Delving into the Latest Updates on Milk Exosome-mRNA Oral COVID-19 Vaccine (Exosome Technology) with Synapse

Overview

Basic Info

Drug Type

Exosomes, Prophylactic vaccine, mRNA vaccine

Synonyms

Exosome-Loaded SARS-CoV-2 RBD mRNA

Target

SARS-CoV-2 S protein

Action

inhibitors

Mechanism

SARS-CoV-2 S protein inhibitors(SARS-CoV-2 S protein inhibitors)

Therapeutic Areas

Infectious DiseasesRespiratory Diseases

Active Indication

COVID-19

Inactive Indication-

Originator Organization

Tingo Exosomes Technology Co., Ltd

Active Organization

Tingo Regenerative Medicine Technology Co., LtdTingo Exosomes Technology Co., Ltd

Inactive Organization-

License Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has presented numerous challenges to global health. Vaccines, including lipid-based nanoparticle mRNA, inactivated virus, and recombined protein, have been used to prevent SARS-CoV-2 infections in clinics and have been immensely helpful in controlling the pandemic. Here, we present and assess an oral mRNA vaccine based on bovine-milk-derived exosomes (milk-exos), which encodes the SARS-CoV-2 receptor-binding domain (RBD) as an immunogen. The results indicate that RBD mRNA delivered by milk-derived exosomes can produce secreted RBD peptides in 293 cells in vitro and stimulates neutralizing antibodies against RBD in mice. These results indicate that SARS-CoV-2 RBD mRNA vaccine loading with bovine-milk-derived exosomes is an easy, cheap, and novel way to introduce immunity against SARS-CoV-2 in vivo. Additionally, it also can work as a new oral delivery system for mRNA.

100 Deals associated with Milk Exosome-mRNA Oral COVID-19 Vaccine (Exosome Technology)

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
COVID-19	Preclinical	China	Tingo Regenerative Medicine Technology Co., Ltd	16 Mar 2023
COVID-19	Preclinical	China	Tingo Exosomes Technology Co., Ltd	16 Mar 2023