Aggressive Non-Hodgkin Lymphoma

THURSDAY, July 25, 2024 -- Farmers and folks living in agricultural areas may be exposed to levels of pesticides that confer cancer risks that are higher than if they smoked, new research shows. These extra risks were most pronounced for certain cancers: non-Hopkins lymphoma, leukemia and bladder cancer, the researchers noted. Various pesticides mix together to raise the odds for cancer, noted study lead author Isain Zapata . "It is the combination of all of them, and not just a single one, that matters,” said Zapata, who is an associate professor at Rocky Vista University's College of Osteopathic Medicine in Colorado. His team published its findings July 25 in the journal Frontiers in Cancer Control and Society . “In the real world, it is not likely that people are exposed to a single pesticide, but more to a cocktail of pesticides within their region,” explained Zapata, so the new analysis tracked exposures to 69 common pesticides, based on usage data from the United States Geological Survey. The research team's modeling created estimates of cancer risk. They revealed that for people regularly exposed, the lifetime risk of getting non-Hopkins lymphoma, leukemia and bladder cancer was greater from pesticides than if they had been smokers. Speaking in a journal news release, Isain explained that "it is difficult to explain the magnitude of an issue without presenting any context, so we incorporated smoking data." “We were surprised to see [risk] estimates in similar ranges,” Zapata said. Geography mattered, too: Not surprisingly, pesticide-linked cancer risks were highest in agriculturally rich areas of the United States, such as the Midwest. The next time you pick up an ear of corn or a tomato at the supermarket, consider the source and the risks involved to workers, Zapata said. “Every time I go to the supermarket to buy food, I think of a farmer who was part of making that product," he said. "These people often put themselves at risk for my convenience and that plays a role in my appreciation for that product. It definitely has had an impact on how I feel when that forgotten tomato in the fridge goes bad and I have to put it in the trash." Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

HANGZHOU, China I July 18, 2023 I Hangzhou Qihan Biotech Co., Ltd. ("Qihan" or "Qihan Biotech" or "the Company"), an industry leader in applying multiplexable genome editing technology to cell therapies and organ transplantation, announced today that the National Medical Products Administration (NMPA) approved its clinical trial application for the product QN-019a. It is the first IND approved in China for a gene-edited iPSC-derived cell therapy product. Qihan Biotech utilizes multiplexable genome editing technology to modify human Induced Pluripotent Stem Cells (iPSCs) and differentiate them into natural killer (NK) cell therapy product QN-019a, targeting CD19-positive B-cell lymphoma. The clinical indication for QN-019a is CD19-positive relapsed/refractory aggressive B-cell non-Hodgkin lymphoma. According to the official website of the Center for Drug Evaluation, NMPA, the clinical trial application for QN-019a cell injection has received approval as of July 18, 2023. "The approval of our application for the clinical trial is a result of our team's collaborative efforts and also signifies Qihan entering a new phase in its evolution. The IND approval is the first step in a long drug development journey, and we will adhere to scientific rigor and fully use our genome editing technology and in-depth biological knowledge to continue our research," said Dr. Luhan Yang, the founder and CEO of Qihan Biotech. "We look forward to developing Off-the-Shelf cell therapy products with long-term efficacy for patients and realizing the vision of Qihan.” About Qihan Biotech Qihan Biotech is a biotechnology company applying genome editing technology to develop novel cell therapies and organs for transplantation. The company's mission is to use high-throughput, multiplexable genome editing combined with expertise in transplantation immunology to create immunologically privileged allogeneic cells and xenogeneic organs for use as therapies to treat cancer, organ failure, and other complex medical conditions. With a vision to create a world in which cell and organ therapies are universally available to patients, Qihan Biotech has raised two rounds of financing and has multiple products at different stages of development, including QN-019a. Qihan’s deep scientific experience and technology advancements have enabled the company to create cutting-edge cell therapy products. Qihan Biotech is headquartered in Hangzhou, China. For more information, please visit the company's website at www.qihanbio.com . SOURCE: Qihan Biotech

HANGZHOU, China--(BUSINESS WIRE)-- Hangzhou Qihan Biotech Co., Ltd. ("Qihan" or "Qihan Biotech" or "the Company"), an industry leader in applying multiplexable genome editing technology to cell therapies and organ transplantation, announced today that the National Medical Products Administration (NMPA) approved its clinical trial application for the product QN-019a. It is the first IND approved in China for a gene-edited iPSC-derived cell therapy product. Qihan Biotech utilizes multiplexable genome editing technology to modify human Induced Pluripotent Stem Cells (iPSCs) and differentiate them into natural killer (NK) cell therapy product QN-019a, targeting CD19-positive B-cell lymphoma. The clinical indication for QN-019a is CD19-positive relapsed/refractory aggressive B-cell non-Hodgkin lymphoma. According to the official website of the Center for Drug Evaluation, NMPA, the clinical trial application for QN-019a cell injection has received approval as of July 18, 2023. "The approval of our application for the clinical trial is a result of our team's collaborative efforts and also signifies Qihan entering a new phase in its evolution. The IND approval is the first step in a long drug development journey, and we will adhere to scientific rigor and fully use our genome editing technology and in-depth biological knowledge to continue our research," said Dr. Luhan Yang, the founder and CEO of Qihan Biotech. "We look forward to developing Off-the-Shelf cell therapy products with long-term efficacy for patients and realizing the vision of Qihan.” About Qihan Biotech Qihan Biotech is a biotechnology company applying genome editing technology to develop novel cell therapies and organs for transplantation. The company's mission is to use high-throughput, multiplexable genome editing combined with expertise in transplantation immunology to create immunologically privileged allogeneic cells and xenogeneic organs for use as therapies to treat cancer, organ failure, and other complex medical conditions. With a vision to create a world in which cell and organ therapies are universally available to patients, Qihan Biotech has raised two rounds of financing and has multiple products at different stages of development, including QN-019a. Qihan’s deep scientific experience and technology advancements have enabled the company to create cutting-edge cell therapy products. Qihan Biotech is headquartered in Hangzhou, China. For more information, please visit the company's website at . Forward-looking Statements This release contains statements including, but not limited to, Qihan’s research development and/or relevant programs, its past, ongoing, and planned research studies, and the potential of Qihan’s research candidate. These and any other statements in this release are based on Qihan management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such statements. These risks and uncertainties include, but are not limited to, the risk that Qihan’s research program may not warrant further development, the risk that results observed in prior studies of Qihan’s research candidates will not be observed in ongoing or future studies involving these candidates, the risk of a delay or difficulties in the developing or transforming of Qihan’s research candidates, the risk that Qihan may cease or delay the research development of any of its candidates for a variety of reasons. Qihan is providing the information in this release as of this date and does not undertake any obligation to update any statements contained in this release as a result of new information, future events, or otherwise. Information concerning therapies and related products contained herein is not intended as medical advice.