Last update 14 Feb 2026

LY-4257496

Overview

Basic Info

Drug Type
Therapeutic radiopharmaceuticals
Synonyms
LY-4257496
Target
GRPR
Action
antagonists
Mechanism
GRPR antagonists(Gastrin releasing peptide receptor antagonists)
Therapeutic Areas
NeoplasmsDigestive System DisordersSkin and Musculoskeletal Diseases+ [2]
Active Indication
Colorectal CancerEndometrial Stromal SarcomaER-positive/HER2-negative Breast Cancer+ [4]
Inactive Indication-
Originator Organization
Eli Lilly & Co.Eli Lilly & Co.
Active Organization
Eli Lilly & Co.Eli Lilly & Co.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with LY-4257496
NCT07114601
/ RecruitingPhase 1
A Phase 1a/b Multicenter, Open-Label Trial to Evaluate Safety, Tolerability, and Dosimetry of LY4257496, a GRPR-Targeted Radioligand Therapy, in Adults With GRPR-Positive Advanced Solid Tumors (OMNIRAY)
100 Clinical Results associated with LY-4257496
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100 Translational Medicine associated with LY-4257496
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100 Patents (Medical) associated with LY-4257496
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100 Deals associated with LY-4257496
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Colorectal CancerPhase 1
United States
Eli Lilly & Co.Eli Lilly & Co.
06 Aug 2025
Colorectal CancerPhase 1
Canada
Eli Lilly & Co.Eli Lilly & Co.
06 Aug 2025
Colorectal CancerPhase 1
France
Eli Lilly & Co.Eli Lilly & Co.
06 Aug 2025
Colorectal CancerPhase 1
Germany
Eli Lilly & Co.Eli Lilly & Co.
06 Aug 2025
Colorectal CancerPhase 1
Spain
Eli Lilly & Co.Eli Lilly & Co.
06 Aug 2025
Endometrial Stromal SarcomaPhase 1
United States
Eli Lilly & Co.Eli Lilly & Co.
06 Aug 2025
Endometrial Stromal SarcomaPhase 1
Canada
Eli Lilly & Co.Eli Lilly & Co.
06 Aug 2025
Endometrial Stromal SarcomaPhase 1
France
Eli Lilly & Co.Eli Lilly & Co.
06 Aug 2025
Endometrial Stromal SarcomaPhase 1
Germany
Eli Lilly & Co.Eli Lilly & Co.
06 Aug 2025
Endometrial Stromal SarcomaPhase 1
Spain
Eli Lilly & Co.Eli Lilly & Co.
06 Aug 2025
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Clinical Result

Indication
Phase
Evaluation
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Phase
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Deal

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Clinical Trial

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Approval

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Regulation

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