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Last update 08 May 2025

Cytomegalic Inclusion Body Disease

Last update 08 May 2025

Basic Info

Synonyms

Cytomegalic inclusion body disease, 巨细胞包涵体病

Introduction-

Drugs associated with Cytomegalic Inclusion Body Disease

DP1038

Target-

Mechanism-

Active Org.-

Originator Org.

Dauntless Pharmaceuticals, Inc.

Active Indication-

Inactive Indication

Acromegaly [+2]

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Cytomegalic Inclusion Body Disease

ChiCTR2100048211

/ SuspendedNot ApplicableIIT

Retrospective study of congenital microvilli inclusion body disease

Start Date01 Jul 2021

Sponsor / Collaborator-

100 Clinical Results associated with Cytomegalic Inclusion Body Disease

100 Translational Medicine associated with Cytomegalic Inclusion Body Disease

0 Patents (Medical) associated with Cytomegalic Inclusion Body Disease

366

Literatures (Medical) associated with Cytomegalic Inclusion Body Disease

01 Jul 2025·Microbial Pathogenesis

Emerging Co-infection of avian adenovirus and astrovirus in Lebanese poultry

Article

Author: El Hage, Jeanne ; Ghorayeb, Elie ; Abi-Rizk, Alain

In the spring of 2023, several "broiler breeder" and "broiler" farms in North Lebanon were affected by a disease that impaired general performance and caused severe daily mortalities. Despite antibiotic treatments, there was no significant improvement. Serological analysis indicated that the flocks were protected against Infectious Bursal Disease (IBD), Infectious Bronchitis Virus (IBV), Avian Influenza (AI), and Newcastle Disease Virus (NDV). However, necropsy revealed severe liver lesions and swollen kidneys. This study investigated the possible presence of avian adenovirus (FAdV), which causes inclusion body hepatitis, and avastrovirus (AstV), which causes hepatitis and runting stunting syndrome, in Lebanese breeders and broilers. For the first time, a co-infection between FAdV and AstV was described. Both viruses were detected by PCR and RT-PCR. DNA sequencing identified the FAdV as adenovirus E type 8b and adenovirus D type 2 and the AstV as avastrovirus type 2. This comprehensive study identified the primary cause of the atypical body inclusion hepatitis and runting stunting syndrome observed in North Lebanon.

01 Jun 2025·Microbial Pathogenesis

Delayed nuclear localization of CRISPR/Cas9-modified fiber of fowl adenovirus serotype 8b reduces pathogenicity in Specific pathogen-free chicken embryonic liver cells

Article

Author: Omar, Abdul Rahman ; Abdul Razak, Mariatulqabtiah ; Mat Isa, Nurulfiza ; Azli, Bahiyah ; Ahmed, Salisu ; Hair-Bejo, Mohd ; Ideris, Aini

Fowl adenovirus (FAdV) poses incessant outbreaks to poultry production worldwide, and Inclusion body hepatitis (IBH) is a predominant FAdV infectious disease. Currently, limited vaccines are available in Malaysia to fight against the local predominant FAdV strain 8b isolate (FAdV-8b), posing a desperate demand for efficient vaccine development. The fiber protein of FAdV is one of the major constituents of the adenoviral capsid involved in the virulence of pathogens. Hence, the aim was to modify the fiber gene of FAdV-8b UPMT27 to develop a live attenuated FAdV vaccine via the gene-editing CRISPR/Cas9 technology. Primary specific pathogen-free (SPF) chicken embryonic liver cells (CELs) infected with the modified isolated (cfUPMT27) were reported with significantly reduced cytopathic effects, delayed viral localization into the nucleus, and low apoptotic rates. cfUPMT27 isolate also exhibited constant amino acid substitution of Y179D in subsequent passages. Meanwhile, the liver of cfUPMT27 inoculated-SPF chicken embryonic eggs (CEE) was observed with mild hydropericardium and reported with a delayed mortality at 6-days post-infection (dpi). This holistic, integrative study incorporating genetic, pathology, and immunology analysis proposed cfUPMT27 isolate as a candidate vaccine for FAdV infections, providing efficient future protection in chickens.

01 Apr 2025·Veterinary Microbiology

A novel recombinant chimeric Fiber-8a/8b-AD subunit vaccine provides complete protection against both FAdV-8a and FAdV-8b

Article

Author: Yuan, Wanzhe ; Wang, Xiangqin

In recent years, outbreaks of fowl adenovirus (FAdV) in domestic chicken populations in China, particularly fowl adenovirus serotype 8 (FAdV-8), have attracted significant attention due to its role as a major causative agent of inclusion body hepatitis (IBH). Although FAdV-8 exhibits lower virulence compared to FAdV-4, its ability to co-infect with other pathogens presents new challenges for vaccine development. In this study, full-length and chimeric expression technologies were applied to develop four novel subunit vaccines using Fiber proteins from FAdV-8a and FAdV-8b strains: Fiber-8a-AB, Fiber-8b-CD, Fiber-8a/8b-AD, and Fiber-8b/8a-CB. Immunogenicity experiments indicated that the Fiber-8a/8b-AD subunit vaccine induced production of antibodies at 14 days of age earlier than the other three subunit vaccine. Moreover, the neutralizing antibody level of the Fiber-8a/8b-AD subunit vaccine group was higher than the three subunit vaccine groups. Immuno-challenge tests confirmed that this vaccine effectively protected chickens from weight loss, liver damage, and viral shedding post FAdV-8a and FAdV-8b infection. These findings valuable crucial insights for the development of new vaccines and suggest that the Fiber-8a/8b-AD subunit vaccine has the potential to serve as an effective alternative to inactivated whole-virus vaccines, with substantial commercial potential.

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