Delving into the Latest Updates on Sertaconazole Nitrate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Dermofix, Dermoseptic, Fisderm

+ [11]

Target

fungal CYP51A1

Mechanism

fungal CYP51A1 inhibitors(Fungal CYP51A1 inhibitors)

Therapeutic Areas

Infectious DiseasesSkin and Musculoskeletal Diseases

Active Indication

Tinea PedisMycoses

Inactive Indication

CANDIDIASIS MUCOSALCandidiasis, VulvovaginalDermatitis, Atopic

Originator Organization

Bausch Health Americas, Inc.

Active Organization

Lacerta Therapeutics, Inc.Startup

Hainan Haishen Tongzhou Pharmaceutical Co Ltd.

Inactive Organization

Spirig Pharma AG

Drug Highest PhaseApproved

First Approval Date

DE (03 Nov 1995),

Mycoses

Regulation-

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Structure

Molecular FormulaC20H15Cl3N2OS

InChIKeyJLGKQTAYUIMGRK-UHFFFAOYSA-N

CAS Registry99592-32-2

View All Structures (2)

Candida onychomycosis is a common fungal infection affecting the nails, primarily caused by Candida (C.) species. Regarding the increasing trend of Candida onychomycosis and the antifungal resistant phenomenon in recent years, this study aims to evaluate the epidemiological characteristics of Candida onychomycosis, the distribution of emerging species, and the antifungal susceptibility profiles of isolates. Onychomycosis caused by yeast species was confirmed through direct examination and culture of nail scraping among all individuals suspected to have onychomycosis and referred to a medical mycology laboratory between June 2019 and March 2022. Species of yeast isolates were identified using the multiplex PCR and PCR-RFLP methods. The antifungal susceptibility of isolates to common antifungal agents and imidazole drugs was evaluated according to the M-27-A3 CLSI protocol. Among 101 yeast strains isolated from onychomycosis, Candida parapsilosis complex (50.49%) was the most common species, followed by C. albicans (20.79%) and C. tropicalis (10.89%). Rare species of yeasts such as C. guilliermondii and Saccharomyces cerevisiae were also identified by molecular methods. Results obtained from antifungal susceptibility testing showed significant differences in MIC values of isoconazole, fenticonazole, and sertaconazole among different species. Overall, a fluconazole-resistant rate of 3% was found among Candida species. Moreover, there was a statistically significant difference in MICs of fenticonazole and clotrimazole between the two most prevalent causative species, C. parapsilosis complex and C. albicans. Correct identification of the causative agents of onychomycosis and performing susceptibility testing could be helpful in choosing the most appropriate antifungal therapy.

01 Sep 2023·Medical Journal Armed Forces India

Comparative evaluation of the efficacy of itraconazole with terbinafine cream versus itraconazole with sertaconazole cream in dermatophytosis: A within person pilot study

Article

Author: Kothari, Rohit ; Vashisht, Deepak ; Baveja, Sukriti ; Venugopal, Ruby ; Kumar Joshi, Rajneesh

BackgroundCurrent trend of rising drug-resistant dermatophyte infection is alarming and fretted by dermatologists. Dilemma prevails regarding use of the same or different class of antifungal agents topically and systemically. The aim was to study the efficacy of oral itraconazole 200 mg with 1% terbinafine cream versus oral itraconazole 200 mg with 2% sertaconazole cream in dermatophytosis.MethodsThis within-person open-label pilot study enrolled 50 patients with dermatophytosis. Two lesions of comparable size within each patient were randomly allotted to group A and B and treated with 2% sertaconazole and 1% terbinafine cream, respectively. Both groups received itraconazole 200 mg once daily for 4 weeks. The remaining lesions received 1% terbinafine cream. Response and adverse effects were assessed at 2 and 4 weeks. Reduction in erythema, scaling, pruritus and clinical, and mycological cure constituted efficacy outcomes.ResultsThe mean duration of lesions was 2.82 ± 1.35 months. Complete clinical cure was observed in 50% and 48%, whereas mycological cure was attained in 56% and 52% patients in groups A and B, respectively, after 4 weeks, which was statistically insignificant. Reduction in erythema, scaling, and pruritus after 4 weeks when compared between the two groups, was also statistically insignificant.ConclusionSame class of oral and topical antifungal agents has comparable efficacy with different classes of oral and topical antifungal agents in dermatophyte infection.

09 Aug 2023·Mini-Reviews in Medicinal Chemistry

Therapeutic Potential of Thiophene Compounds: A Mini-Review

Review

Author: Verma, Prabhakar Kumar ; Sapra, Ashu ; Sharma, Shweta ; Kashid, Sarfraj ; Chawla, Shivani

Abstract:A rising number of researchers are interested in thiophene-based analogs as they have wide possibilities of biological potential in the largely developing chemical world of the heterocyclic moiety. It also occupies a central position in synthetic organic chemistry and is of the highest theoretical and practical importance. It became an important moiety for researchers to discover combinatorial libraries and implement the efforts in search of the lead entity. Moreover, it helps medicinal chemists to improve sophisticated molecules with a broad range of pharmacological activities. Thiophene and its synthetic derivatives are a prominent heterocyclic compound class with intriguing uses in medical chemistry. It has been manifesting to be an effective drug in current respective diseases scenario. It has been discovered that thiophene had an extensive spectrum of pharmacological potential with numerous applications in academic interest, in the pharmaceutical industry, material science, and medicinal chemistry. Antimitotic, antimicrobial, anti-inflammatory, anticonvulsant, antipsychotic, antiarrhythmic, anti-anxiety, antifungal, antioxidant, estrogen receptor regulating, and anti-cancer are one of the pharmacological and physiological activities of thiophene moiety. However, there are some marketed formulations available such as Thiophenfurin, Teniposide, Cefoxitin, Ticaconazole, Sertaconazole, Suprofen, ketotifen, Brinzolamide, Dorzolamide, Tiotropium which contain thiophene nucleus. Thus, in brief, gathering recent data is necessary to comprehend the present scenario of thiophene moiety for scientific research purposes and highlights a broad view of the biological potential of compounds having a thiophene nucleus.

100 Deals associated with Sertaconazole Nitrate

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External Link

KEGG	Wiki	ATC	Drug Bank
D08510	Sertaconazole Nitrate	D01AC14 G01AF19	DB01153

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Tinea Pedis	CN	Hainan Haishen Tongzhou Pharmaceutical Co Ltd.	09 Sep 2003
Mycoses	DE	-	03 Nov 1995

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
CANDIDIASIS MUCOSAL	Preclinical	CN	-	09 Oct 2013
Candidiasis, Vulvovaginal	Preclinical	CN	-	28 Sep 2013
Dermatitis, Atopic	Preclinical	DE	Spirig Pharma AG	01 Feb 2013