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Last update 08 May 2025

Granulomatous Mastitis

Last update 08 May 2025

Basic Info

Synonyms

Granulomatis mastitis, Granulomatous Mastitis, Granulomatous mastitis

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Introduction

A rare, benign, inflammatory breast disease occurring in premenopausal women shortly after a recent pregnancy. The origin is unknown but it is commonly mistaken for malignancy and sometimes associated with BREAST FEEDING and the use of ORAL CONTRACEPTIVES.

Clinical Trials associated with Granulomatous Mastitis

NCT06943482

/ Not yet recruitingPhase 4IIT

A Pilot Open-label Randomised Trial Comparing the Effectiveness of Steroids and Methotrexate for the Treatment of Idiopathic Granulomatous Mastitis

This research study is to determine the effectiveness of prednisolone and methotrexate for IGM patients over a period of one year, in terms of clinical and radiological response. Recruitment will be conducted in National University Hospital (NUH) for patients diagnosed with IGM.

Start Date01 Jul 2025

Sponsor / Collaborator

National University Hospital

NCT06712524

/ RecruitingNot ApplicableIIT

A Prospective Real-world Study of the Effect of Different Surgical Approaches on the Recurrence Rate and Aesthetic Outcome of Granulomatous Mastitis

The objective of this study was to prospectively investigate the effects of different surgical approaches on the recurrence rate and aesthetic outcome of patients with granulomatous mastitis. The patients were divided into traditional surgery group and plastic surgery group.

Start Date01 Nov 2024

Sponsor / Collaborator

Hubei Cancer Hospital

NCT06665399

/ RecruitingNot ApplicableIIT

Observation Alone for Mild Non-Lactational Mastitis: a Cohort Study.

The goal of this observational study is to investigate the disease progression rate and timing in patients with mild Non-Lactational Granulomatous Lobular / Periductal Mastitis (NL-GLM/PDM) during follow-up with observation alone strategy. The main questions it aims to answer are: What is the rate of disease progression in mild NL-GLM/PDM patients under observation, and what clinical and pathological factors are associated with this progression? Participants with diagnosis of mild NL-GLM/PDM will be monitored over a specified period, with data collected on their clinical outcomes and relevant factors influencing disease progression.

Start Date11 Sep 2024

Sponsor / Collaborator

Sun Yat-Sen University

100 Clinical Results associated with Granulomatous Mastitis

100 Translational Medicine associated with Granulomatous Mastitis

0 Patents (Medical) associated with Granulomatous Mastitis

1,408

Literatures (Medical) associated with Granulomatous Mastitis

01 Dec 2025·European Journal of Trauma and Emergency Surgery

Study of bone-tendon interface healing in an animal model using a synthetic scaffold and PRP

Article

Author: Llorens Martínez, Xavier ; Engel, Elisabeth ; Mora Guix, J M ; Ruiz Macarrilla, Leonardo ; Mateos-Timoneda, Miguel A ; Rey-Viñolas, Sergi

PURPOSEBiological matrices have been used to reinforce large rotator cuff tear repairs. However, rapid resorption and initial immune reactions presented challenges in clinical practice. This study evaluates whether a resorbable synthetic matrix (scaffold), used alone or with platelet-rich plasma (PRP), impacts repair processes at microscopic, ultrasound, and biomechanical levels in a rabbit model of induced tendon-bone interface injury.METHODSAn experimental study was performed on 24 rabbits. Two experimental groups (n = 12 each) and a control group (n = 24) were defined. In the first group (BioP), the internal gastrocnemius tendon was sectioned and repaired to bone using double-row sutures, reinforced with a PLC (poly-L-lactic-co-ε-caprolactone) and PLA (polylactic acid) scaffold. In the second group (BioP + PRP), autologous PRP was added to the repair. The control group received no scaffold or PRP. Euthanasia was performed at 8 weeks, followed by microscopic, ultrasound, and biomechanical evaluations.RESULTSMicroscopically, a granulomatous reaction limited to the foreign body was observed in both scaffold groups. The healing process was not altered in any group, showing good biocompatibility of the scaffold. Echographically, a greater sagittal diameter was observed in the group without PRP compared to the other groups. Biomechanically, no significant differences in rupture zones were found across groups, but the scaffold-only group required a higher maximum applied force before rupture.CONCLUSIONSAt 8 weeks, using a degradable synthetic PLC and PLA scaffold as support at the bone-tendon interface did not significantly alter the normal repair process, showed echographic and biomechanical benefits, and PRP did not show additional benefits in our experimental model.

01 May 2025·Academic Radiology

Analysis of the Clinical Characteristics and Ultrasonographic Features in 141 Cases of Cystic Neutrophilic Granulomatous Mastitis

Article

Author: Zhang, Dongxiao ; Wang, Mengjie ; Liu, Yongxin ; Wang, Yating ; Zhang, Hongkai ; Liu, Min ; Fu, Na

RATIONALE AND OBJECTIVESTo summarize the clinical features and ultrasonic characteristics of patients with cystic neutrophilic granulomatous mastitis (CNGM), and to enhance the understanding of CNGM in clinical practice.MATERIALS AND METHODSThis study retrospectively analyzed the demographic data, clinical symptoms, and ultrasonic characteristics of 141 patients diagnosed with CNGM through pathological examination. This study was approved by the Medical Ethical Committee of Beijing Hospital of Traditional Chinese Medicine (2023BL02-054-01).RESULTSCNGM is more common in women of childbearing age. Clinically, the majority of CNGM patients presented with breast lumps, redness, swelling, ulceration, nipple discharge, and nipple retraction. Some patients also exhibited systemic symptoms such as erythema nodosum, fever, and cough. Ultrasonically, CNGM was characterized by irregular, hypoechoic areas with unclear margins. Additional features included liquefaction areas within the hypoechoic areas, subcutaneous extension, tissue thickening, ductal dilatation, and axillary lymph node enlargement. Among the 141 cases, CNGM patients were classified into four types based on the nature and extent of the lesions: 87 cases of diffuse abscess type, 49 cases of patchy hypoechoic type, 2 cases of localized hypoechoic type, and 3 cases of localized abscess type.CONCLUSIONThis study describes the clinical features, ultrasound manifestations and their various subtypes, and microbial identification of patients with CNGM, which will help to better identify CNGM as a potential diagnostic entity with important implications for subsequent treatment.DATA AVAILABILITY STATEMENTThe original contributions presented in the study are included in the article. Further inquiries can be directed to the corresponding authors.

01 May 2025·Annales de Chirurgie Plastique Esthétique

Granulomatous mastitis a little known pathology in plastic surgery: Case report and literature review

Review

Author: López, J ; Menéndez, R ; Morales, C ; Cálix, M ; Sánchez, L

Granulomatous mastitis is an unknown disease for the plastic surgeon, it is frequent, benign and can be confused with an infectious process and its importance lies in the fact that it can occur after surgery. Its diagnosis is clinical, presenting an indurated region in the breast, which can progress to abscesses or crypts, as well as radiological and histological. We present the case of a 57-year-old patient who presented with a lesion 1 month after a reduction mammoplasty. Conservative treatment was carried out with the possibility of fat necrosis and due to persistence, granulomatous mastitis was confirmed by biopsy after 6 months of evolution. This article establishes a diagnostic and treatment protocol based on the latest recommendations in the literature, oriented towards plastic surgery, starting with oral steroids in long courses, and immunomodulators may be used for resistant cases, including excisional surgical management. In the case of abscesses or crypts, treatment of the concomitant infection should be given.

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