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Last update 08 May 2025

Gram-positive bacteremia

Last update 08 May 2025

Basic Info

Synonyms

GRAM POSITIVE BACTEREMIA, Gram-positive bacteraemia, Gram-positive bacteremia

+ [2]

Introduction-

Clinical Trials associated with Gram-positive bacteremia

CTIS2023-506734-73-00

/ RecruitingPhase 4IIT

Pharmacokinetics study of Cefazolin in haemodialysis (CEFAZODIAL) - DR220268

Start Date20 Nov 2023

Sponsor / Collaborator

Centre Hospitalier Regional Universitaire De Tours

NCT05605275

/ CompletedNot ApplicableIIT

CRP and PCT as Predictors of Bloodstream Infections in Surgical Patients With Isolation of G+ and G- Bacteria in 3 Year Period

The aim of this retrospective study is to determine the predictive role of serum level of procalcitonin (PCT) and c-reactive protein (CRP) in determining the causative agent of sepsis in surgical intensive care unit (ICU) patients. The main question it aims to answer is: what serum level of PCT and CRP is predictive of gram+ and gram- sepsis in patients with positive blood cultures in the surgical ICU. The study will be retrospective and will include all patients with positive blood cultures who were hospitalized in the surgical ICU of University Hospital Osijek in the period from January 2019 to May 2022.

Start Date05 Jan 2022

Sponsor / Collaborator-

NCT04847921

/ TerminatedPhase 2/3IIT

Preliminary Evaluation of Dalbavancin's Efficacy in People Who Use Drugs With Severe Gram-positive Infections

The Investigators aim to study the outcomes of serious infections due to vancomycin susceptible infections in gram-positive organisms susceptible to vancomycin in people who use drugs (PWUD). The Investigators hypothesize, that a simplified 2-dose dalbavancin regimen, will improve compliance with antimicrobial therapy and that it may facilitate engagement in the treatment of the underlying substance use disorder, and particularly injection drug use - often the true etiology behind these severe infections.

Start Date30 Apr 2021

Sponsor / Collaborator

University of Colorado Denver

100 Clinical Results associated with Gram-positive bacteremia

100 Translational Medicine associated with Gram-positive bacteremia

0 Patents (Medical) associated with Gram-positive bacteremia

659

Literatures (Medical) associated with Gram-positive bacteremia

24 Mar 2025·Cureus

Cryptococcus neoformans in Chronic Lymphocytic Leukemia (CLL) Treated With Ibrutinib: A Combo Gone Wrong!

Article

Author: MacQueen, Douglas ; Centellas Montano, Felipe ; Plocharczyk, Elizabeth ; Gupta, SushilKumar ; Yadav, Yogesh

A 71-year-old female, with hypertension, depression, and asthma, was diagnosed with chronic lymphocytic leukemia (CLL) (elevated beta-2 microglobulin and deletion of 13 q chromosome) and treated with ibrutinib. She had general weakness, dyspnea, fatigue, shortness of breath, upper abdominal fullness, and discomfort from splenomegaly. In the ED, her oxygen saturation (SpO₂) was 83% on room air, afebrile, and stable. Nasal oxygen at 3 L improved her hypoxemia and symptoms. An exam showed bilateral crackles, systolic murmur 2/6, non-tender abdomen with splenomegaly, and no lower extremities edema. A CT scan showed patchy ground glass opacities, interlobular septal thickening, and bilateral pleural effusion. Diuretics were given, but the patient's condition worsened, requiring ICU and bi-level positive airway pressure (BiPAP). Staphylococcus hominis was found in blood cultures, and vancomycin was started. Respiratory distress necessitated mechanical ventilation and intubation. Imaging suggested acute respiratory distress syndrome (ARDS), atypical pneumonia, or heart failure with preserved ejection fraction. Transthoracic echocardiogram showed normal ejection fraction with severely increased pulmonary artery pressure, and transesophageal echocardiogram showed no vegetation. Blood cultures monitored the Gram-positive bacteremia, with BioFire isolating Candida zeylanoides initially. Subsequent cultures over a week period were positive for C. zeylanoides and then Cryptococcus neoformans. Chest CT revealed a large mass of lymph nodes in the mediastinal area, which was thought to be causing pulmonary hypertension by compressing the pulmonary artery. After a multidisciplinary discussion, ibrutinib was withheld, and drug-induced pneumonitis was suspected. Fungemia was found in the immunocompromised patient, so the infectious disease team prescribed voriconazole for 13 days and then changed to amphotericin and fluconazole due to a lack of improvement. Eye examination showed no signs of endophthalmitis. Lumbar puncture showed no central nervous system (CNS) fungal infection. The patient's respiratory status worsened, so a bronchoscopy with bronchoalveolar lavage (BAL) of the right middle lobe and chest tube placement for pleural effusion was done. Microbiological examination of BAL and pleural effusion revealed C. neoformans and Klebsiella, confirming disseminated C. neoformans. Despite a tough 32-day hospital stay, the patient was discharged in stable condition. Physical therapy and nutrition optimization were used to enhance her health. This case report highlights the rare but serious complication of cryptococcal disease in patients using ibrutinib for blood cancers. Early comprehensive diagnosis and multi-disciplinary involvement saved our patient's life.

01 Feb 2025·Drugs

Treatment of Complicated Gram-Positive Bacteremia and Infective Endocarditis

Review

Author: Hagel, Stefan ; Schellong, Paul ; Joean, Oana ; Weis, Sebastian ; Pletz, Mathias W

The Gram-positive cocci Staphylococcus aureus, Streptococcus spp., and Enterococcus spp. are the most frequent causative organisms of bloodstream infections and infective endocarditis. "Complicated bacteremia" is a term used in S. aureus bloodstream infections and originally implied the presence of metastatic infectious foci (i.e. complications of S. aureus bacteremia). These complications demand longer antimicrobial treatment durations and, frequently, interventional source control. Several risk factors for the incidence of bacteremia complications have been identified and are often used for the definition of complicated bacteremia. Here, we discuss management and diagnostic approaches and treatment options for patients with complicated bacteremia, with particular focus on infective endocarditis. We also summarize the available evidence regarding imaging modalities and the choice of antimicrobial mono- or combination therapy according to resistance patterns for these pathogens as well as treatment durations and optimized application routes. Finally, we synopsize current and future areas of research in complicated bacteremia and infective endocarditis.

01 Feb 2025·Annales de Cardiologie et d'Angéiologie

Pseudo-anévrisme du trigone mitro-aortique : cas clinique et revue de littérature

Review

Author: Attilio, Leone ; Emmanuel, Joly ; Sophie, Hennebicq ; David, Haberman ; Didier, De Cannière ; Philippe, Unger

CASE REPORTWe report the case of a 63-year-old patient who underwent aortic valve replacement with a biological valve for a bicuspid aortic stenosis, and LIMA-IVA single-bypass surgery. Two weeks later, he presented with Enterococcus faecillis bacteremia, attributed to left pyelonephritis and successfully treated with Amoxicillin. Two months after his surgery, he had a new bacteremia due to Enterococcus faecalis and we discovered a pseudo-aneurysm of the mitro-aortic trigone. Our patient is treated medically at first, before benefiting from the "Hemi-Commando" procedure.DISCUSSIONThe mitro-aortic trigone is a fibrous area, located between the left half of the noncoronary cusp and the left coronary cusp of the aortic valve and the anterior leaflet of the mitral valve [1]. This area, important in the maintenance of mitral and aortic functions, [ii] is poorly vascularized and therefore very susceptible to infections and trauma [2]. Erosion of the aortic ring leads to the formation of a subvalvular abcess, secondarily detergated en then leads to the destruction of the trigone.CONCLUSIONSPseudoaneurysm is a rare complication of aortic valve surgery and endocarditis. Given the risk of rupture, early surgery is recommended.

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Gram-positive bacteremia

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