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Last update 08 May 2025

Vascular Ulcer

Last update 08 May 2025

Basic Info

Synonyms-

Introduction-

Drugs associated with Vascular Ulcer

Recombinant human acidic fibroblast growth factor for external use

Target

FGFRs

Mechanism

FGFRs stimulants [+1]

Active Org.

Shanghai Tenry Pharmaceutical

Originator Org.

Jinan University

Active Indication

Burns [+4]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

China

First Approval Date31 Dec 2006

100 Clinical Results associated with Vascular Ulcer

100 Translational Medicine associated with Vascular Ulcer

0 Patents (Medical) associated with Vascular Ulcer

259

Literatures (Medical) associated with Vascular Ulcer

01 Apr 2025·Journal of Shoulder and Elbow Surgery

Novel Surgical Safety Zones on Bony-En-Face View of Humeral Greater Tuberosity: A Fresh Cadaveric Dissection Study

Article

Author: Tanaka, Yasuhito ; Vaseenon, Tanawat ; Mahakkanukrauh, Pasuk ; Sinthubua, Apichat ; Inthasan, Chanatporn ; Zhang, Baolu ; Liu, Gang ; Mahakkanukrauh, Chollada

BACKGROUNDThe neurovascular alignment in the humeral greater tuberosity (HGT) region has not been thoroughly investigated. However, many studies have documented the vascular-nerve architecture of the proximal humerus. The purpose of this study was to identify novel safety zones on the bony-en-face view of the HGT for surgical procedures.METHODSEighteen complete adult fresh-frozen cadavers (36 paired shoulders) were dissected in this study (12 males and 6 females; mean age of 69.39 years). Five landmarks-A, B, C, D, and E-were established to define the boundary of the HGT. Point A was the intersection of the superior facet of HGT and the intertubercular groove of the long head of the biceps tendon (LHBT). Point B was the junction of the attachment point between the supraspinatus and the infraspinatus muscle. Point C was the intersection of the infraspinatus and the teres minor muscle, and point D was the lowest foot point of the teres minor muscle. Point E was on a vertical intersection line from point D to point A. Next, we segmented the individualized pentagon ABCDE into 15 zones. First, we drew line BF to ensure it was perpendicular to DE. Then, we designated points H, J, and M as the midpoints of the supraspinatus, infraspinatus, and teres minor, respectively, with H and J perpendicular to DE and M perpendicular to EA. Finally, we drew perpendicular lines from points J, C, and M to EA, which intersected at points K, G, and L, respectively.The neurovascular structures in each zone were identified to enable the calculation of percentages, allowing for the definition of safe and dangerous zones.RESULTSWe have identified the specific ranking of the safe zones for branches of the circumflex humeral artery (bCHA) as follows: 1a (19.44%, meaning blood vessels were observed in 7 out of 36 shoulders, accounting for 19.44% of the total), 3a (25%), 2a (47.22%), 7 (66.66%), 2b (75%), 1b (77.77%), 3b (80.55%), 4, 10 and 11(all, 88.88%), 6 and 8 (both 91.67%), 5, 9 and 12 (all, 100%). The specific zone ranking of vascular-branch numbers is as follows: 1a<3a<2a<7 <2b<1b<10<3b<4<6<11< 8< 9<12<5. The specific ranking of the dangerous zones for the anterior branches of the axillary nerve (ABAN) is: 8 (5.55%), 11 (8.33%), 10 (38.88%), and 9 (66.66%).CONCLUSIONWe demonstrate the neurovascular distribution in the 15 zones on the bony-en-face view of the HGT, clearly highlighting both safe and dangerous zones. We recommend following clinical suggestions based on our anatomical findings: (1) Selection of safe insert points from zones 1a, 3a, 2a, or 7 for screw fixation(Liu-Gang Type I & II). (2) Avoidance of neurovascular dangerous zones 8, 11, 10, and 9 for plate fixation. However, we should keep in mind that this technique cannot prevent vascular disruption in these areas.

01 Apr 2025·Journal of Cosmetic Dermatology

The Kesty Redness Scale: A Pilot Validation Study for a Novel Tool for Evaluating Facial Redness in Cosmetic and Clinical Dermatology

Article

Author: Kesty, Katarina R. ; Kesty, Chelsea E.

ABSTRACTBackgroundFacial redness is a common concern in dermatology, affecting patients with conditions such as rosacea, post‐inflammatory erythema, and other vascular irregularities. Despite its prevalence, existing tools for quantifying facial redness are limited in their clinical utility and ease of use.AimsTo develop a high‐performing redness scale.MethodsThis study introduces the Kesty Redness Scale (KRS), outlines its development and validation process, and discusses its potential clinical applications.ResultsThe investigators rated the scale as useful and easy to use, and the majority stated they would use it in clinical practice to document patient characteristics. The results of the evaluation utilizing Gwet's AC2, Kendall's W, Spearman's ρ, Weighted Cohen's kappa, and Bland–Altman analysis —showcasing strong ordinal agreement, robust rank concordance, and negligible bias—demonstrate that this new rating system is both reliable and valid for measuring skin hyperpigmentation on a 0–3 scale.ConclusionsThe KRS is a reliable, easy‐to‐use tool that enhances the assessment of facial redness in dermatology. Its validation through expert evaluation and statistical analysis underscores its potential to improve clinical practice and research.

01 Mar 2025·Journal of Investigative Dermatology

Endothelial Dysfunction in Keloid Formation and Therapeutic Insights

Review

Author: Tey, Hong Liang ; Li, Zhijin ; Yu, Nanze ; Tan, Yingrou ; Wen, Junxian ; Wang, Xiaojun

Keloids are benign fibroproliferative tumors that cause significant physical and mental morbidity owing to their disfiguring appearance, chronic symptoms, and resistance to treatment. Although fibroblast hyperproliferation and excessive extracellular matrix deposition have been extensively studied, less attention has been paid to the role of vascular dysregulation and endothelial dysfunction (ED) in keloid pathogenesis. Emerging evidence highlights abnormal angiogenesis, vascular irregularities, and endothelial injury as critical drivers of fibrosis in keloids. This review explores the direct and indirect mechanisms of ED in keloid progression, including endothelial-to-mesenchymal transition, inflammation, immune cell crosstalk, and hypoxia. In addition, various treatment strategies targeting angiogenesis and ED, such as drugs, radiotherapy, hyperbaric oxygen therapy, compression, and laser treatments, are comprehensively reviewed. This review explores keloids through the lens of vasculature and endothelium, emphasizing the critical roles of vascular dysregulation and ED. It aims to provide insights into the mechanisms of keloid formation and serve as a reference for developing future therapeutic strategies.

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Vascular Ulcer

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