Delving into the Latest Updates on T-3 with Synapse

Overview

Basic Info

Drug Type

Proteolysis-targeting chimeras (PROTAC)

Synonyms

Target

TAU x α-synuclein

Mechanism

TAU inhibitors(Microtubule-associated protein tau inhibitors), α-synuclein inhibitors(Synuclein alpha inhibitors)

Therapeutic Areas

Nervous System Diseases

Active Indication

Neurodegenerative Diseases

Inactive Indication-

Originator Organization

Sun Yat-Sen University

Active Organization

Sun Yat-Sen University

Inactive Organization-

Drug Highest PhaseDiscovery

First Approval Date-

Regulation-

Structure

Molecular FormulaC35H35N5O9S

InChIKeyHJGFWWQBMXKVJY-UHFFFAOYSA-N

CAS Registry-

Gene Sequence

Sequence Code 14338201

This study is a phase II, parallel, prospective, randomized, double-blind, placebo controlled trial. The present study will aim to address the efficacy and safety of acute administration of triiodothyronine on ICU patients diagnosed with pulmonary infection due to COVID-19 and require mechanical respiratory support or ECMO.

Start Date29 May 2020

Sponsor / Collaborator

Uni-Pharma Kleon Tsetis Pharmaceutical Laboratory S.A

NL-OMON45854 / CompletedNot ApplicableIIT

rhTSH and T3 stimulation tests in offspring of long-lived siblings and their partners - THYRAGE

Start Date21 Nov 2016

Sponsor / Collaborator

Academisch Ziekenhuis Leiden

100 Clinical Results associated with T-3

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100 Translational Medicine associated with T-3

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100 Patents (Medical) associated with T-3

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4,104

Literatures (Medical) associated with T-3

01 Jan 2025·General and Comparative Endocrinology

Thyroid hormones activate TH/E2 receptor/regulator system and drive Na+/K+-ATPase in the ovarian wall of hypothyroid air-breathing fish (Anabas testudineus Bloch)

Article

Author: Viswanath, Meenu ; Peter, M C Subhash ; Peter, M.C.Subhash

In fish, as in other vertebrates, thyroid hormones (THs) act on many biological processes including growth and reproduction. Primary THs such as thyroxine (T₄) and triiodothyronine (T₃) are known for their direct action on osmoregulatory organs regulating ion osmotic homeostasis in many teleost fishes. However, it is unclear how these hormones interact with estradiol-17β (E₂), an ovarian hormone that regulates the development of oocytes. We thus examined the short-term in vivo action of varied THs such as T_4, T₃ and T₂, a potent TH metabolite diiodothyronine, on the expression pattern of receptors of THs and E₂ in the ovarian wall of the hypothyroid climbing perch to identify the interactive pattern of TH/E₂ receptor system and the molecular dynamics of Na⁺/K⁺ -ATPase (NKA) subunits in the ovarian wall that provides structural and functional support to ovary. We found differential pattern of transcript abundance of NKA subunits isoforms such as nkaα1a, nka<1b, nka<1c atp1b1, atp1b2 and fxyd3, fxyd5, fxyd6, TH receptor isoforms (tr<, trβ, tr2 receptor (er<, erβ, gper), aromatases (cyp19a1a, cyp19a1b) and steroidogenic enzymes (17β-hsd, sf-1, star) in ovarian wall in response to T₄, T₃ and T₂ administration in MMI-treated fish. The transcript abundance pattern provides evidence for a direct role of THs in the ovarian wall of hypothyroid fish. It confirms a targeted interaction of THs with ER/cyp19a1 and NKA systems. Pattern analysis further revealed that T₄ could produce maximum activation of the TR/Deo/Mct and ER/cyp19a1 systems among three iodinated tyrosines, bringing synergistic interaction between the TH and E₂ systems in the ovarian wall. This novel evidence of direct interaction between the TH/E₂ system and the NKA system in the ovarian wall further testifies to an ion osmotic role for THs in this ovarian structure.

01 Jan 2025·Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology

The influence of triiodothyronine on the immune response and extracellular matrix remodeling during zebrafish heart regeneration

Article

Author: Shaftoe, Jared B. ; Shaftoe, Jared B ; Baylis, Benjamin ; Long, Reece R.B. ; Bullingham, Oliver M.N. ; Gillis, Todd E. ; Dutcher, John R ; Gillis, Todd E ; Long, Reece R B ; Bullingham, Oliver M N ; Dutcher, John R.

Damage to the human heart is an irreparable process that results in a permanent impairment in cardiac function. There are, however, a number of vertebrate species including zebrafish (Danio rerio) that can regenerate their hearts following significant injury. In contrast to these regenerative species, mammals are known to have high levels of thyroid hormones, which has been proposed to play a role in this difference in regenerative capacity. However, the mechanisms through which thyroid hormones effect heart regeneration are not fully understood. Here, zebrafish were exposed to exogenous triiodothyronine (T₃) for two weeks and then their hearts were damaged through cryoinjury to investigate the effect of thyroid hormones on ECM remodeling and the components of the immune response during heart regeneration. Additionally, cardiac fibroblasts derived from trout, another species of fish known to display cardiac regenerative capacity, were exposed to T₃in vitro to analyze any direct effects of T₃ on collagen deposition. It was found that cryoinjury induction results in an increase in myocardial stiffness, but this response was muted in T₃ exposed zebrafish. The measurement of relevant marker gene transcripts suggests that T₃ exposure reduces the recruitment of macrophages to the damaged zebrafish heart immediately following injury but had no effect on the regulation of collagen deposition by cultured trout fibroblasts. These results suggest that T₃ effects both the immune response and ECM remodeling in zebrafish following cardiac injury.

01 Dec 2024·Veterinary and Animal Science

Effects of dietary supplementation with vitamin A, D3, E, and garlic on heat detection, pregnancy rate, and serum profile in anestrus dairy cows

Article

Author: Talukder, Rumon ; Nath, Sabuj Kanti ; Lovelu, Md Asaduzzaman ; Hossain, Md Shahadat ; Hossain, Md. Shahadat ; Ferdouse, Shaolin ; Lovelu, Md. Asaduzzaman ; Rahman, Nahid

Anestrus poses substantial challenges for dairy industries worldwide. This research aims to evaluate the effect of oral supplementation with garlic alone, vitamins A, D₃, E alone, and their combination on heat detection, pregnancy rate and serum profile in anestrus dairy cows. Using a completely randomized design, this study, conducted over 327 days, evaluated 72 anestrus-affected cows, which were divided into four groups. T₀ (Control) received only normal saline; T₁ with vitamin A,D₃,E; T₂ with Garlic and T₃ integrated with A, D₃, E + Garlic in drinking water. Results demonstrated that the treatment groups exhibited significantly higher estrus signs (p < 0.05) compared to the control. The pregnancy rate was also increased (P = 0.059), especially in the T₃ group which had the highest heat detection (55.55 %), conception (70 %), and pregnancy (38.88 %). In comparison, the heat detection rate for T₁ was 44.44 %, while the conception rate for T₂ was 66.66 %. Additionally, T₀ exhibited the least proportion across all parameters. Additionally, the elevated BUN (Blood Urea Nitrogen) and blood glucose levels observed in non-responsive (those not showing signs of heat) cows at 32.51 and 43.65 mg/dl respectively, compared to responsive cows (those showing signs of heat) with levels of 22.40 and 51.34 mg/dl. These findings suggest a potential association between these blood parameters and the cyclicity of dairy cows. These findings highlight that oral supplementation with vitamin AD₃E+Garlic significantly improves the heat detection rate and pregnancy rate than only administering vitamin AD₃E or Garlic with anestrus in dairy cattle.

100 Deals associated with T-3

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