Request Demo

Last update 08 May 2025

Linitis Plastica

Last update 08 May 2025

Basic Info

Synonyms

Leather-bottle stomach, Linitis Plastica, Linitis plastica

+ [18]

Introduction

A condition where the stomach wall becomes thickened, rubbery and loses its ability to distend. The stomach assumes a "leather bottle" shape. It is most often seen in adenocarcinoma of the stomach. The term is often used synonymously with diffuse adenocarcinoma of the stomach.

Drugs associated with Linitis Plastica

Dovitinib

Target

FGFR3 x FLT3 x PDGFRβ x VEGFR x c-Kit

Mechanism

FGFR3 antagonists [+4]

Active Org.

Oncoheroes Biosciences Inc

[+1]

Originator Org.

Novartis Pharma AG

Active Indication

Ovarian Cancer [+1]

Inactive Indication

Acetyl-Coa Carboxylase Deficiency [+43]

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Linitis Plastica

NCT06451211

/ RecruitingPhase 2IIT

Phase II Study of Neoadjuvant Immunotherapy Plus Chemotherapy in Borrmann Type 4 and Large Type 3 Gastric Cancer (Neo-ICEBOAT Study)

The aim of this study is to test the efficacy and safety of immunotherapy plus chemotherapy on people with a relatively rare type of gastric cancer. Participants will take the anti-PD-1 inhibitor (Tislelizumab) and platinum-based chemotherapy (oxaliplatin + capecitabine or oxaliplatin + S-1) in a 3-week cycle, followed by a radical operation after 6 cycles.

Start Date17 May 2023

Sponsor / Collaborator

Sun Yat-Sen University

NCT01576380

/ CompletedPhase 2

A Single-arm, Multi-center, Phase II Study to Evaluate Efficacy and Safety of Dovitinib (TKI258) in Adult Patients With Advanced Scirrhous Gastric Carcinoma That Have Progressed After One or Two Prior Systemic Treatments

This is a prospective, open-label, single-arm, non-randomized, multi-center, phase II proof of concept (PoC) study with a two-stage design and Bayesian interim monitoring to evaluate efficacy and safety of single agent TKI258 in adult patients with scirrhous gastric carcinoma (SGC) that have progressed after one or two prior systemic treatments.

Start Date01 Jun 2012

Sponsor / Collaborator

Novartis Pharmaceuticals Corp.

100 Clinical Results associated with Linitis Plastica

100 Translational Medicine associated with Linitis Plastica

0 Patents (Medical) associated with Linitis Plastica

587

Literatures (Medical) associated with Linitis Plastica

03 Apr 2025·Scandinavian Journal of Gastroenterology

Identification of novel biomarkers for gastric adenocarcinoma through two-sample Mendelian randomization analysis of the human plasma proteome

Article

Author: Guo, Zhanfei ; Zhang, Zhiwei ; Liu, Yanbao ; Huo, Zhongchao ; Tian, Jingjing ; Cai, Qingrui ; Li, Shiying

BACKGROUNDPapillary gastric adenocarcinoma (PGC), a histological subtype of gastric cancer (GC), is characterized by malignant potential and poor prognosis. Therefore, identifying novel biomarkers is urgently needed to enhance PGC diagnosis and treatment outcomes.METHODSThis study utilized two-sample Mendelian randomization (MR) to explore potential causal relationships between human blood plasma proteins and GC. Heterogeneity testing, pleiotropy assessment, and directionality analyses were performed to evaluate identified plasma proteins. Additionally, pathway enrichment analysis was conducted to elucidate the molecular mechanisms underlying the causal associations between plasma proteins and GC development.RESULTSMR analysis of 4,907 plasma proteins related to GC risk identified 90 proteins with potential causal relationships. The findings revealed that DNAJB9, CHCHD10, and suppressor of cytokine signaling 3 exhibited protective effects against GC, while Syntaxin-8, alcohol dehydrogenase 7, and UDP-glucose 4-epimerase were associated with increased GC risk at the genetic level.CONCLUSIONIn the present study, the six plasma proteins identified through comprehensive MR analysis may serve as potential biomarkers for GC, offering new insights for future molecular diagnosis and therapeutic strategies.

07 Mar 2025·Cureus

Atypical Presentation of Metastatic Breast Cancer: Gastric Outlet Obstruction and Linitis Plastica

Article

Author: Smith, Riley L ; Ross, Cassidy ; Patel, Arpankumar

Linitis plastica (LP) is a rare stomach cancer that has a high mortality rate due to late presentation and limited available therapies. LP has a varied clinical presentation and can present at all stages. LP can be a primary or secondary neoplastic process. Rarely, it occurs secondary to breast cancer (BC). In this case report, we present an 88-year-old female patient who has a history of right breast ductal adenocarcinoma. She underwent chemoradiation eight years ago and was in remission when she presented with nausea, vomiting, weakness, and jaundice. During an endoscopic ultrasound and endoscopic retrograde cholangiopancreatography, multiple biopsies were taken of epigastric lymph nodes and the gastric wall. The biopsy showed metastatic BC, and the lymph nodes were positive for metastatic adenocarcinoma, resulting in a diagnosis of LP secondary to BC. Although difficult to diagnose, this case report details the need for a lower threshold of endoscopic evaluation in a patient with a history of BC. It also emphasizes the need for further research into potential treatment options.

04 Mar 2025·Minimally Invasive Therapy & Allied Technologies

Endoscopic ultrasound-guided bite-on-bite biopsy and endoscopic ultrasound-guided fine-needle aspiration in the diagnosis of gastric tumors with negative malignant endoscopy biopsies: a retrospective cohort study

Article

Author: Wang, Yongjun ; Chu, Yi ; Lv, Liang ; Tan, Yuyong ; Liu, Deliang ; Min, Liang ; Chen, Jiefei ; Zhu, Hongyi ; Jin, Yan ; Zhou, Yuqian ; Liang, Chengbai

BACKGROUNDSpecific types of gastric tumors, including gastric linitis plastica and lymphoma, may cause extensive deep-layer infiltration, impeding an accurate diagnosis with endoscopic biopsy. This study aims to evaluate the efficacy of endoscopic ultrasound (EUS)-guided bite-on-bite biopsy and EUS-guided fine-needle aspiration (EUS-FNA) in diagnosing gastric malignancies with negative endoscopic biopsies.METHODSWe retrospectively analyzed suspicious malignant gastric lesion cases in our hospital from October 2017 to August 2023. Clinical manifestations, radiographical examinations, endoscopic examinations, histopathological results, and therapeutic strategies were recorded and analyzed.RESULTSForty malignant gastric tumor cases with negative endoscopic biopsies were incorporated into our study. EUS-guided bite-on-bite biopsy was performed in 16 cases exclusively, whereas 17 patients received EUS-FNA exclusively, and seven patients underwent both simultaneously. Among the 23 patients who received the EUS-guided bite-on-bite biopsy, 22 (95.7%) were diagnosed with malignancies. Among the 24 patients who received EUS-FNA, a total of 19 cases with malignancies (79.2%) were confirmed by EUS-FNA (p = 0.11): 13 gastric adenocarcinomas, five metastatic malignancies, and one malignant stromal tumor. No adverse events were observed in any of the cases.CONCLUSIONSEUS-guided bite-on-bite biopsy and EUS-FNA possess their advantages and disadvantages. EUS-guided bite-on-bite biopsy could serve as a reliable diagnostic method for shallow lesions with negative malignant endoscopic biopsies.

Analysis

Perform a panoramic analysis of this field.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Linitis Plastica

Basic Info

Related

Analysis