Atrichia With Papular Lesions

-- On track to complete enrollment of 190 patients in 4Q 2023, with pivotal complete response (CR) data from SELECT-MDS-1 expected in 3Q 2024 -- -- Amended SELECT-MDS-1 study to add overall survival as key secondary endpoint -- -- Initial data from the randomized portion of SELECT-AML-1 trial expected in 4Q 2023 -- -- Management to host conference call at 8:30 a.m. ET today -- CAMBRIDGE, Mass.--(BUSINESS WIRE)-- Syros Pharmaceuticals (NASDAQ:SYRS), a biopharmaceutical company committed to advancing new standards of care for the frontline treatment of hematologic malignancies, today reported financial results for the quarter ended March 31, 2023 and provided a corporate update. “In 2023, we are focusing on clinical execution, with the goal of delivering tamibarotene and SY-2101 as new standards of care for the frontline treatment of hematologic malignancies,” said Nancy Simonian, M.D., Chief Executive Officer of Syros. “We are pleased that recent feedback from the FDA on our SELECT-MDS-1 trial continues to support the CR rate as an appropriate primary endpoint for either full or accelerated approval with supporting data on the durability of remission. We have amended our existing trial to add overall survival as a key secondary endpoint, allowing this single trial to efficiently serve as a confirmatory study if needed for full approval.” Dr. Simonian continued, “In addition, we commenced the randomized portion of the SELECT-AML-1 Phase 2 trial and remain on track to report initial data in the fourth quarter, as well as to provide an update on the development path for SY-2101 in APL in the second half of this year. We are fortunate to operate from a robust financial position, with sufficient capital to fund our efforts into 2025, beyond pivotal CR data from the SELECT-MDS-1 trial and initial data from the randomized portion of SELECT-AML-1.” UPCOMING MILESTONES Tamibarotene: Higher-Risk Myelodysplastic Syndrome (HR-MDS) Complete enrollment of 190 patients necessary to support complete response (CR) primary endpoint in the SELECT-MDS-1 Phase 3 trial in newly diagnosed HR-MDS patients with RARA gene overexpression in the fourth quarter of 2023. Report pivotal CR data from the SELECT-MDS-1 Phase 3 trial in the third quarter of 2024. Tamibarotene: Acute Myeloid Leukemia (AML) Report initial data from the randomized portion of the SELECT-AML-1 Phase 2 trial in newly diagnosed unfit AML patients with RARA overexpression in the fourth quarter of 2023. Report additional data from the SELECT-AML-1 Phase 2 trial in 2024. SY-2101: Acute Promyelocytic Leukemia (APL) Provide an update on the dose confirmation study of SY-2101 and the development path and timing for further evaluation of SY-2101 in a registration-enabling study in APL in the second half of 2023. RECENT PIPELINE HIGHLIGHTS Today, Syros announced that it has amended the protocol for its pivotal Phase 3 SELECT-MDS-1 trial by increasing the number of patients from 190 to 550 to evaluate overall survival (OS) as a key secondary endpoint. This amended study design reflects a more efficient “one-trial” approach and will not affect the timing of our pivotal CR data from SELECT-MDS-1 which is expected in the third quarter of 2024. First Quarter 2023 Financial Results Revenues were $3.0 million for the first quarter of 2023, consisting entirely of revenue recognized under Syros’ collaboration with Pfizer. Syros recognized $5.5 million in revenue in the first quarter of 2022, consisting of $5.1 million in revenue recognized under its collaboration with Pfizer and $0.4 million recognized under its collaboration with Incyte Corporation. Research and development expenses were $28.8 million for the first quarter of 2023, as compared to $25.2 million for the first quarter of 2022. This increase was primarily due to the advancement of the Company’s late-stage clinical programs. General and administrative (G&A) expenses were $7.4 million for the first quarter of 2023, as compared to $6.9 million for the first quarter of 2022. This increase was primarily due to supporting the advancement of our late-stage clinical programs. For the first quarter of 2023, Syros reported a net loss of $23.8 million, or $0.85 per share, compared to a net loss of $25.1 million, or $3.99 per share, for the same period in 2022. Cash and Financial Guidance Cash, cash equivalents and marketable securities as of March 31, 2023 were $166 million, as compared with $202 million on December 31, 2022. Based on its current plans, Syros believes that its existing cash, cash equivalents and marketable securities will be sufficient to fund its anticipated operating expenses and capital expenditure requirements into 2025, beyond pivotal Phase 3 data from the SELECT-MDS-1 trial and initial data from the randomized portion of the SELECT-AML-1 trial. Conference Call and Webcast Syros will host a conference call today at 8:30 a.m. ET to discuss these first quarter 2023 financial results and provide a corporate update. To access the live conference call, please dial (888) 886-7786 (domestic) or (416) 764-8658 (international) and refer to conference ID 19706685. A webcast of the call will also be available on the Investors & Media section of the Syros website at . An archived replay of the webcast will be available for approximately 30 days following the presentation. About Syros Pharmaceuticals Syros is committed to developing new standards of care for the frontline treatment of patients with hematologic malignancies. Driven by the motivation to help patients with blood disorders that have largely eluded other targeted approaches, Syros is advancing a robust late-stage clinical pipeline, including tamibarotene, an oral selective RARα agonist in patients with higher-risk myelodysplastic syndrome and acute myeloid leukemia with RARA gene overexpression, and SY-2101, a novel oral form of arsenic trioxide in patients with acute promyelocytic leukemia. Syros is also seeking partnerships for SY-5609, a highly selective and potent CDK7 inhibitor in clinical development for the treatment of select solid tumors, and multiple preclinical programs in oncology. For more information, visit and follow us on Twitter (@SyrosPharma) and LinkedIn. Cautionary Note Regarding Forward-Looking Statements This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995, including without limitation statements regarding Syros’ clinical development plans, including with respect to the progression of its clinical trials, the timing and impact of enrolling study participants and reporting clinical data, the ability to deliver benefit to patients, and the sufficiency of Syros’ capital resources to fund its operating expenses and capital expenditure requirements into 2025. The words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “hope,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “target,” “should,” “would,” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various important factors, including Syros’ ability to: advance the development of its programs, including tamibarotene and SY-2101, under the timelines it projects in current and future clinical trials; demonstrate in any current and future clinical trials the requisite safety, efficacy and combinability of its drug candidates; sustain the response rates and durability of response seen to date with its drug candidates; successfully develop a companion diagnostic test to identify patients with the RARA biomarker; obtain and maintain patent protection for its drug candidates and the freedom to operate under third party intellectual property; obtain and maintain necessary regulatory approvals; identify, enter into and maintain collaboration agreements with third parties; manage competition; manage expenses; raise the substantial additional capital needed to achieve its business objectives; attract and retain qualified personnel; and successfully execute on its business strategies; risks described under the caption “Risk Factors” in Syros’ Annual Report on Form 10-K for the year ended December 31, 2022 and Quarterly Report on Form 10-Q for the quarter ended March 31, 2023, each which is on the Securities and Exchange Commission; and risks described in other filings that Syros makes with the Securities and Exchange Commission in the future. Syros Pharmaceuticals, Inc. Selected Condensed Consolidated Balance Sheet Data (in thousands) (unaudited) March 31, 2023 December 31, 2022 Cash, cash equivalents and marketable securities (current and noncurrent) $ 165,803 $ 202,304 Working capital1 150,093 180,614 Total assets 205,323 244,486 Total stockholders’ equity 106,753 127,736 (1) The Company defines working capital as current assets less current liabilities. See the Company’s condensed consolidated financial statements for further details regarding its current assets and current liabilities. Syros Pharmaceuticals, Inc. Condensed Consolidated Statement of Operations (in thousands, except share and per share data) (unaudited) Three Months Ended March 31, 2023 2022 Revenue $ 2,954 $ 5,467 Operating expenses: Research and development 28,761 25,171 General and administrative 7,405 6,949 Total operating expenses 36,166 32,120 Loss from operations (33,212 ) (26,653 ) Interest income 1,775 35 Interest expense (1,217 ) (976 ) Change in fair value of warrant liability 8,865 2,448 Net loss applicable to common stockholders $ (23,789 ) $ (25,146 ) Net loss per share applicable to common stockholders - basic and diluted $ (0.85 ) $ (3.99 ) Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted 27,842,218 6,306,142

-- Commenced randomized portion of SELECT-AML-1 trial, with initial data expected in 4Q 2023 -- -- Received FDA Fast Track designation for tamibarotene for the treatment of HR-MDS -- -- On-track to complete enrollment in SELECT-MDS-1 trial in 4Q 2023, with pivotal data expected in 3Q 2024 -- -- Management to host conference call at 8:30 a.m. ET today -- CAMBRIDGE, Mass.--(BUSINESS WIRE)--Syros Pharmaceuticals (NASDAQ:SYRS), a biopharmaceutical company committed to advancing new standards of care for the frontline treatment of hematologic malignancies, today reported financial results for the quarter and full-year ended December 31, 2022 and provided a corporate update. “In 2022, we advanced our efforts to develop new standards of care for the frontline treatment of hematologic malignancies, announcing promising data from our ongoing studies in AML and APL and progressing our pivotal trial in HR-MDS,” said Nancy Simonian, M.D., Chief Executive Officer of Syros. “We believe we are well-positioned to build on this progress in the year ahead. We are also encouraged by the continued momentum in our global enrollment for SELECT-MDS-1. As evidenced by the FDA’s recent decision to grant Fast Track Designation to tamibarotene for HR-MDS, there is a clear need for new therapies that can address the needs of people living with this progressive and devastating disease and we are working with urgency, together with physicians around the world, to recruit and enroll the SELECT-MDS-1 trial. In addition, we have initiated the randomized portion of the SELECT-AML-1 Phase 2 trial and are actively screening patients. We expect to report initial data from SELECT-AML-1 in the fourth quarter of this year and to provide an update on the development path and timing for further evaluation of SY-2101 in a registration-enabling study in APL in the second half of this year.” Dr. Simonian continued, “Following our strategic financing in 2022, we are operating from a position of financial strength, with sufficient capital to fund our efforts into the second quarter of 2025. Importantly, we expect that this capital will bring us beyond Phase 3 data from the SELECT-MDS-1 trial and initial data from the randomized portion of the SELECT-AML-1 trial, while also allowing us to begin investing in the commercial infrastructure that will be necessary to deliver our products to patients.” UPCOMING MILESTONES Tamibarotene: Higher-Risk Myelodysplastic Syndrome (HR-MDS) Complete patient enrollment in the SELECT-MDS-1 Phase 3 trial in newly diagnosed HR-MDS patients with RARA gene overexpression in the fourth quarter of 2023. Report pivotal complete response (CR) data from the SELECT-MDS-1 Phase 3 trial in the third quarter of 2024. Tamibarotene: Acute Myelodysplastic Syndrome (AML) Announce initial data from the randomized portion of the SELECT-AML-1 Phase 2 trial in newly diagnosed unfit AML patients with RARA overexpression in the fourth quarter of 2023. Report additional data from the SELECT-AML-1 Phase 2 trial in 2024. SY-2101: Acute Promyelocytic Leukemia (APL) Provide an update on the dose confirmation study of SY-2101, as well as the development path and timing for further evaluation of SY-2101 in a registration-enabling study in APL, in the second half of 2023. RECENT PIPELINE HIGHLIGHTS Initiated the randomized portion of the SELECT-AML-1 study and ­­patient screening. The study is designed to evaluate the safety and efficacy of tamibarotene in combination with venetoclax and azacitidine compared to venetoclax and azacitidine in approximately 80 patients with RARA overexpression, randomized 1:1. The primary endpoint is composite complete response (cCR) rate. In February 2023, the U.S. Food and Drug Administration (FDA) granted Fast Track Designation to tamibarotene for the treatment of HR-MDS. Fast Track is a process designed by the FDA to facilitate the development and expedite the review of drugs that have the potential to treat serious conditions and address recognized areas of unmet medical need. In December 2022, Syros announced the publication in Blood Advances of results from the completed biomarker-directed Phase 2 trial of tamibarotene in combination with azacitidine in newly diagnosed unfit AML patients. In patients with RARA gene overexpression, the combination of tamibarotene and azacitidine demonstrated a cCR rate of 61%, with a rapid onset and clinically meaningful durability. In patients with low blast count AML, the CR rate was 67%. In addition, correlative analyses of RARA expression levels identified an association of RARA overexpression with a monocytic gene expression signature that may be associated with resistance to venetoclax. Together, these data support Syros’ ongoing evaluation of tamibarotene for the treatment of AML and MDS patients with RARA overexpression. At the 64th American Society for Hematology (ASH) Annual Meeting in December 2022, Syros presented data from six response-evaluable patients in the safety lead-in portion of the ongoing SELECT-AML-1 Phase 2 trial. Treatment with the triplet combination of tamibarotene, venetoclax and azacitidine in patients with RARA overexpression demonstrated an 83% cCR rate and rapid onset of action, with no evidence of increased toxicity relative to historical data of the venetoclax and azacitidine doublet combination. In December 2022, Syros also extended the research term under the collaboration agreement with Global Blood Therapeutics (GBT), now a part of Pfizer, for an additional year. Fourth Quarter and Full Year 2022 Financial Results Revenues were negative $0.8 million for the fourth quarter of 2022, as compared to $7.8 million in the fourth quarter in 2021. This decrease reflects a cumulative catch-up adjustment of revenue recognized under Syros’ collaboration with GBT as a result of extending the term of the research collaboration by one year. Revenues were $14.9 million for the year ended December 31, 2022, consisting of $13.6 million and $1.3 million from Syros’ collaborations with GBT and Incyte, respectively and $23.5 million for the year ended December 31, 2021. Research and development expenses were $27.9 million for the fourth quarter of 2022 and $111.9 million for the year ended December 31, 2022, as compared to $26.8 million for the fourth quarter of 2021 and $99.9 million for the year ended December 31, 2021. The increase for the fourth quarter of 2022 compared to the same period in 2021 and the increase for the year ended December 31, 2022 compared to the year ended December 31, 2021 were primarily due to the increase in costs associated with the continued advancement of our clinical programs and employee-related expenses. General and administrative (G&A) expenses were $7.3 million for the fourth quarter of 2022 and $29.3 million for the year ended December 31, 2022, as compared to $6.4 million for the fourth quarter of 2021 and $23.0 million for the year ended December 31, 2021. Transaction-related expenses of $9.5 million for the year ended December 31, 2022 primarily consist of incurred costs allocated to the warrants issued in connection with the PIPE financing that were accounted for as liabilities, and severance paid to former Tyme employees following our acquisition of Tyme in September 2022. For the fourth quarter of 2022, Syros reported a net loss of $4.8 million, or $0.17 per share, compared to a net loss of $23.8 million, or $3.78 per share, for the same period in 2021. For the full year ended December 31, 2022, Syros reported a net loss of $94.7 million, or $7.49 per share, compared to a net loss of $86.6 million, or $13.84 per share, for the same period in 2021. Cash and Financial Guidance Cash, cash equivalents and marketable securities as of December 31, 2022 were $202.3 million, as compared with $143.4 million on December 31, 2021. Based on its current plans, Syros believes that its existing cash, cash equivalents and marketable securities will be sufficient to fund its anticipated operating expenses and capital expenditure requirements into the second quarter of 2025, beyond Phase 3 data from the SELECT-MDS-1 trial and initial data from the randomized portion of the SELECT-AML-1 trial. Conference Call and Webcast Syros will host a conference call today at 8:30 a.m. ET to discuss these fourth quarter and full year 2022 financial results and provide a corporate update. To access the live conference call, please dial (888) 575-5167 (domestic) or (416) 764-8687 (international) and refer to conference ID 74534085. A webcast of the call will also be available on the Investors & Media section of the Syros website at . An archived replay of the webcast will be available for approximately 30 days following the presentation. About Syros Pharmaceuticals Syros is committed to developing new standards of care for the frontline treatment of patients with hematologic malignancies. Driven by the motivation to help patients with blood disorders that have largely eluded other targeted approaches, Syros is advancing a robust late-stage clinical pipeline, including tamibarotene, a first-in-class oral selective RARα agonist in patients with higher-risk myelodysplastic syndrome and acute myeloid leukemia with RARA gene overexpression, and SY-2101, a novel oral form of arsenic trioxide in patients with acute promyelocytic leukemia. Syros is also seeking partnerships for SY-5609, a highly selective and potent CDK7 inhibitor in clinical development for the treatment of select solid tumors, and multiple preclinical programs in oncology and monogenic diseases. For more information, visit and follow us on Twitter (@SyrosPharma) and LinkedIn. Cautionary Note Regarding Forward-Looking Statements This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995, including without limitation statements regarding Syros’ clinical development plans, including with respect to the progression of its clinical trials and the timing and impact of opening clinical sites, enrolling study participants and reporting clinical data, the ability to deliver benefit to patients, the potential benefits of receiving Fast Track designation, and the sufficiency of Syros’ capital resources to fund its operating expenses and capital expenditure requirements into the second quarter of 2025. The words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “hope,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “target,” “should,” “would,” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various important factors, including Syros’ ability to: advance the development of its programs, including tamibarotene and SY-2101, under the timelines it projects in current and future clinical trials; demonstrate in any current and future clinical trials the requisite safety, efficacy and combinability of its drug candidates; sustain the response rates and durability of response seen to date with its drug candidates; successfully develop a companion diagnostic test to identify patients with the RARA biomarker; obtain and maintain patent protection for its drug candidates and the freedom to operate under third party intellectual property; obtain and maintain necessary regulatory approvals; identify, enter into and maintain collaboration agreements with third parties; manage competition; manage expenses; raise the substantial additional capital needed to achieve its business objectives; attract and retain qualified personnel; and successfully execute on its business strategies; risks described under the caption “Risk Factors” in Syros’ Annual Report on Form 10-K for the year ended December 31, 2022, which is on the Securities and Exchange Commission; and risks described in other filings that Syros makes with the Securities and Exchange Commission in the future. Syros Pharmaceuticals, Inc. Selected Condensed Consolidated Balance Sheet Data (in thousands) (unaudited) December 31, 2022 December 31, 2021 Cash, cash equivalents and marketable securities (current and noncurrent) $ 202,304 $ 143,407 Working capital 180,614 105,077 Total assets 244,486 182,935 Total stockholders’ equity 127,736 85,218 Syros Pharmaceuticals, Inc. Condensed Consolidated Statement of Operations (in thousands, except share and per share data) (unaudited) Three Months Ended December 31, Year Ended December 31, 2022 2021 2022 2021 Revenue $ (754 ) $ 7,802 $ 14,880 $ 23,488 Operating expenses: Research and development 27,914 26,796 111,944 99,872 General and administrative 7,329 6,429 29,199 23,036 Transaction related expenses 0 0 9,510 0 Total operating expenses 35,243 33,225 150,753 122,908 Loss from operations (35,997 ) (25,423 ) (135,873 ) (99,420 ) Interest income 1,594 31 2,132 87 Interest expense (1,126 ) (986 ) (4,134 ) (3,907 ) Change in fair value of warrant liability 30,756 (2,565 ) 43,221 16,682 Net loss applicable to common stockholders $ (4,773 ) $ (23,813 ) $ (94,654 ) $ (86,558 ) Net loss per share applicable to common stockholders - basic and diluted $ (0.17 ) $ (3.80 ) $ (7.49 ) $ (13.80 ) Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted 27,753,257 6,259,088 12,631,968 6,553,497

COPENHAGEN, Denmark--( BUSINESS WIRE )--COLOTECT™ 3.0 is a non-invasive colorectal cancer screening test developed by BGI, and will be launched in early 2023. BGI plans to release pre-clinical case-control data for COLOTECT™ 3.0 at the 2023 ASCO Gastrointestinal Cancers Symposium. The sensitivity for detecting CRC is 96.08%. The sensitivity for detecting advanced precancerous lesions (APL) is 52.5%, which is better than FIT products. COLOTECT™ 3.0 is a non-invasive colorectal cancer (CRC) self-sampling test that can detect the methylation status of exfoliated cell genes and the Fecal Occult Blood in the stool. It can help screen for colorectal cancer and advanced precancerous lesions (APL) even in the absence of active bleeding lesions. Colorectal cancer is the third most common cancer and the second deadly cancer worldwide. There were more than 1.9 million new cases of colorectal cancer in 2020. Older age, a history of bowel disease, a family history of related diseases, having type 2 diabetes, overweight or obesity, certain types of diet, smoking, and drinking are all risk factors that can lead to colorectal cancer. In recent years, the incidence rate of colorectal cancer among people younger than 50 has been increasing significantly. As the tumor grows, patients may experience one or multiple symptoms, including blood in the stool, abdominal pain, and bloating. However, colorectal cancer usually does not produce symptoms in the early stages, which makes some patients undiagnosed until they are at the third or fourth stage and miss the best time for treatment. If colorectal cancer is diagnosed at early stages, the 5-year relative survival rate can be as high as 90%. Conversely, if it is diagnosed at stage IV, the 5-year survival rate will be only about 10%. To learn about the new method of colorectal cancer screening in under 90 seconds, please click on the following link: https://colotectglobal.com/about-colotect#video-gallery-1 Non-invasive, painless, convenient, and designed with privacy in mind, COLOTECT™ 3.0 can help catch colorectal cancer early and save lives.