Dopamine intranasal(MetP Pharma AG)

Combination therapy is a promising strategy for lung adenocarcinoma (LUAD), due to the advantages of overcoming drug resistance, side effects, and tumor heterogeneity. Herein, we report a novel dual-targeting bimetallic nanozyme (MH-iRGD) consisting of nanosized manganese ferrite (MF) after encapsulating with dopamine and methacrylic anhydride to modify hyaluronic acid, followed by integrin receptor targeting peptide (HS-PEG3400-iRGD) modification for LUAD targeted therapy. Our study confirmed that MH-iRGD combined with near-infrared irradiation (NIR) possessed dramatic photothermal effects and reactive oxygen species (ROS) production and GSH depletion abilities. Importantly, MH-iRGD possessed dual-targeting capacities for LUAD cells overexpressed CD44 and αV-integrin receptors owing to hyaluronic acid coating and iRGD modification. Inhibitors of CD44 and integrins could impair the uptake of MH-iRGD in LUAD cells. Moreover, MH-iRGD + NIR displayed excellent anti-LUAD effects as a result of the production of intracellular ROS, consumption of glutathione (GSH) and mitochondrial dysfunction. Mechanistically, NIR robustly strengthened MH-iRGD-induced ferroptosis and apoptosis by down-regulating SLC7A11, GPX4, Bcl-2 levels while up-regulating Bax level. Specifically, ferroptosis and apoptosis were increased while the LUAD progression was inhibited after intravenous injection of MH-iRGD + NIR in xenograft mouse models. Taken together, our results indicate that MH-iRGD + NIR serves as a promising targeted therapy for LUAD, which broadens the applications of highly active dual-targeting bimetallic nanozymes.

A new type of electrochem. sensor, a ferrite-polyaniline nanocomposite to simultaneously detect resorcinol (Res) and dopamine (DA) was developed.Glassy carbon electrode modification involved the integration of Fe3O4-PANI.Structural and surface analyses were performed using SEM (SEM), X-ray Diffraction (XRD), UV Visible (UV-Vis) Spectroscopy, and Fourier Transformation IR (FTIR) techniques.The sensor (GCE@Fe3O4-PANI) exhibited a wide linear range under optimal pH conditions (7.0-7.4), (0.002μM-1500 μM) for both DA and Res, with low detection limits of 2.84 nMand 1.403 nM, resp.Sensitivity was recorded at 1.10 x 10-4 A μM-1cm^-2 making it suitable for clin. diagnostics and environmental applications.The suitability of the sensor was confirmed by chronoamperometry, differential pulse voltammetry (DPV), cyclic voltammetry (CV), and electrochem. impedance spectroscopy (EIS).This demonstrates the substantial potential of Fe3O4-PANI nanocomposite for the simultaneous and selective identification of DA and Res.