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Last update 20 Mar 2025

Octotiamine

Last update 20 Mar 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Octotiamine (JAN/INN), TATD, Neuvita

+ [1]

Target-

Action-

Mechanism-

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication

Thiamine Deficiency

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC23H36N4O5S3

InChIKeyVJTXQHYNRDGLON-UHFFFAOYSA-N

CAS Registry137-86-0

100 Clinical Results associated with Octotiamine

100 Translational Medicine associated with Octotiamine

100 Patents (Medical) associated with Octotiamine

Literatures (Medical) associated with Octotiamine

01 Mar 2023·Current Medicinal Chemistry

Microwave Induced Green Synthesis: Sustainable Technology for Efficient Development of Bioactive Pyrimidine Scaffolds

Review

Author: Banik, Bimal Krishna ; Kumar, Manish ; Tiwari, Varsha ; Singh, Sunil ; Sahoo, Biswa Mohan ; Tiwari, Abhishek ; Panda, Krishna Chandra ; Kumar, Bera Venkata Varaha Ravi

Abstract:Microwave radiation is used as a heating source during the synthesis of heterocyclic compounds. The heating mechanisms involved in microwave-induced synthesis include dipolar polarization and ionic conduction. This heating technology follows the green protocol as it involves the use of recyclable organic solvents during synthesis. The microwave heating approach offers a faster rate of reaction, easier work-up procedure, and higher product yield with purity and also reduces environmental pollution. So, microwave heating is applied as a sustainable technology for the efficient production of pyrimidine compounds as one of the heterocyclic moieties. Pyrimidine is a six-membered nitrogenous heterocyclic compound that plays a significant role due to several therapeutic applications. This moiety acts as an essential building block for generating drug candidates with diverse biological activities, including anti-cancer (capecitabine), anti-thyroid (propylthiouracil), antihistaminic (pemirolast), antimalarial (pyrimethamine), antidiabetic (alloxan), antihypertensive (minoxidil), anti-inflammatory (octotiamine), antifungal (cyprodinil), antibacterial (sulfamethazine), etc. This review is focused on the synthesis of pyrimidine analogs under microwave irradiation technique and the study of their therapeutic potentials.

01 Jan 2022·Life Sciences

Blocking I Ag7 class II major histocompatibility complex by drug-like small molecules alleviated Sjögren's syndrome in NOD mice

Article

Author: Li, Danmeng ; Gupta, Shivai ; Ostrov, David A ; Nguyen, Cuong Q

BACKGROUNDSjögren's syndrome (SjS) is an autoimmune disease with a strong genetic association. To date, no vaccine or therapeutic agent exists to cure SjS, and patients must rely on lifelong therapies to treat symptoms. Human leukocyte antigens (HLA) are primary susceptibility loci that form the genetic basis for many autoimmune diseases, including SjS. In this study, we sought to determine whether blocking MHC class II IAg⁷ antigen presentation in the NOD mouse would alleviate SjS by preventing the recognition of autoantigens by pathogenic T cells.METHODSMapping of the antigenic epitopes of Ro60 autoantigen to IAg⁷ of the NOD mice was performed using structural modeling and in-vitro stimulation. Tetraazatricyclo-dodecane (TATD) and 8-Azaguanine (8-Aza) were previously identified as potential binders to IA^g7 of the NOD mice using in silico drug screening. Mice were treated with 20mgs/kg via IP every day five days/week for 23 weeks. Disease profiling was conducted.FINDINGSSpecific peptides of Ro60 autoantigen were identified to bind to IAg⁷ and stimulated splenocytes of the NOD mice. Treating NOD mice with TATD or 8-Azaguanine alleviated SjS symptoms by improving salivary and lacrimal gland secretory function, decreasing the levels of autoantibodies, and reducing the severity of lymphocytic infiltration in the salivary and lacrimal glands.INTERPRETATIONThis study presents a novel therapeutic approach for SjS by identifying small molecules capable of inhibiting T cell response via antigen-specific presentation.FUNDINGCQN is supported financially in part by PHS grants AI130561, DE026450, and DE028544 from the National Institutes of Health.

01 Dec 2018·Parasites & VectorsQ2 · MEDICINE

Expression and functional analysis of the TatD-like DNase of Plasmodium knowlesi

Q2 · MEDICINE

ArticleOA

Author: Jiang, Ning ; Yang, Na ; Sang, Xiaoyu ; Xiao, Bo ; Feng, Ying ; Zhou, Yapan ; Jiang, Lubin ; Chen, Qijun

BACKGROUNDIn recent years, human infection by the simian malaria parasite Plasmodium knowlesi has increased in Southeast Asia, leading to growing concerns regarding the cross-species spread of the parasite. Consequently, a deeper understanding of the biology of P. knowlesi is necessary in order to develop tools for control of the emerging disease. TatD-like DNase expressed at the surface of P. falciparum has recently been shown to counteract host innate immunity and is thus a potential malaria vaccine candidate.METHODSThe expression of the TatD DNase of P. knowlesi (PkTatD) was confirmed by both Western-blot and immunofluorescent assay. The DNA catalytic function of the PkTatD was confirmed by digestion of DNA with the recombinant PkTatD protein in the presence of various irons.RESULTSIn the present study, we investigated the expression of the homologous DNase in P. knowlesi. The expression of TatD-like DNase in P. knowslesi (PkTatD) was verified by Western blot and indirect immunofluorescence assays. Like that of the P. falciparum parasite, PkTatD was also found to be located on the surface of erythrocytes infected by the parasites. Biochemical analysis indicated that PkTatD can hydrolyze DNA and this activity is magnesium-dependent.CONCLUSIONSWe identified that PkTatD expressed on the surface of P. knowlesi-infected RBCs is a Mg²⁺-dependent DNase and exhibits a stronger hydrolytic capacity than TatD from P. falciparum. The data support our previous findings that TatD-like DNase is a unanimously expressed virulence factor of Plasmodium parasites.

100 Deals associated with Octotiamine

External Link

KEGG	Wiki	ATC	Drug Bank
D01184	Octotiamine	A11DA	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Thiamine Deficiency	-	-	-

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