Studi di Perugia

Active Indication

Immune System Diseases [+2]

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with Lichen Nitidus

100 Translational Medicine associated with Lichen Nitidus

0 Patents (Medical) associated with Lichen Nitidus

426

Literatures (Medical) associated with Lichen Nitidus

01 Aug 2025·Current Pediatric Reviews

Lichen Striatus: An Updated Review

Article

Author: Barankin, Benjamin ; Leong, Kin Fon ; Leung, Alexander K.C. ; Lam, Joseph M.

Background::Lichen striatus is a benign dermatosis that affects mainly children. This condition mimics many other dermatoses.Objective::The purpose of this article is to familiarize pediatricians with the clinical manifestations of lichen striatus to avoid misdiagnosis, unnecessary investigations, unnecessary referrals, and mismanagement of lichen striatus.Methods::A search was conducted in June 2023 in PubMed Clinical Queries using the key term “Lichen striatus”. The search strategy included all observational studies, clinical trials, and reviews published within the past ten years. Only papers published in the English literature were included in this review. The information retrieved from the above search was used in the compilation of this article.Results::Lichen striatus is a benign self-limited T-cell mediated dermatosis characterized by a linear inflammatory papular eruption seen primarily in children. The onset is usually sudden with minimal or absent symptomatology. The eruption in typical lichen striatus consists of discrete, skin- colored, pink, erythematous, or violaceous, flat-topped, slightly elevated, smooth or scaly papules that coalesce to form a dull red, potentially scaly, interrupted or continuous band over days to weeks. Although any part of the body may be involved, the extremities are the sites of predilection. Typically, the rash is solitary, unilateral, and follows Blaschko lines. In dark-skinned individuals, the skin lesions may be hypopigmented at onset. Nails may be affected alone or, more commonly, along with the skin lesions of lichen striatus. The differential diagnoses of lichen striatus are many and the salient features of other conditions are highlighted in the text.Conclusion::Lichen striatus is a self-limited condition that often resolves within one year without residual scarring but may have transient post-inflammatory hypopigmentation or hyperpigmentation. As such, treatment may not be necessary. For patients who desire treatment for cosmesis or for the symptomatic treatment of pruritus, a low- to mid-potency topical corticosteroid or a topical immunomodulator can be used. A fading cream can be used for post-inflammatory hyperpigmentation.

01 Feb 2025·The American Journal of Dermatopathology

Postautologous Hematopoietic Stem Cell Transplantation Disseminated Hypopigmented Keratosis

Article

Author: Sripodok, Supasan ; Wu, Nan-Lin ; Wu, Yu-Hung

Abstract:Disseminated hypopigmented keratosis is a rare distinct clinical entity. This report describes the case of a 19-year-old male patient who developed disseminated hypopigmented keratosis 2 months after autologous hematopoietic stem cell transplantation for pineal choriocarcinoma. The patient displayed numerous tiny whitish or depigmented macules and papules on the chest, back, posterior neck, shoulders, arms, and thighs, closely resembling lichen nitidus. Microscopically, the lesion was orthokeratotic, acanthotic, and flat-bottomed without cytological atypia. Dermal inflammation was minimal. Fontana–Masson, Melan-A, and sex-determining region Y-box transcription factor 10 staining revealed a significant decrease in both basal melanin content and the number of melanocytes. The patient was initially administered a topical agent comprising hydrocortisone and urea, which exhibited minimal improvement. This case report suggests that disseminated hypopigmented keratosis may be a rare cutaneous manifestation of autologous hematopoietic stem cell transplantation. Additional research is necessary to gain a more comprehensive understanding of the pathogenesis and the clinical course of this disease.

27 Jan 2025·Clinical and Experimental Dermatology

Erythematous papule over a tattoo

Article

Author: Jiménez-Briones, Luis ; Rodríguez-Sánchez, Belén ; Martín-Nieto González, Jorge ; Avilés-Izquierdo, José Antonio ; Arias-Lotto, Francisco

A 38-year-old man presented with an erythematous papule over a longstanding back tattoo. Dermoscopy, which is very useful in the differential diagnosis of dermatological lesions, shows shiny white lines indicating a fibrotic stroma and various vascular patterns. The presence of a fenestrated histological pattern confirms the diagnosis. Surgical excision is the treatment of choice.

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Lichen Nitidus

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