Delving into the Latest Updates on Isopropiram Fumarate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target

μ opioid receptor

Mechanism

μ opioid receptor agonists(Mu opioid receptor agonists)

Therapeutic Areas

Nervous System DiseasesOther Diseases

Active Indication

BurnsNeuralgiaPain, Postoperative

Inactive Indication-

Originator Organization

Grand Pharmaceutical (China) Co., Ltd.

Active Organization

Grand Pharmaceutical (China) Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure

Molecular FormulaC16H25N3O

InChIKeyLJLFPZWAVRAQMH-UHFFFAOYSA-N

CAS Registry54152-68-0

A CE electrochemiluminescence (CE–ECL) method for simultaneous determination of lappaconitine hydrobromide (LH) and isopropiram fumarate (IF) has been first established, with a chemically modified platinum electrode by europium (III)‐doped Prussian blue analogue film as a working electrode. The conditions for CE separation and ECL detection are discussed and optimized in detail. It has been proved that 20 mmol/L phosphate buffer (pH 8.5) containing 5% (v/v) ACN and 0.17 mol/L SDS could achieve the most favorable resolution, and the high sensitivity of detection was obtained by maintaining the detection potential at 1.23 V. Under optimized conditions, a baseline separation for the two analytes was achieved within 6 min, and the standard curves were linear in the range of 1.0×10−7 ∼ 5.0 × 10−5 g/mL for LH and 4.0 × 10−8 ∼ 1.0 × 10−5 g/mL for IF with the detection limits (3σ) of 6.6 × 10−8 g/mL for LH and 3.7 × 10−8 g/mL for IF, respectively. The precisions of intra‐ and interday measurements for LH and IF were less than 4.21 and 2.61%, respectively. The applicability of the proposed method was illustrated in the determination of LH and IF in rabbit plasma with recoveries between 95.6 and 103.0%.

100 Deals associated with Isopropiram Fumarate

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R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Burns	CN	Grand Pharmaceutical (China) Co., Ltd.	-
Neuralgia	CN	Grand Pharmaceutical (China) Co., Ltd.	-
Pain, Postoperative	CN	Grand Pharmaceutical (China) Co., Ltd.	-