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Last update 08 May 2025

Negative Rheumatoid Factor Polyarthritis

Last update 08 May 2025

Basic Info

Synonyms

Negative rheumatoid factor polyarthritis, RF-ve CP, Rheumatoid factor negative erosive chronic polyarthritis

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Introduction-

Clinical Trials associated with Negative Rheumatoid Factor Polyarthritis

ACTRN12621001657819

/ RecruitingPhase 1/2

A Randomised, Double-Blind, Placebo-Controlled, Parallel Dose Comparison Study Evaluating Safety and Efficacy of SVT-6A4710 in Adults with active Rheumatoid Arthritis.

Start Date21 Nov 2022

Sponsor / Collaborator-

NCT02437461

/ Unknown statusPhase 4IIT

Dosing of Intra-articular Triamcinolone Hexacetonide for Knee Synovitis in Chronic Polyarthritis

This prospective randomised controlled single blind trial comparing the relapse rate in 6 months for 20 mg versus 40 mg intraarticular triamcinolone hexacetonide (Lederspan®) for knee synovitis in patients with rheumatoid arthritis (RA) and psoriatic artritis (PsoA) is performed to find the optimal dose to use.

Start Date01 Apr 2015

Sponsor / Collaborator

University of Uppsala

100 Clinical Results associated with Negative Rheumatoid Factor Polyarthritis

100 Translational Medicine associated with Negative Rheumatoid Factor Polyarthritis

0 Patents (Medical) associated with Negative Rheumatoid Factor Polyarthritis

282

Literatures (Medical) associated with Negative Rheumatoid Factor Polyarthritis

04 Mar 2025·Schizophrenia Bulletin

Schizotypal Traits, Psychopathology, and Reflective Functioning Impairments During Adolescence: A Bayesian Network Approach

Article

Author: Pérez-Albéniz, Alicia ; Debbané, Martin ; Al-Halabí, Susana ; Fonseca-Pedrero, Eduardo ; Lucas-Molina, Beatriz

AbstractBackgroundNew theoretical and measurement models related to Bayesian networks can usefully be implemented to enrich our understanding of psychosis risk. The present study aims to explore, using a directed acyclic graph (DAG), the putative causal relationship within schizotypal facets, as well as between schizotypal dimensions, psychopathology, and reflective functioning (RF) impairments, in a representative sample of non-clinical adolescents.Study DesignA sample of 1476 adolescents from the general population participated in a cross-sectional survey. The Oviedo Schizotypy Assessment Questionnaire-Revised, the Strengths and Difficulties Questionnaire, and the Reflective Functioning Questionnaire (RFQ) were used.Study ResultsSchizotypal traits were positively associated with psychopathology and hypomentalizing. Putative causal relationships are presented between Reality distortion, Social disorganization, and Anhedonia. In addition, estimated DAG suggests that schizotypal dimensions influence psychopathology and RF impairments.ConclusionsThe findings suggest different pathways connecting schizotypal traits, mental health problems, and RF impairments during adolescence. The use of probabilistic DAG may allow us to make more robust conclusions about the direction of causation and to unravel potentially complex causal chains in the study of psychosis risk.

16 Jan 2025·Modern Rheumatology Case Reports

Symptomatic pachydermodactyly: A case report

Article

Author: Horita, Ayako ; Nogi, Shinichi ; Ohmatsu, Hanako ; Honda, Shogo ; Ito, Ayaka ; Yano, Yusuke ; Tabira, Yoshihiko ; Saito, Ikuo ; Tsuno, Hirotaka ; Matsui, Toshihiro

ABSTRACTPachydermodactyly, an uncommon variant of digital fibromatosis, predominantly affects young men and results in fibrous swelling on the sides of the proximal interphalangeal joints. It is generally considered benign and asymptomatic, requiring only regular follow-up. Nevertheless, the absence of established diagnostic criteria has led to misdiagnoses, prompting the administration of unnecessary medications. In this report, we present a 14-year-old Japanese male with symptomatic pachydermodactyly (PDD), necessitating careful differentiation from juvenile idiopathic arthritis (JIA) due to the presence of morning stiffness. Despite exhibiting typical PDD features, the patient’s age and symptoms suggested rheumatoid factor-negative polyarticular JIA. However, the lack of inflammatory findings precluded a JIA diagnosis. Following confirmation of the absence of uveitis and progression of bone destruction, the morning stiffness spontaneously resolved without active treatment. However, the patient underwent surgery for aesthetic reasons to alleviate the persistent swelling. Our case highlights the nuances of symptomatic PDD, with a literature review revealing similarities between symptomatic and asymptomatic cases. This challenges the suitability of asymptomatic status as a definitive diagnostic criterion. Our findings contribute to the ongoing efforts in establishing diagnostic criteria for PDD, aiming to reduce misdiagnoses and unnecessary medications in patients.

01 Dec 2024·Clinical Rheumatology

Relationship between SLCO1B1 polymorphisms and methotrexate intolerance in Mexican children with juvenile idiopathic arthritis

Article

Author: Villarreal-Treviño, Ana V ; Silva-Ramirez, Beatriz ; Garcia-Rodriguez, Fernando ; Garcia-Silva, Jimena ; Rubio-Perez, Nadina E ; Mata-Tijerina, Viviana

INTRODUCTIONThe most frequent adverse events (AEs) of methotrexate (MTX) are gastrointestinal symptoms and hepatotoxicity, which can affect its adherence, leading to reduced effectiveness. The SLCO1B1 gene codes for a liver protein (OATP1B1) responsible for drug transportation. Genetic variations within the SLCO1B1 gene locus impact drug transport, leading to altered pharmacokinetic profiles, delayed MTX clearance, and increased risk of toxicity. This study aimed to determine the association between single nucleotide polymorphisms (SNPs) in the SLCO1B1 gene (rs4149056, rs2306283) with the development of AEs in patients with juvenile idiopathic arthritis (JIA) treated with MTX.METHODWe performed an observational retrospective study to analyze the relationship between SNPs in the SLCO1B1 gene and the development of AEs in pediatric patients treated with MTX for JIA.RESULTSThirty patients with JIA were included, 22 females (73.3%), with a median age of 11 years (IQR 8.3-15). The most frequent JIA subtype was rheumatoid factor-positive polyarthritis (36.7%). Twenty patients (66.7%) reported AEs. The *1B haplotype was the most frequent in this group (53.3%) and conferred a higher risk of developing AEs (OR = 3.89, 95% CI = 1.23 -12.29, p = 0.03).CONCLUSIONSPatients with the allele *1B may benefit from lower doses of MTX. SLCO1B1 genotyping is a promising technique to identify patients at higher risk of AEs during treatment with MTX, thus requiring dose optimization.

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Negative Rheumatoid Factor Polyarthritis

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