Delving into the Latest Updates on Adsorbed Tetanus Toxoid(Research Fdn for Microbial Diseases of Osaka University) with Synapse

Overview

Basic Info

Drug Type

Prophylactic vaccine, Toxoid vaccine

Synonyms-

Target

Tetanus toxin

Action

inhibitors

Mechanism

Tetanus toxin inhibitors

Therapeutic Areas

Infectious DiseasesOther Diseases

Active Indication

Tetanus

Inactive Indication-

Originator Organization

Research Fdn for Microbial Diseases of Osaka University

Active Organization

Research Fdn for Microbial Diseases of Osaka University

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Specific immunity to tetanus toxin is only artificially acquired and is provided by the presence in the blood and in the extravascular fluids of an IgG antibody passively administered or actively produced by the organism through vaccine injections. In the first case serum of human origin is now preferred to serum of animal origin due to the lack of major undesirable reactions and longer duration of protection (about 4 weeks versus 7-10 days). Tetanus toxoid is one of the most safe and potent known immunogens. For primary immunization adsorbed toxoid is given on two occasions at 2 months interval with a third reinforcing dose approximately one year after the second. The subsequent antitoxin response persists at protective level for at least 5 years and for a longer time (10 years about) after a booster. The ability to promptly react to a booster injection (immunological memory) is greatly long-lasting in persons who have previously received at least two doses.

31 Jan 1976·Schweizerische medizinische Wochenschrift

[Paralysis after tetanus prevention].

Article

Author: Waridel, D ; Gersbach, P

A rare case is presented of isolated paralysis of the left dentatus muscle in a 29-year-old woman following antitetanus vaccination by adsorbed toxoid injection in the left shoulder. In the light of a literature review the peculiarities of this case are pointed out and the risk factors which emerge from the patient's history are stressed. The discussion centres on the most favorable site for injection of toxoid, the controverted etiology of the affection and the desirability of some form of treatment.

100 Deals associated with Adsorbed Tetanus Toxoid(Research Fdn for Microbial Diseases of Osaka University)

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