Last update 21 Nov 2024

Dapivirine/Levonorgestrel

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms-
Target
PR x RT
Mechanism
PR antagonists(Progesterone receptor antagonists), RT inhibitors(Reverse transcriptase inhibitors)
Therapeutic Areas
Other DiseasesImmune System DiseasesInfectious Diseases+ [1]
Active Indication
HemorrhageHIV Infections
Inactive Indication-
Originator Organization
International Partnership for MicrobicidesInternational Partnership for Microbicides
Active Organization
International Partnership for MicrobicidesInternational Partnership for MicrobicidesINC Research Holdings, Inc.National Institutes of HealthNational Institutes of Health
Inactive Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC21H28O2
InChIKeyWWYNJERNGUHSAO-XUDSTZEESA-N
CAS Registry797-63-7
View All Structures (2)

Related

2
Clinical Trials associated with Dapivirine/Levonorgestrel
NCT05041699 / CompletedPhase 1/2
A Randomized, Double-Blind, Phase 1b Study in Healthy HIV-Negative Women to Evaluate the Pharmacokinetics, Safety, and Bleeding Patterns Associated With 90-Day Use of Core-Sheath Vaginal Rings Releasing Dapivirine and Levonorgestrel
NCT03467347 / CompletedPhase 1
A Randomized, Phase 1, Open-Label Study in Healthy HIV-Negative Women to Evaluate the Pharmacokinetics, Safety and Bleeding Patterns Associated With 90-Day Use of Matrix Vaginal Rings Containing 200 mg Dapivirine and 320 mg Levonorgestrel
100 Clinical Results associated with Dapivirine/Levonorgestrel
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100 Translational Medicine associated with Dapivirine/Levonorgestrel
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100 Patents (Medical) associated with Dapivirine/Levonorgestrel
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100 Deals associated with Dapivirine/Levonorgestrel
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HemorrhagePhase 2
US
INC Research Holdings, Inc.
20 Jun 2022
HIV InfectionsPhase 1-
International Partnership for MicrobicidesInternational Partnership for Microbicides
-
HIV InfectionsPhase 1-
National Institutes of HealthNational Institutes of Health
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
The Ring Study and DREAM (Pubmed)
Phase 3
HIV Infections
-
qfilqqshst(hegkqesugj) = ssrvncbfhz wwafkowdld (bcyuzkjadu )
-
08 Nov 2022
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Approval

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Regulation

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