Synonyms ALVEOLITIS FIBROSING, ALVEOLITIS, CHRONIC DIFFUSE FIBROSING, ALVEOLITIS, CHRONIC DIFFUSE SCLEROSING + [94] |
Introduction A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change. |
Target |
Mechanism CSF-1R antagonists |
Active Org. |
Originator Org. |
Active Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date14 Aug 2024 |
Target |
Mechanism IL-13 inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. EU [+3] |
First Approval Date16 Nov 2023 |
Target |
Mechanism P2X3 receptor antagonists |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. JP |
First Approval Date20 Jan 2022 |
Start Date30 Sep 2024 |
Sponsor / Collaborator |
Start Date01 Sep 2024 |
Sponsor / Collaborator Endeavor BioMedicines, IncStartup |
Start Date27 Jul 2024 |
Sponsor / Collaborator |