[Translation] A Phase I clinical study to evaluate the safety, tolerability, pharmacokinetic characteristics and food effects of a single dose of JKN2306 tablets in healthy subjects
评价健康受试者单次口服 JKN2306 片的安全性和耐受性。
次要目的:评 价 健 康 受 试 者 单 次 口 服 JKN2306 片 的 药 代 动 力 学(Pharmacokinetics,PK)特征;评价高脂饮食对健康受试者单次口服JKN2306片后PK特征的影响。
探索性目的:探索性评估健康受试者单次口服 JKN2306 片后的 C-QTc 关系;探索性评估健康受试者单次口服 JKN2306 片后血液中的代谢产物。
[Translation] To evaluate the safety and tolerability of a single oral administration of JKN2306 tablets in healthy subjects.
Secondary objectives: To evaluate the pharmacokinetic (PK) characteristics of a single oral administration of JKN2306 tablets in healthy subjects; to evaluate the effect of a high-fat diet on the PK characteristics of a single oral administration of JKN2306 tablets in healthy subjects.
Exploratory objectives: To explore the C-QTc relationship after a single oral administration of JKN2306 tablets in healthy subjects; to explore the metabolites in the blood after a single oral administration of JKN2306 tablets in healthy subjects.