Last update 01 Nov 2024

HER2 Positive Adenocarcinoma of Esophagus

Basic Info

Synonyms
HER2 Positive Esophageal Adenocarcinoma
Introduction-

Related

2
Drugs associated with HER2 Positive Adenocarcinoma of Esophagus
Neratinib maleate
Target
EGFR x HER2 x HER4
Mechanism
EGFR antagonists [+2]
Active Org.
Convalife (Shanghai) Co. Ltd.Convalife (Shanghai) Co. Ltd. [+10]
Originator Org.
Pfizer Inc.Pfizer Inc.
Active Indication
Early Stage Breast Carcinoma [+25]
Inactive Indication
Advanced HER2-Positive Breast Carcinoma [+11]
Drug Highest PhaseApproved
First Approval Ctry. / Loc.
US
First Approval Date17 Jul 2017
Zongertinib
Target
HER2
Mechanism
HER2 antagonists
Active Org.
Boehringer Ingelheim International GmbH [+3]
Originator Org.
Boehringer Ingelheim International GmbH
Active Indication
HER2 mutant non-small cell lung cancer [+14]
Inactive Indication-
Drug Highest PhasePhase 3
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
2
Clinical Trials associated with HER2 Positive Adenocarcinoma of Esophagus
CTR20242277 / Not yet recruitingPhase 1/2
Beamion BCGC-1：一项评价口服zongertinib（BI 1810631）联合德曲妥珠单抗（T-DXd）静脉给药或联合恩美曲妥珠单抗（T-DM1）静脉给药用于治疗晚期HER2+转移性乳腺癌（mBC）和转移性胃癌、食管胃结合部癌或食管腺癌（mGEAC）患者的Ib期剂量递增和II期剂量优化、随机、开放性、多中心临床研究
[Translation] Beamion BCGC-1: A Phase Ib dose-escalation and Phase II dose-optimization, randomized, open-label, multicenter study evaluating oral zongertinib (BI 1810631) in combination with intravenous trastuzumab dexmedetomidine (T-DXd) or intravenous trastuzumab emtansine (T-DM1) in patients with advanced HER2+ metastatic breast cancer (mBC) and metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma (mGEAC)
NCT06374888 / Not yet recruitingPhase 2
A Single-arm, Open, Multicenter Phase II Clinical Study of Nilatinib Maleate Tablets Combined With Capecitabine in the Treatment of HER2-positive Advanced Esophageal/Esophagogastric Junction/Gastric Adenocarcinoma With Brain Metastases
100 Clinical Results associated with HER2 Positive Adenocarcinoma of Esophagus
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100 Translational Medicine associated with HER2 Positive Adenocarcinoma of Esophagus
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0 Patents (Medical) associated with HER2 Positive Adenocarcinoma of Esophagus
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