Obtained agreement from FDA to initiate a Phase 1 trial evaluating multiple doses of Rhenium (186Re) Obisbemeda for the treatment of patients with leptomeningeal metastases (LM) Presented positive ReSPECT-GBM Trial Data at the 2024 Congress of Neurological Surgeons Annual Conference Established Radiotherapeutic Manufacturing Partnership with SpectronRx to meet late-stage clinical and commercial forecasts for Rhenium (186Re) Obisbemeda AUSTIN, Texas, Nov. 14, 2024 (GLOBE NEWSWIRE) -- Plus Therapeutics, Inc. (Nasdaq: PSTV) (the “Company”), a clinical-stage pharmaceutical company developing targeted radiotherapeutics with advanced platform technologies for central nervous system (CNS) cancers, today announced financial results for the third quarter ended September 30, 2024, and provided an overview of recent and upcoming business highlights. Q3 2024 RECENT HIGHLIGHTS AND MILESTONES Completed enrollment in the Phase 1 ReSPECT-GBM trialObtained agreement from FDA to begin enrollment in the ReSPECT-LM multi-administration trial for patients with LM (IND 153715). The trial is expected to begin enrollment in early 2025 at seven U.S. trial sitesPresented positive ReSPECT-GBM Phase 1/2 Trial update data at the 2024 Congress of Neurological Surgeons Annual Conference, showing Rhenium (186Re) Obisbemeda continues to demonstrate promising feasibility, safety, response, and efficacy signals across 42 treated patients. Additional details can be found hereExpanded the ReSPECT-GBM Phase 1/2 Trial to new sites and referral regions: North Shore University in New York and Ohio State University in the Upper MidwestEntered into a Research and Collaboration Agreement with Brainlab, a leading, innovative software-driven med-tech company to implement optimized case planning software for convection-enhanced delivery or CED of Rhenium (186Re) Obisbemeda for brain cancersReceived a $0.9 million grant payment as part of the $3 million award by the Department of Defense (DoD) Peer Reviewed Cancer Research Program Advancing Cancer Care through Clinical Trials Award to support the clinical development of Rhenium (186Re) Obisbemeda for pediatric brain cancerEstablished a GMP manufacturing partnership with SpectronRx to meet late-stage clinical and commercial forecasts for Rhenium (186Re) Obisbemeda. Additional details can be found hereObtained CLIA registration for our Houston-based facility supporting the CNSide Cerebrospinal Fluid Tumor Cell Enumeration Assay Platform, with CLIA compliance certification anticipated in early 2025 “Securing agreement from the FDA to initiate a Phase 1 multiple dose administration trial is a key next step in our integrated development plan for Rhenium (186Re) Obisbemeda for patients with LM,” said Marc H. Hedrick, M.D., Plus Therapeutics’ President and Chief Executive Officer. “We are on track to complete both Phase 1 LM trials and move to later stage trials in 2025.” UPCOMING EXPECTED EVENTS AND MILESTONES Presentations planned for the following upcoming medical conferences: Society for Neuro-Oncology (SNO) Annual Conference (November 21-24, 2024) Rhenium (186Re) Obisbemeda (rhenium nanoliposome,186RNL) for the treatment of leptomeningeal metastases (LM): Summary of the Phase 1 dose escalation study and Phase 2 administered dose selectionCSF Tumor Cell (CSF-TC) Detection, Quantification and Biomarker assessment helps in clinical management of breast cancer and Non-Small Cell Lung cancer patients having Leptomeningeal DiseaseThe Oncogenic Flip in Patients with Leptomeningeal Metastatic Disease (LMD): Longitudinal Detection in Cerebrospinal Fluid Tumor Cells (CSF-TCs) Reveals Implications for Differential Treatment of the LMD Tumor San Antonio Breast Cancer Symposium (December 10-13, 2024) Rhenium (186Re) Obisbemeda (rhenium nanoliposome,186RNL) for the treatment of leptomeningeal metastases (LM): Update on Phase 1 dose escalation Complete ReSPECT-LM Phase 1 single dose administration trial and determine the maximum tolerated and recommended Phase 2 doses by year-endInitiate ReSPECT-LM Phase 1 multiple dose administration trial in 2025Complete ReSPECT-GBM Phase 2 enrollment by 2025Obtain IND approval for a Phase 1/2 trial of Rhenium (186Re) Obisbemeda for pediatric ependymoma and high-grade gliomaLaunch the CNSide Cerebrospinal Fluid Tumor Cell Enumeration Assay Platform as a laboratory-developed test (LDT) in 2025 THIRD QUARTER 2024 FINANCIAL RESULTS The Company’s cash and investments balance was $4.8 million at September 30, 2024 compared to $8.6 million at December 31, 2023. In addition, the Company received a $0.9 million grant payment from the DoD in October 2024, and is on track to receive the next CPRIT grant advance of $3.9 million within 90 days following this releaseThe Company recognized $4.4 million in grant revenue year to date through September 30, 2024, compared to $3.6 million for the same period in 2023, which in both periods represents the Cancer Prevention & Research Institute of Texas’ (CPRIT) share of the costs incurred for our Rhenium (186Re) Obisbemeda development for the treatment of patients with LMTotal operating loss year to date through September 30, 2024, was $10.8 million compared to $9.5 million for the same period in 2023. The increase is primarily due to increased spend related to the ReSPECT-LM trialNet loss year to date through September 30, 2024, was $9.1 million, or $(1.46) per basic share, compared to a net loss of $9.5 million, or $(3.54) per basic share, for the same period the prior year THIRD QUARTER 2024 RESULTS CONFERENCE CALL The Company will hold a conference call and live audio webcast at 5:00 pm Eastern Time today to discuss its financial results and provide a general business update. The live audio webcast will be available at ir.plustherapeutics.com/events. Participants may also pre-register any time before the call here. Once registration is completed, participants will be provided a dial-in number with a personalized conference code to access the call. Please dial in 15 minutes prior to the start time. Following the live call, a replay will be available on the Company’s website under the ‘For Investors’ section. The webcast will be available on the Company’s website for 90 days following the live call. About Plus TherapeuticsPlus Therapeutics, Inc. is a clinical-stage pharmaceutical company developing targeted radiotherapeutics for difficult-to-treat cancers of the central nervous system with the potential to enhance clinical outcomes for patients. Combining image-guided local beta radiation and targeted drug delivery approaches, the Company is advancing a pipeline of product candidates with lead programs in recurrent glioblastoma (GBM) and leptomeningeal metastases (LM). The Company has built a supply chain through strategic partnerships that enable the development, manufacturing and future potential commercialization of its products. Plus Therapeutics is led by an experienced and dedicated leadership team and has operations in key cancer clinical development hubs, including Austin and San Antonio, Texas. For more information, visit https://plustherapeutics.com/. Cautionary Statement Regarding Forward-Looking StatementsThis press release contains statements that may be deemed “forward-looking statements” within the meaning of U.S. securities laws, including statements regarding clinical trials, expected operations and upcoming developments. All statements in this press release other than statements of historical fact are forward-looking statements. These forward-looking statements may be identified by future verbs, as well as terms such as “expect” “potential,” “anticipating,” “planning” and similar expressions or the negatives thereof. Such statements are based upon certain assumptions and assessments made by management in light of their experience and their perception of historical trends, current conditions, expected future developments and other factors they believe to be appropriate. These statements include, without limitation, statements under the heading Upcoming Events and Expected Milestones, and statements regarding the following: CLIA compliance certification of the Company’s Houston-based clinical laboratory; the potential promise of rhenium (186Re) obisbemeda; expectations as to the Company’s future performance, including the next steps in developing the Company’s product candidates; the Company’s clinical trials, including statements regarding the timing and characteristics of the ReSPECT-GBM, ReSPECT-LM and ReSPECT-PBC clinical trials; the continued evaluation of rhenium (186Re) obisbemeda including through evaluations in additional patient cohorts;; development and utility of CNSide leptomeningeal metastases diagnostic test. The forward-looking statements included in this press release could differ materially from those expressed or implied by these forward-looking statements because of risks, uncertainties, and other factors that include, but are not limited to, the following: the early stage of the Company’s product candidates and therapies; the results of the Company’s research and development activities, including uncertainties relating to the clinical trials of its product candidates and therapies; the Company’s liquidity and capital resources and its ability to raise additional cash; the outcome of the Company’s partnering/licensing efforts, risks associated with laws or regulatory requirements applicable to it, including the ability of the Company to come into compliance with The Nasdaq Capital Market listing requirements; market conditions, product performance, litigation or potential litigation, and competition within the cancer diagnostics and therapeutics field; ability to develop and protect proprietary intellectual property or obtain licenses to intellectual property developed by others on commercially reasonable and competitive terms; challenges associated with radiotherapeutic manufacturing, production and distribution capabilities necessary to support the Company’s clinical trials and any commercial level product demand; and material security breach or cybersecurity attack affecting the Company’s operations or property. This list of risks, uncertainties, and other factors is not complete. Plus Therapeutics discusses some of these matters more fully, as well as certain risk factors that could affect Plus Therapeutics’ business, financial condition, results of operations, and prospects, in its reports filed with the SEC, including Plus Therapeutics’ annual report on Form 10-K for the fiscal year ended December 31, 2023, quarterly reports on Form 10-Q, and current reports on Form 8-K. These filings are available for review through the SEC’s website at www.sec.gov. Any or all forward-looking statements Plus Therapeutics makes may turn out to be wrong and can be affected by inaccurate assumptions Plus Therapeutics might make or by known or unknown risks, uncertainties, and other factors, including those identified in this press release. Accordingly, you should not place undue reliance on the forward-looking statements made in this press release, which speak only as of its date. The Company assumes no responsibility to update or revise any forward-looking statements to reflect events, trends or circumstances after the date they are made unless the Company has an obligation under U.S. federal securities laws to do so. Investor ContactCharles Y. Huang, MBADirector of Capital Markets and Investor RelationsOffice: (202)-209-5751 | Direct (301)-728-7222chuang@plustherapeutics.com PLUS THERAPEUTICS, INC.CONDENSED CONSOLIDATED BALANCE SHEETS(UNAUDITED)(in thousands, except share and par value data) September 30,2024 December 31,2023 Assets
Current assets:
Cash and cash equivalents $1,223 $8,554 Investments 3,565 — Other current assets — 1,280 Total current assets 4,788 9,834
Property and equipment, net 591 906 Operating lease right-of-use assets 106 202 Goodwill 372 372 Intangible assets, net 513 42 Other assets 32 32 Total assets $6,978 $11,388 Liabilities and Stockholders’ Equity
Current liabilities:
Accounts payable and accrued expenses $7,912 $6,631 Operating lease liability 68 120 Deferred grant liability 840 — Line of credit 3,292 — Term loan obligation, current — 3,976 Total current liabilities 12,112 10,727
Noncurrent operating lease liability 40 85 Deferred grant liability — 1,924 Total liabilities 12,152 12,736
Stockholders’ deficit:
Preferred stock, $0.001 par value; 5,000,000 shares authorized; 1,952 shares issued and outstanding at September 30, 2024 and December 31, 2023, respectively — — Common stock, $0.001 par value; 100,000,000 shares authorized; 6,154,758 and 5,896,333 issued and outstanding at September 30, 2024, and 4,522,656 issued and 4,444,097 outstanding as of December 31, 2023, respectively 6 5 Treasury stock (at cost, 258,425 and 78,559 shares as of September 30, 2024 and December 31, 2023, respectively) (500) (126)Additional paid-in capital 484,896 479,274 Accumulated deficit (489,576) (480,501)Total stockholders’ deficit (5,174) (1,348)Total liabilities and stockholders’ deficit $6,978 $11,388 PLUS THERAPEUTICS, INC.CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS(UNAUDITED)(in thousands, except share and per share data) For the Three Months Ended September 30, For the Nine Months Ended September 30, 2024 2023 2024 2023 Grant revenue $1,456 $1,240 $4,412 $3,600
Operating expenses:
Research and development 2,858 2,493 8,394 6,896 General and administrative 2,397 1,998 6,813 6,167 Total operating expenses 5,255 4,491 15,207 13,063 Loss from operations (3,799) (3,251) (10,795) (9,463)
Other income (expense):
Financing expense — — (3,545) — Change in fair value of warrants 960 — 5,654 — Warrant issuance costs (54) — (486) — Interest income 80 119 219 290 Interest expense (61) (87) (122) (333)Total other income (expense) 925 32 1,720 (43)Net loss $(2,874) $(3,219) $(9,075) $(9,506)
Per share information:
Net loss per share of common stock - basic $(0.37) $(1.00) $(1.46) $(3.54)Weighted average number of shares of common stock outstanding - basic 7,855,763 3,225,351 6,232,123 2,688,232 Net loss per share of common stock - diluted $(0.37) $(1.00) $(1.67) $(3.54)Weighted average number of shares of common stock outstanding - diluted 7,855,763 3,225,351 8,452,338 2,688,232 PLUS THERAPEUTICS, INC.CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS(UNAUDITED)(In thousands) For the Nine Months Ended September 30, 2024 2023 Cash flows used in operating activities:
Net loss $(9,075) $(9,506)Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization 524 477 Amortization of deferred financing costs and debt discount 20 160 Share-based compensation expense 422 428 Accretion of discount on short-term investments (70) — Non-cash financing expense 3,545 — Change in fair value of warrants (5,654) — Loss on disposal of property and equipment — 2 Amortization of operating lease right-of-use assets 96 86 Stock issued for research and development — 75 Increases (decreases) in cash caused by changes in operating assets and liabilities:
Grant receivable — (91)Other current assets 704 3,190 Accounts payable and accrued expenses 1,326 (4,061)Change in operating lease liabilities (97) (87)Deferred grant liability (1,084) (1,643)Net cash used in operating activities (9,343) (10,970)
Cash flows used in investing activities:
Purchases of property and equipment (135) (118)Redemption of short-term investments 3,650 — Purchase of short-term investments (7,145) — Purchase of intangible assets (545) — Net cash used in investing activities (4,175) (118)
Cash flows provided by financing activities:
Principal payments of term loan obligation (3,996) (1,206)Proceeds from credit facility 3,292 — Purchase of treasury stock (374) — Proceeds from sale of common stock, net of offering costs of $0.2 million — 5,180 Proceeds from sale of common stock, warrants and pre-funded warrants, net 7,265 — Net cash provided by financing activities 6,187 3,974 Net decrease in cash and cash equivalents (7,331) (7,114)Cash and cash equivalents at beginning of period 8,554 18,120 Cash and cash equivalents at end of period $1,223 $11,006
