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Last update 08 May 2025

Octotiamine

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Octotiamine (JAN/INN), TATD, Neuvita

+ [1]

Target-

Action-

Mechanism-

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication

Thiamine Deficiency

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC23H36N4O5S3

InChIKeyVJTXQHYNRDGLON-UHFFFAOYSA-N

CAS Registry137-86-0

100 Clinical Results associated with Octotiamine

100 Translational Medicine associated with Octotiamine

100 Patents (Medical) associated with Octotiamine

Literatures (Medical) associated with Octotiamine

01 Feb 2025·Food Bioscience

Anti-Aspergillus niger mechanism of small molecular combinations of essential oils and their application in extending the shelf-life of bread

Author: Yang, Qingli ; Zhang, Qian ; Feng, Zhiruo ; Ju, Jian ; Li, Changjian ; Wang, Yihui ; Zhao, Fangyuan

Aspergillus niger is a primary microorganism responsible for spoilage in baked goods, making the inhibition of its growth and the extension of shelf-life highly significant.This study examined the antifungal mechanism of the citral-eugenol combination (CEC) against A. niger and its potential application in extending the shelf-life of bread.CEC-treated A. niger exhibited typical characteristics of early apoptosis, such as reactive oxygen species accumulation, increased intracellular Ca²⁺ concentration, and phosphatidylserine extravasation.Further anal. revealed that a decrease in mitochondrial membrane potential and the release of cytochrome c from mitochondria into the cytoplasm were accompanied by increased metacaspase activity, suggesting that CEC induces apoptosis in a metacaspase-dependent manner.Meanwhile, gel electrophoresis and qRT-PCR showed that DNA degradation and the relative expression levels of apoptosis factors (Actin, AiF, Fis, Tat-D, Casp) were increased.In terms of application, the addition of AY-CEC microcapsules could reduce the water vapor permeability of F-AY-CEC films by 28.14 %, while increasing the tensile strength, elongation at break, elastic modulus, and water contact angle by 183.23 %, 23.87 %, 212.33 %, and 33.82 %, resp.The shelf-life experiment showed that the shelf-life of bread could be extended from the 4th day to the 10th day by the film containing CEC microcapsules.

01 Mar 2023·Current Medicinal Chemistry

Microwave Induced Green Synthesis: Sustainable Technology for Efficient Development of Bioactive Pyrimidine Scaffolds

Review

Author: Banik, Bimal Krishna ; Tiwari, Varsha ; Kumar, Manish ; Sahoo, Biswa Mohan ; Singh, Sunil ; Tiwari, Abhishek ; Panda, Krishna Chandra ; Kumar, Bera Venkata Varaha Ravi

Abstract:Microwave radiation is used as a heating source during the synthesis of heterocyclic compounds. The heating mechanisms involved in microwave-induced synthesis include dipolar polarization and ionic conduction. This heating technology follows the green protocol as it involves the use of recyclable organic solvents during synthesis. The microwave heating approach offers a faster rate of reaction, easier work-up procedure, and higher product yield with purity and also reduces environmental pollution. So, microwave heating is applied as a sustainable technology for the efficient production of pyrimidine compounds as one of the heterocyclic moieties. Pyrimidine is a six-membered nitrogenous heterocyclic compound that plays a significant role due to several therapeutic applications. This moiety acts as an essential building block for generating drug candidates with diverse biological activities, including anti-cancer (capecitabine), anti-thyroid (propylthiouracil), antihistaminic (pemirolast), antimalarial (pyrimethamine), antidiabetic (alloxan), antihypertensive (minoxidil), anti-inflammatory (octotiamine), antifungal (cyprodinil), antibacterial (sulfamethazine), etc. This review is focused on the synthesis of pyrimidine analogs under microwave irradiation technique and the study of their therapeutic potentials.

01 Jan 2022·Life Sciences

Blocking I Ag7 class II major histocompatibility complex by drug-like small molecules alleviated Sjögren's syndrome in NOD mice

Article

Author: Li, Danmeng ; Ostrov, David A ; Gupta, Shivai ; Nguyen, Cuong Q

BACKGROUNDSjögren's syndrome (SjS) is an autoimmune disease with a strong genetic association. To date, no vaccine or therapeutic agent exists to cure SjS, and patients must rely on lifelong therapies to treat symptoms. Human leukocyte antigens (HLA) are primary susceptibility loci that form the genetic basis for many autoimmune diseases, including SjS. In this study, we sought to determine whether blocking MHC class II IAg⁷ antigen presentation in the NOD mouse would alleviate SjS by preventing the recognition of autoantigens by pathogenic T cells.METHODSMapping of the antigenic epitopes of Ro60 autoantigen to IAg⁷ of the NOD mice was performed using structural modeling and in-vitro stimulation. Tetraazatricyclo-dodecane (TATD) and 8-Azaguanine (8-Aza) were previously identified as potential binders to IA^g7 of the NOD mice using in silico drug screening. Mice were treated with 20mgs/kg via IP every day five days/week for 23 weeks. Disease profiling was conducted.FINDINGSSpecific peptides of Ro60 autoantigen were identified to bind to IAg⁷ and stimulated splenocytes of the NOD mice. Treating NOD mice with TATD or 8-Azaguanine alleviated SjS symptoms by improving salivary and lacrimal gland secretory function, decreasing the levels of autoantibodies, and reducing the severity of lymphocytic infiltration in the salivary and lacrimal glands.INTERPRETATIONThis study presents a novel therapeutic approach for SjS by identifying small molecules capable of inhibiting T cell response via antigen-specific presentation.FUNDINGCQN is supported financially in part by PHS grants AI130561, DE026450, and DE028544 from the National Institutes of Health.

100 Deals associated with Octotiamine

External Link

KEGG	Wiki	ATC	Drug Bank
D01184	Octotiamine	A11DA	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Thiamine Deficiency	-	-	-

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