Last update 24 Mar 2025

LY-178002

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
LY178002, LY-178002
Target
5-LOX x PLA2 x PLA2G2A
Action
inhibitors
Mechanism
5-LOX inhibitors(Arachidonate 5-lipoxygenase inhibitors), PLA2 inhibitors(Phospholipases A2 inhibitors), PLA2G2A inhibitors(Phospholipase A2 group IIA inhibitors)
Therapeutic Areas
Skin and Musculoskeletal DiseasesNervous System DiseasesCardiovascular Diseases+ [1]
Active Indication-
Inactive Indication
ArthritisInflammationischemic brain injury
Originator Organization
Eli Lilly & Co.Eli Lilly & Co.
Active Organization-
Inactive Organization
Lilly Research LaboratoriesEli Lilly & Co.Eli Lilly & Co.
Drug Highest PhasePendingPreclinical
First Approval Date-
Regulation-

Structure/Sequence

Molecular FormulaC18H25NO2S
InChIKeyBUDGLLLMROWLOB-UHFFFAOYSA-N
CAS Registry107889-32-7

Related

100 Clinical Results associated with LY-178002
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100 Translational Medicine associated with LY-178002
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100 Patents (Medical) associated with LY-178002
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8
Literatures (Medical) associated with LY-178002
01 Jul 1997Tetrahedron, asymmetry
Substrate specificity of the kinetic resolution of sulfides by enantioselective sulfoxide formation
01 Nov 1994Annals of the New York Academy of SciencesQ2 · CROSS-FIELD
Neuroprotection by Antioxidants in Models of Global and Focal Ischemia
Q2 · CROSS-FIELD
01 Sep 1994TETRAHEDRON LETTERS
Synthesis of 4-thiazolidinones from rhodanines by thiocarbonyl removal
100 Deals associated with LY-178002
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
ArthritisPreclinical
United States
Lilly Research Laboratories
01 Jun 1989
InflammationDiscovery
United States
Eli Lilly & Co.Eli Lilly & Co.
08 Aug 1986
ischemic brain injuryDiscovery
United States
Eli Lilly & Co.Eli Lilly & Co.
08 Aug 1986
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Approval

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Regulation

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