Delving into the Latest Updates on Codeine Phosphate/Naproxen with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target

COXs x Opioid receptors

Action

inhibitors, agonists

Mechanism

COX inhibitors(Cyclooxygenases inhibitors), Opioid receptors agonists(Opioid receptors agonists)

Therapeutic Areas

Nervous System DiseasesOther Diseases

Active Indication

Pain

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC14H14O3

InChIKeyCMWTZPSULFXXJA-VIFPVBQESA-N

CAS Registry22204-53-1

View All Structures (2)

Acute dental pain is one of the most challenging conditions to treat and manage in dental practice. The aim of this study was to compare the efficacy of naproxen sodium + codeine phosphate (550/30 mg) and dexketoprofen trometamol + paracetamol (25/300 mg) in the treatment of acute dental pain in individuals with acute pericoronitis caused by impacted wisdom teeth.

Start Date10 Jan 2023

Sponsor / Collaborator

Yüzüncü Yıl University

NCT02255955

/ Unknown statusPhase 4IIT

The Effect of Naproxen Sodium + Codeine, and Paracetamol+ Codeine on Postoperative Laminectomy Pain

Compare the analgesic effects of naproxen sodium codeine, paracetamol codeine and placebo on postoperative pain and tramadol (Contramal) consumption during the first 24 hour after a lumbar disk surgery.

Start Date01 Oct 2014

Sponsor / Collaborator-

NCT02501564

/ CompletedPhase 4IIT

Randomized, Double-blind and Placebo-controlled Evaluation of Efficacy and Safety of Naproxen Sodium and Codeine Phosphate Combination in Osteoarthritis

Osteoarthritis (OA) pain treatment has limitations in terms of serious adverse effects and low efficacy. The investigators aimed to evaluate efficacy and safety of naproxen sodium/codeine phosphate combination in these patients.

Start Date01 May 2013

Sponsor / Collaborator