Mols. of N-(2-hydroxyphenyl)-N'-phenethylsuccinamide (phensuccinal), C₁₈H₂₀N₂O₃, adopt a rod-like shape, probably influenced by N-H···O and O-H···O intermol. H bonds, which also determine the formation of polymeric chains along the glide direction.Crystallog. data are given.

01 Jan 2001·Bulletin of Experimental Biology and MedicineQ4 · MEDICINE

Effect of phensuccinal on pancreatic beta-cells in rats with neonatally induced streptozotocin diabetes mellitus.

Q4 · MEDICINE

Article

Author: A. I. Gladkikh ; O. V. Ivanova ; N. I. Gorbenko ; V. V. Poltorak

The effect of phensuccinal, a low-toxic succinic acid derivative, on the function of pancreatic beta-cells in the evolution of absolute insulin insufficiency was studied in rats with neonatally induced streptozotocin diabetes mellitus. Phensuccinal (25 mg/kg body weight) prevented disorders in the secretory response of beta-cells to glucose load at all stages of the study (2, 5, and 14 days after diabetes induction). This effect was realized via stimulation of the regenerative processes in the insulin-producing system of the pancreas and activation of the antioxidant system in diabetic animals.

01 Jul 2000·Bulletin of Experimental Biology and MedicineQ4 · MEDICINE

Effect of fensuccinal on experimental insulin resistance

Q4 · MEDICINE

Article

Author: A. I. Gladkikh ; O. V. Ivanova ; N. I. Gorbenko ; V. V. Poltorak

The effects of new antioxidant fensuccinal on dexamethasone-induced insulin resistance in rats were studied. Oral administration of fensuccinal in a dose of 25 mg/kg for 2 weeks prevented basal hyperinsulinemia and insulin insensitivity of peripheral tissues. Fensuccinal also attenuated oxidative stress by decreasing the concentrations of primary and secondary lipid peroxidation products in liver homogenates. The ability of fensuccinal to prevent dexamethasone-induced insulin resistance is probably due to its antioxidant properties.

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Indication	Highest Phase	Country/Location	Organization	Date
Diabetes Mellitus	Preclinical	-	Ukrainian Scientific Research Institute	-
Diabetes Mellitus	Preclinical	Ukraine	-	-

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