Acrospiroma

Last update 08 May 2025

Basic Info

Synonyms

Acrospiroma, Acrospiroma, Eccrine, Acrospiromas

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Introduction

A rare cutaneous tumor of apocrine or eccrine SWEAT GLAND origin. It is most commonly found on the extremities and is usually benign. It appears as a solitary nodule or cyst and may be solid or produce a watery discharge. It is related to POROMA except in acrospiroma it does not involve the epidermis. There is no indication that heredity or external agents cause these tumors.

100 Clinical Results associated with Acrospiroma

100 Translational Medicine associated with Acrospiroma

0 Patents (Medical) associated with Acrospiroma

1,063

Literatures (Medical) associated with Acrospiroma

01 Jul 2025·Modern Pathology

RNA In Situ Hybridization Detection of CRTC1/3::MAML2 Fusions and LINC00473 in Mucoepidermoid Carcinomas and Hidradenomas of Breast, Salivary Glands, and Skin

Article

Author: Bishop, Justin A ; Das, Ishani ; Chen, Yunn-Yi ; Bremer, Ryan ; Bean, Gregory R ; Rutland, Cooper D ; Bridge, Julia A ; Wang, Aihui ; Kingsley, Leandra ; Zdravkovic, Sabrina ; Laser, Jordan S ; Krings, Gregor

Genomic rearrangements involving MAML2 have been reported in mucoepidermoid carcinoma (MEC) arising in various anatomical sites, as well as the benign counterpart of hidradenoma (HA). Depending on the location, MAML2-rearranged neoplasms may share morphologic overlap with additional diagnostic entities, including other salivary gland malignancies and cutaneous mimics. In some cases, detection of a CRTC1::MAML2 or less common CRTC3::MAML2 rearrangement by fluorescence in situ hybridization (ISH) or next-generation sequencing may be necessary to help confirm the diagnosis. However, such testing can be time consuming, relatively expensive, and unavailable in many pathology laboratories. We describe the development and validation of an ISH custom BaseScope assay targeting the recurrent breakpoints of CRTC1::MAML2 and CRTC3::MAML2 rearrangements. Moreover, we investigated the diagnostic utility of LINC00473 RNAscope as a surrogate marker for MAML2 fusion status. LINC00473 is a long noncoding RNA reportedly downstream of the CRTC1::MAML2 oncoprotein. We evaluated 227 patient cases, including 30 salivary gland and 2 breast MEC, 14 cutaneous and 8 breast HA, and 173 cases representing >20 potential histologic entities in the differential diagnosis for the presence of each fusion transcript by BaseScope, and a subset of cases (n = 205) for the detection of LINC00473 by RNAscope. RNA ISH was directly visualized by chromogenic signal, and the MAML2 fusion partner could be positively identified in the majority of cases. Overall, RNA ISH demonstrates high concordance with orthogonal testing, with CRTC1/3::MAML2 BaseScope showing 93% sensitivity and 100% specificity and LINC00473 RNAscope showing 92% sensitivity and 99% specificity. RNA ISH for CRTC1/3::MAML2 rearrangements and LINC00473 represent reasonable timely and cost-effective alternatives to fluorescence ISH and next-generation sequencing. Such markers may provide the means for accurate diagnosis to ensure appropriate therapy of MEC and HA-neoplasms that can arise in multiple anatomical sites and be encountered by a wide range of pathologists.

01 Jun 2025·Radiology Case Reports

A rare case of pineal astrocytoma with hemorrhagic changes: Diagnostic and surgical challenges

Article

Author: Kumari, Anjali ; Bhangale, Paritosh ; Shinde, Dhananjay ; Shrivastava, Priyal ; Kashikar, Shivali ; Patil, Ravishankar ; Parihar, Pratapsingh Hanuman

Pineal astrocytoma is an uncommon central nervous system tumor, presenting diagnostic and therapeutic challenges due to its deep-seated location and nonspecific clinical features. This case report describes a 37-year-old female who presented with altered sensorium, persistent headache, and projectile vomiting for 20 days. Initial examination revealed stable vitals and a reduced Glasgow Coma Scale score, necessitating immediate intubation. Magnetic resonance imaging (MRI) of the brain revealed a solid-cystic lesion in the pineal region with intraventricular extension, mass effect on the midbrain, and hemorrhagic changes. Magnetic resonance spectroscopy (MRS) findings, including elevated choline and lipid peaks with reduced N-acetyl aspartate, suggested a neoplastic etiology. The patient underwent a suboccipital craniotomy via a supracerebellar infratentorial approach for partial tumor excision. Histopathological analysis confirmed the lesion as a grade IV astrocytoma. Postoperative recovery was stable, and further management with adjuvant radiotherapy and chemotherapy was planned due to the high-grade nature of the tumor. This case highlights the importance of integrating clinical findings, advanced imaging techniques, and histopathological evaluation to accurately diagnose and manage rare pineal region tumors. Despite surgical intervention, the prognosis for high-grade astrocytomas remains poor, underscoring the necessity for continued research into targeted therapies and novel treatment approaches.

01 May 2025·Radiology: Imaging Cancer

Eccrine Spiradenoma with Diffusion Restriction at MRI

Article

Author: Mady, Leila J. ; Nadgir, Rohini ; Lakhani, Dhairya A. ; Akakpo, Kenneth ; Marchalik, Rachel

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Acrospiroma

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