Last update 18 Apr 2026

TJ-111

Overview

Basic Info

Drug Type
Dual payload Antibody drug conjugate (Dual payload ADC)
Synonyms
TJ 111, TJ111
Target
Top I x Trop-2 x Tubulin x nectin-4
Action
inhibitors
Mechanism
TOP1 inhibitors(DNA topoisomerase I inhibitors), Trop-2 inhibitors(Tumor-associated calcium signal transducer 2 inhibitors), Tubulin inhibitors
Therapeutic Areas
NeoplasmsUrogenital Diseases
Active Indication-
Inactive Indication
Urethral Neoplasms
Originator Organization
Phrontline Biopharma (Suzhou) Co., Ltd.Phrontline Biopharma (Suzhou) Co., Ltd.
Active Organization-
Inactive Organization
Phrontline Biopharma (Suzhou) Co., Ltd.Phrontline Biopharma (Suzhou) Co., Ltd.
License Organization-
Drug Highest PhaseDiscontinuedPreclinical
First Approval Date-
Regulation-

Structure/Sequence

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Related

100 Clinical Results associated with TJ-111
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100 Translational Medicine associated with TJ-111
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100 Patents (Medical) associated with TJ-111
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100 Deals associated with TJ-111
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Urethral NeoplasmsPreclinical
China
Phrontline Biopharma (Suzhou) Co., Ltd.Phrontline Biopharma (Suzhou) Co., Ltd.
01 Jun 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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