Last update 27 Feb 2026

Amiloride Hydrochloride/Spironolactone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Amiloride/spironolactone, Spironolactone/Amiloride, Spironolactone/Amiloride-Hydrochloride
+ [1]
Target
ENaCα x MR
Action
inhibitors, antagonists
Mechanism
ENaCα inhibitors(sodium channel epithelial 1 subunit alpha inhibitors), MR antagonists(Mineralocorticoid receptor antagonists)
Therapeutic Areas
Cardiovascular Diseases
Active Indication-
Inactive Indication
Hypertension
Originator Organization
The University of AlabamaThe University of Alabama
Active Organization-
Inactive Organization
Hemodynamic Therapeutics, Inc.
The University of AlabamaThe University of Alabama
License Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC24H32O4S
InChIKeyLXMSZDCAJNLERA-ZHYRCANASA-N
CAS Registry52-01-7
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Related

100 Clinical Results associated with Amiloride Hydrochloride/Spironolactone
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100 Translational Medicine associated with Amiloride Hydrochloride/Spironolactone
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100 Patents (Medical) associated with Amiloride Hydrochloride/Spironolactone
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100 Deals associated with Amiloride Hydrochloride/Spironolactone
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
HypertensionPhase 2
United States
--
HypertensionPhase 2-
Hemodynamic Therapeutics, Inc.
-
HypertensionPhase 2-
The University of AlabamaThe University of Alabama
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Deal

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Clinical Trial

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Approval

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Regulation

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