Synonyms Epithelioid Hemangioendothelioma, Epithelioid Hemangioendotheliomas, Epithelioid haemangioendothelioma + [19] |
Introduction A tumor of medium-to-large veins, composed of plump-to-spindled endothelial cells that bulge into vascular spaces in a tombstone-like fashion. These tumors are thought to have "borderline" aggression, where one-third develop local recurrences, but only rarely metastasize. It is unclear whether the epithelioid hemangioendothelioma is truly neoplastic or an exuberant tissue reaction, nor is it clear if this is equivalent to Kimura's disease (see ANGIOLYMPHOID HYPERPLASIA WITH EOSINOPHILIA). (Segen, Dictionary of Modern Medicine, 1992) |
Target |
Mechanism IFNAR agonists [+2] |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. CN |
First Approval Date28 Jun 2018 |
Target |
Mechanism MEK1 inhibitors [+1] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date29 May 2013 |
Target |
Mechanism Tubulin inhibitors |
Active Org. |
Originator Org. |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date15 Nov 2010 |
Start Date27 Jun 2024 |
Sponsor / Collaborator |
Start Date26 Mar 2024 |
Sponsor / Collaborator |
Start Date01 Dec 2023 |
Sponsor / Collaborator |